Nutrition

Smith, Arthur H.

doi:10.1146/annurev.bi.02.070133.001503

Annu. Rev. Biochem.

1933

DOI: 10.1146/annurev.bi.02.070133.001503

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Nutrition

Arthur H. Smith¹

Abstract: Annu. Rev. Biochem. 1933.2:299-316. Downloaded from www.annualreviews.org Access provided by Michigan State University Library on 02/03/15. For personal use only. Quick links to online content Further ANNUAL REVIEWS Annu. Rev. Biochem. 1933.2:299-316. Downloaded from www.annualreviews.org Access provided by Michigan State University Library on 02/03/15. For personal use only.

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Long‐term adaptive response to dietary protein of hexose monophosphate shunt dehydrogenases in rat kidney tubules

Peragón

Aranda

Garcı́a-Salguero

et al. 1990

Cell Biochemistry & Function

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We have studied the effects of several different macronutrients on the kinetic behaviour of rat renal glucose 6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH). Rats were meal-fed with high-carbohydrate/low-protein, high-protein/low-carbohydrate and high-fat diets. High-protein increased renal G6PDH and 6PDGH activities by 66 per cent and 70 per cent respectively, without significantly changing the Km values of either and each Hexose monophosphate dehydrogenase activity increased steadily, reaching a significant difference on day 4. A rise in carbohydrate or fat in the diets, produced no significant change in either the activity or the kinetic parameters, Vmax and Km of the two dehydrogenases. In addition, the administration of a high-protein diet for 8 days significantly increased both the pentose phosphate pathway flux (92.6 per cent) and the kidney weigth (35 per cent), whereas no significant changes in these parameters were found when the animals were treated with the other diets. Our results suggest that an increase in the levels of dietary protein induces a rise in the intracellular levels of these enzymes. The possible role of this metabolic pathway in the kidneys under these nutritional conditions is also discussed.

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Long‐term adaptive response to dietary protein of hexose monophosphate shunt dehydrogenases in rat kidney tubules

Peragón

Aranda

Garcı́a-Salguero

et al. 1990

Cell Biochemistry & Function

View full text Add to dashboard Cite

show abstract

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Nutrition

Cited by 1 publication

References 16 publications

Long‐term adaptive response to dietary protein of hexose monophosphate shunt dehydrogenases in rat kidney tubules

Long‐term adaptive response to dietary protein of hexose monophosphate shunt dehydrogenases in rat kidney tubules

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