Nutritional and pharmacological importance of stinging nettle (Urtica dioica L.): A review

Bhusal, Khuma Kumari; Magar, Saraddha Khasu; Thapa, Ronika; Lamsal, Ashish; Bhandari, Sagar; Maharjan, R; Shrestha, Sami; Shrestha, Jiban

doi:10.1016/j.heliyon.2022.e09717

Cited by 76 publications

(70 citation statements)

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“…The various phytochemicals in the UD, MC, and MK extracts that are responsible for their antioxidant and protective potential have been well identified. UD has been extensively studied and has shown prominent results in the treatment of prostate enlargement [ 13 ], preventing colon carcinogenesis in rats [ 14 ], and providing a protective effect against hyperglycemia [ 15 ], hypertension [ 16 ], and hypercholesterolemia [ 17 ]. Numerous studies have shown that MC counteracts diabetes by controlling GLP-1, which is essential for promoting insulin gene transcription [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…The phytochemicals of these three herbs, such as quercetin, polyphenols, alkaloids, reducing sugars, and vitamins, are known for their protective effects. UD has been extensively studied and has shown promising results in the treatment of prostate enlargement [ 13 ], colon carcinogenesis in rats [ 14 ], and protecting against hyperglycemia [ 15 ], hypertension, [ 16 ] and hypercholesterolemia [ 17 ]. Several studies have demonstrated the beneficial effects of MC against diabetes by regulating GLP-1, which is crucial in stimulating insulin gene transcription [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Ethnopharmacological Effects of Urtica dioica, Matricaria chamomilla, and Murraya koenigii on Rotenone-Exposed D. melanogaster: An Attenuation of Cellular, Biochemical, and Organismal Markers

et al. 2022

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Natural antioxidants derived from plants have been proven to have significant inhibitory effects on the free radicals of living organisms during actively metabolization. Excessive production of free radicals increases the risk of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and motor sclerosis. This study aimed to compare the ethnopharmacological effects of Urtica dioica (UD), Matricaria chamomilla (MC), and Murraya koenigii (MK) on the amelioration of rotenone-induced toxicity in wild-type Drosophila melanogaster (Oregon R+) at biochemical, cellular, and behavioral levels. Phytoextracts were prepared from all three plants, i.e., UD, MC, and MK (aqueous and ethanolic fractions), and their bioactive compounds were evaluated using in vitro biochemical parameters (DPPH, ABTS, TPC, and TFC), UV-Vis, followed by FT-IR and HPLC. Third instar larvae and freshly eclosed flies were treated with 500 µM rotenone alone or in combination with UD, MC, and MK for 24 to 120 h. Following exposure, cytotoxicity (dye exclusion test), biochemical (protein estimation and acetylcholinesterase inhibition assays), and behavioral assays (climbing and jumping assays) were performed. Among all three plant extracts, MK exhibited the highest antioxidant properties due to the highest TPC, TFC, DPPH, and ABTS, followed by UD, then MC. The overall trend was MK > UD > MC. In this context, ethnopharmacological properties mimic the same effect in Drosophila, exhibiting significantly (p < 0.05) reduced cytotoxicity (trypan blue), improved biochemical parameters (proteotoxicity and AChE activity), and better behavioral parameters in the organisms cotreated with phyto extracts compared with rotenone. Conclusively, UV-Vis, FTIR, and HPLC analyses differentiated the plant extracts. The findings of this research may be beneficial in the use of select herbs as viable sources of phyto-ingredients that could be of interest in nutraceutical development and various clinical applications.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ethnopharmacological Effects of Urtica dioica, Matricaria chamomilla, and Murraya koenigii on Rotenone-Exposed D. melanogaster: An Attenuation of Cellular, Biochemical, and Organismal Markers

et al. 2022

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“…For the contemporary study, three herbs from the Northern Himalayan region of India were selected. These medicinal herbs were shortlisted, based on their pharmacological activities, affirmation of their persistent usage, and native accessibility [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Appraisal of the Antioxidant Activity, Polyphenolic Content, and Characterization of Selected Himalayan Herbs: Anti-Proliferative Potential in HepG2 Cells

