2015
DOI: 10.1159/000438884
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Nutritional and Pubertal Disorders

Abstract: Caloric-protein malnutrition can slow growth and cause pubertal delay. This chapter focuses on endocrine abnormalities and pubertal alterations in patients with eating disorders, childhood obesity, the female athlete triad and children cancer survivors. Patients with anorexia nervosa (AN) exhibit multiple endocrine abnormalities, including isolated hypogonadotropic hypogonadism. The delay in pubertal development and reduction in growth seen in AN patients may be a direct result of malnutrition. Appropriate psy… Show more

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Cited by 26 publications
(26 citation statements)
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“…The timing of puberty is fitted to metabolic and nutritional conditions of the organism. The translational relevance of such metabolic influence on puberty onset is epitomized by the dramatic impact of conditions of metabolic stress, including malnutrition, on the age of puberty in humans (12,13). AMPK is a fundamental cellular energy gauge, which acting on discrete neuronal populations at different hypothalamic nuclei, plays an essential role in whole-body metabolic homeostasis, and its coordination with multiple vital functions and hormonal pathways (17).…”
Section: Discussionmentioning
confidence: 99%
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“…The timing of puberty is fitted to metabolic and nutritional conditions of the organism. The translational relevance of such metabolic influence on puberty onset is epitomized by the dramatic impact of conditions of metabolic stress, including malnutrition, on the age of puberty in humans (12,13). AMPK is a fundamental cellular energy gauge, which acting on discrete neuronal populations at different hypothalamic nuclei, plays an essential role in whole-body metabolic homeostasis, and its coordination with multiple vital functions and hormonal pathways (17).…”
Section: Discussionmentioning
confidence: 99%
“…One of the most important determinants of puberty onset is the nutritional and metabolic state (10,11). Conditions of metabolic stress, from cachexia to early-onset obesity, are linked to perturbed pubertal timing (12,13). Indeed, while the higher frequency of child obesity has been related to the trends of earlier puberty (5,6), conditions of persistent energy deficit, ranging from eating disorders to strenuous exercise, are known to severely delay pubertal maturation (13).…”
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confidence: 99%
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“…Немаловажен и тот факт, что заболевания ВНЧС развиваются до-вольно рано, зачастую в детском возрасте [8,10]. Нужно учитывать, что к нарушениям функции ВНЧС может приводить само ортодонтическое лечение, так как связано с разобщением зубных рядов, изменением привычной окклюзии, переме-щением нижней челюсти [2,3,7].…”
Section: стоматологіяunclassified
“…Данный факт является подтверждением первично-сти функциональной патологии и перехода ее че-рез изменение качественного состава кости (в дан-ном случае ее плотности) к последующим морфо-анатомическим изменениям головок ВНЧС, что подтверждается данными других авторов [8,9,10].…”
Section: стоматологіяunclassified