Nutritional and immunologic evaluation of patients with gastric cancer before and after surgery

Rey-Ferro, Mario; Castaño, Rodrigo; Orozco, O; Serna, Angela; Moreno, Ana

doi:10.1016/s0899-9007(97)00269-4

Cited by 107 publications

(61 citation statements)

References 13 publications

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“…Gavazzi et al 21 found weight loss over 5% in the previous three months in 35% of patients recently diagnosed with gastric carcinoma. Rey-Ferro et al 22 found an average of 10% weight loss, and in those who died postoperatively, weight loss had been significantly higher than in those who survived (p=0.06). These results were also confirmed in the study by Shim et al 6 , in which preoperative weight loss (p=0.008) and gastric cancer (p<0.001)…”

Section: Discussionmentioning

confidence: 93%

“…In their study, Rey-Ferro et al 22 argue that hypoalbuminemia and weight loss have a positive predictive value for mortality in patients with gastric cancer. In a multicenter US Gastric Cancer Collaborative study involving 775 patients undergoing gastrectomy, Ejaz et al 31 observed that BMI < 18.5kg/m 2 and low levels of albumin were related to a significant decrease in overall survival after gastrectomy.…”

Section: Discussionmentioning

confidence: 95%

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Nutritional assessment methods as predictors of postoperative mortality in gastric cancer patients submitted to gastrectomy

Poziomyck

Cavazzola

Coelho

et al. 2017

Rev. Col. Bras. Cir.

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Objectives: to determine the nutritional evaluation method that best predicts mortality in 90 days of patients submitted to gastrectomy for gastric cancer. Methods: we conducted a prospective study with 44 patients with gastric cancer, stages II to IIIa, of whom nine were submitted to partial gastrectomy, 34 to total gastrectomy, and one to esophago-gastrectomy. All patients were nutritionally evaluated through the same protocol, up to 72h after hospital admission. The parameters used were Patient-Generated Subjective Global Assessment (PGSGA), classical anthropometry, current weight and height, percentage of weight loss (%WL) and body mass index (BMI). We also measured the thickness of the thumb adductor muscle (TAM) in both hands, dominant hand (TAMD) and non-dominant hand (TAMND), as well as the calculated the prognostic nutritional index (PNI). The laboratory profile included serum levels of albumin, erythrocytes, hemoglobin, hematocrit, leukocytes, and total lymphocytes count (TLC). Results: of the 44 patients studied, 29 (66%) were malnourished by the subjective method, 15 being grade A, 18 grade B and 11 grade C. Cases with PGSGA grade B and TAMD 10.2±2.9 mm were significantly associated with higher mortality. The ROC curves (95% confidence interval) of both PGSGA and TAMD thickness reliably predicted mortality at 30 and 90 days. No laboratory method allowed predicting mortality at 90 days. Conclusion: PGSGA and the TAMD thickness can be used as preoperative parameters for risk of death in patients undergoing gastrectomy for gastric cancer.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 95%

Nutritional assessment methods as predictors of postoperative mortality in gastric cancer patients submitted to gastrectomy

Poziomyck

Cavazzola

Coelho

et al. 2017

Rev. Col. Bras. Cir.

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“…Weight loss has been considered among the potential prognostic factors for gastric cancer by at least 13 studies so far, and in 10 of these it resulted significantly and independently related to the fatal outcome [19,39,40,[42][43][44][45][46][47][48][49][50][51] . It is not possible to calculate life expectancy in gastric cancer patients presenting with weight loss.…”

Section: Specific Symptoms and Outcome Of Gastric Cancermentioning

confidence: 99%

Role of symptoms in diagnosis and outcome of gastric cancer

Maconi¹,

Manes²,

Porro³

2008

WJG

184

105

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Gastric cancer is one of the most common cancers and the second most common cause of cancer deaths w o r l d w i d e . A p a r t f r o m J a p a n , w h e r e s c r e e n i n g programmes have resulted in early diagnosis in asymptomatic patients, in most countries the diagnosis of gastric cancers is invariably made on account on dyspeptic and alarm symptoms, which may also be of prognostic significance when reported by the patient at diagnosis. However, their use as selection criteria for endoscopy seems to be inconsistent since alarm symptoms are not sufficiently sensitive to detect malignancies. In fact, the overall prevalence of these symptoms in dyspeptic patients is high, while the prevalence of gastro-intestinal cancer is very low. Moreover, symptoms of early stage cancer may be indistinguishable from those of benign dyspepsia, while the presence of alarm symptoms may imply an advanced and often inoperable disease. The features of dyspeptic and alarm symptoms may reflect the pathology of the tumour and be of prognostic value in suggesting site, stage and aggressiveness of cancer. Alarm symptoms in gastric cancer are independently related to survival and an increased number, as well as specific alarm symptoms, are closely correlated to the risk of death. Dysphagia, weight loss and a palpable abdominal mass appear to be major independent prognostic factors in gastric cancer, while gastro-intestinal bleeding, vomiting and also duration of symptoms, do not seem to have a relevant prognostic impact on survival in gastric cancer.

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“…It was found that the expression level of CD3 + , CD4 + /CD8 + and NK + cells in preoperative patients with colorectal cancer was positively correlated with the prognosis (Wang et al, 1999). The studies indicated that CD4 + /CD8 + ratio was an objective indicator to evaluate the prognosis of GC patients, a lower ratio meaning a higher risk of local recurrence and distant metastasis, resulting poor prognosis (Rey-Ferro et al, 1997). A few studies have shown that CD4 + , CD8 + expression levels in patients with esophageal cancer was significantly positively correlated with survival (Cho et al, 2003;Nozoe et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Elevated Circulating CD19⁺Lymphocytes Predict Survival Advantage in Patients with Gastric Cancer

Qian¹,

Yu²,

Ling³

2012

Asian Pacific Journal of Cancer Prevention

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Nutritional and immunologic evaluation of patients with gastric cancer before and after surgery

Cited by 107 publications

References 13 publications

Nutritional assessment methods as predictors of postoperative mortality in gastric cancer patients submitted to gastrectomy

Nutritional assessment methods as predictors of postoperative mortality in gastric cancer patients submitted to gastrectomy

Role of symptoms in diagnosis and outcome of gastric cancer

Elevated Circulating CD19⁺Lymphocytes Predict Survival Advantage in Patients with Gastric Cancer

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Nutritional and immunologic evaluation of patients with gastric cancer before and after surgery

Cited by 107 publications

References 13 publications

Nutritional assessment methods as predictors of postoperative mortality in gastric cancer patients submitted to gastrectomy

Nutritional assessment methods as predictors of postoperative mortality in gastric cancer patients submitted to gastrectomy

Role of symptoms in diagnosis and outcome of gastric cancer

Elevated Circulating CD19+Lymphocytes Predict Survival Advantage in Patients with Gastric Cancer

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Product

Resources

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Elevated Circulating CD19⁺Lymphocytes Predict Survival Advantage in Patients with Gastric Cancer