Yousuf

Shabir²,

Kauts³

et al. 2022

Molecules

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Natural antioxidants derived from plants have played a vital role in preventing a wide range of human chronic conditions and provide novel bioactive leads for investigators in pharmacotherapy discovery. This work was designed to examine the ethnopharmacological role of Urtica dioica (UD), Capsella bursa-pastoris (CBP), and Inula racemosa (IR). The total phenolic and flavonoid contents (TPC and TFC) were illustrated through colorimetric assays, while the antioxidant activity was investigated through DPPH and ABTS assays. The evaluation of phytochemicals by FT-IR of UD and CBP revealed high contents of aliphatic amines, while IR showed a major peak for ketones. The antioxidant activity, TPC and TFC were highest in the ethanol extract of UD, followed by CBP, and IR showed the lowest activity. All of the extracts revealed significant antioxidant capacities along a dosage gradient. Through a HPLC analysis at a wavelength of 280 nm, UD leaves demonstrated an intense peak of quercetin, and the peak for rutin was less intense. CBP (whole plant), instead, demonstrated a major yield of rutin, and a peak for quercetin was not observed in CBP. IR (rhizomes) showed both quercetin and rutin. All of the extracts were significantly cytotoxic to HepG2 cells after 48 h with the trend IR > UD > CBP. The outcomes of this study may be effective in the selection of specific plants as realistic sources of the bioactive components that might be useful in the nutraceutical progression and other biomedical efficacies.

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“…Considering the huge medicinal potential of UD, several reviews have attempted to catalog the phytochemicals and different pharmacological properties of UD [ 3 , 18 , 33 , 34 , 35 ]. These reviews compiled the phytochemical, therapeutics, and all pharmacological properties of UD [ 35 ], or focused on some disease such as cancer, diabetes and cardiovascular diseases [ 18 , 19 ] reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

“…These reviews compiled the phytochemical, therapeutics, and all pharmacological properties of UD [ 35 ], or focused on some disease such as cancer, diabetes and cardiovascular diseases [ 18 , 19 ] reported in the literature. Some reviews also discussed the nutritional and other benefits of UD [ 33 , 35 ]. The antioxidant properties of UD were observed in a huge number of studies against various diseases.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity of Urtica dioica: An Important Property Contributing to Multiple Biological Activities

Jaiswal

Lee

2022

Antioxidants

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Urtica dioica (UD) is a multi-functional plant known to be used as both food and medicine from ancient times. The plant has the potential to be used as a fertilizer and for biological pest control. It is also used in textile and related industries for its quality fibers. In the recent past, the plant has received great attention for its numerous important biological activities and food applications. The antioxidant activity of UD is the crucial factor supporting its important biological activities, such as anticancer, antidiabetic and anti-inflammatory properties. The antioxidant activity of UD is also found to be protective in different organs, including the brain, liver, lungs, kidney, ovary, and uterus, and may also be protective against diseases associated with these organs. Few clinical studies have endorsed the antioxidant potential of UD in patients. The current work is an attempt to comprehensively compile and discuss the antioxidant activity of UD from in vitro, in vivo and human studies. The insights of the current study would be helpful in getting a panoramic view of the antioxidant potential of UD, and provide direction for optimizing and developing it for therapeutic applications against important diseases and conditions in the near future.

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Nutritional and pharmacological importance of stinging nettle (Urtica dioica L.): A review

Cited by 76 publications

References 65 publications

Ethnopharmacological Effects of Urtica dioica, Matricaria chamomilla, and Murraya koenigii on Rotenone-Exposed D. melanogaster: An Attenuation of Cellular, Biochemical, and Organismal Markers

Ethnopharmacological Effects of Urtica dioica, Matricaria chamomilla, and Murraya koenigii on Rotenone-Exposed D. melanogaster: An Attenuation of Cellular, Biochemical, and Organismal Markers

Appraisal of the Antioxidant Activity, Polyphenolic Content, and Characterization of Selected Himalayan Herbs: Anti-Proliferative Potential in HepG2 Cells

Antioxidant Activity of Urtica dioica: An Important Property Contributing to Multiple Biological Activities

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