Nutrition Therapy Regulates Caffeine Metabolism with Relevance to NAFLD and Induction of Type 3 Diabetes

Martins, Ian James

doi:10.24966/dmd-201x/100019

Cited by 39 publications

(39 citation statements)

References 111 publications

(131 reference statements)

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“…The calculated fat content in man has now been determined by author's calculations to be approximately 20-30 g/day [13] and differs from other international researchers [111]. In several laboratories, cellular cholesterol levels are associated with increased amyloid beta formation in the brain and periphery [37], and Sirt 1 downregulation is associated with defective caffeine and cholesterol metabolism (Figure 4) with relevance to hepatic amyloid beta clearance and induction of NAFLD [112]. Increased plasma caffeine levels displace amyloid beta and fatty acids from albumin by competition for albumin binding sites [113] with relevance to amyloid beta aggregation [114].…”

Section: Defective Adipose Tissue-liver Crosstalk In the Induction Ofmentioning

confidence: 99%

“…LPS interferes with the SCN and adipose tissue-liver crosstalk [10,85,135,136] and delays hepatic drug metabolism [165,166] with premature brain aging and chronic disease progression (Figure 6). LPS induces changes in plasma albumin contents [112] in individuals in the developing world with relevance to interference with caffeine and its therapeutic properties with relevance to SCN regulation of adipose tissue-liver crosstalk. In recent studies, caffeine intake and glucose dyshomeostasis that supersede insulin therapy [142,143] has raised concerns with relevance to glucose/amyloid beta-induced mitochondrial apoptosis and the induction of NAFLD.…”

Section: Nutritional Diets Maintain Brain and Adipose Tissue-liver Crmentioning

confidence: 99%

“…Sirt 1 targets transcription factors such as peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1-alpha) and p53 to adapt gene expression to mitochondrial function by deacetylation of PGC1-alpha and p53 transcription factors [10], which are important to mitochondrial DNA homeostasis and mitochondrial biogenesis [122][123][124][125][126]. Inhibitors and activators of Sirt 1 [112] have been identified that may override caffeine and its role as a Sirt 1 modulator [27,95,112]. Inhibitors include alcohol, sirtinol, suramin and activators include leucine, pyruvic acid, and alpha-lipoic acid.…”

Section: Defective Adipose Tissue-liver Crosstalk In the Induction Ofmentioning

confidence: 99%

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Caffeine with Links to NAFLD and Accelerated Brain Aging

Martins¹

2018

Non-Alcoholic Fatty Liver Disease - Molecular Bases, Prevention and Treatment

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Nutritional diets are essential to prevent nonalcoholic fatty liver disease (NAFLD) in the global obesity and diabetes epidemic. The ingestion of palmitic acid-rich diets induces NAFLD in animal and human studies. The beneficial properties of olive oil (oleic acid) may be superseded by ingestion of palmitic acid-rich diets. Hepatic caffeine metabolism is regulated by palmitic and oleic acid with effects of these fats on amyloid beta metabolism. Healthy fats such as olive oil may facilitate rapid amyloid beta clearance in the periphery to maintain drug therapy in diabetes and various neurological diseases. Repression of the anti-aging gene sirtuin 1 (Sirt 1) prevents the beneficial properties of olive oil. Brain disorders induce NAFLD and supersede caffeine's therapeutic effects in the prevention of NAFLD. Delayed hepatic caffeine metabolism in NAFLD and increased caffeine transport to the brain with aging-induced mitophagy in neurons with induction of type 3 diabetes and neurodegenerative disease.

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Section: Defective Adipose Tissue-liver Crosstalk In the Induction Ofmentioning

confidence: 99%

Section: Nutritional Diets Maintain Brain and Adipose Tissue-liver Crmentioning

confidence: 99%

Section: Defective Adipose Tissue-liver Crosstalk In the Induction Ofmentioning

confidence: 99%

See 1 more Smart Citation

Caffeine with Links to NAFLD and Accelerated Brain Aging

Martins¹

2018

Non-Alcoholic Fatty Liver Disease - Molecular Bases, Prevention and Treatment

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“…Caffeine and its metabolism is critical to cardiovascular disease [50][51][52] with Indian spice intake (mg/day) now important with relevance to interference with caffeine's therapeutic properties in man and various species. Delayed caffeine clearance leads to interference with caffeine's bene icial effect on adipogenesis with increased transport to the brain relevant to mitochondrial induced apoptosis and the induction of Type 3 diabetes [26][27][28].…”

Section: Editorialmentioning

confidence: 99%

“…Sirt 1 is the heat shock gene [22,23] with its repression involved with dysregulation of heat shock protein 70 (HSP70), natural killer cell activation and mitophagy [24]. Defective adipose tissue-liver interaction has been treated with caffeine to prevent mitophagy [25,26] linked to adipocyte dysfunction and reversal of NAFLD [27]. Nutrition therapy that allows co-ordination between the brain, adipose tissue and liver activates the apelinergic-Sirt 1 interaction essential for hepatic caffeine metabolism and caffeine's critical role as modulation of Sirt 1 in the brain [28] important to the prevention of obesity.…”

Section: Editorialmentioning

confidence: 99%

Indian spices and Caffeine treatment for Obesity and Cardiovascular disease

Martins¹

2017

Ann Clin Endocrinol Metabol

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The Effect of Breadfruit Leaf Extract (Artocarpus Altilis) on Fasting Blood Sugar Levels among Diabetes Mellitus (DM) Type 2 Outpatient at Biru Public Health Center of Bone Regency, Indonesia

Ulandari

Hidayanty

Jafar

et al. 2023

Biomed. Pharmacol. J.

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Diabetes is a disease that can reduce the quality of life of patients and lead to death. Based on Indonesian Basic Health research, the prevalence of diabetes mellitus has increased over several years. Breadfruit leaves contain antioxidant compounds that can lower blood sugar by inhibiting glucose transport in the gastrointestinal tract and stimulating insulin secretion in pancreatic beta cells. The study aimed to assess the effect of giving Breadfruit Leaf Extract on reducing Fasting Blood Sugar among type 2 Diabetes Mellitus Patients. The study used a quasi-experiment study with a randomized pretest-posttest, design with the control group. It involved 39 outpatients for type 2 diabetes mellitus at Biru Public Health Center of Bone Regency, who had suffered from Diabetes for 1-4 years. The sample was divided into 2 groups by simple random sampling, 19 respondents for the intervention group and 20 respondents for the control group. Data collected were the socio-demographic characteristics and fasting blood sugar levels. In the intervention group, breadfruit leaf capsules were given at a dose of 500 mg 1x1 for 21 days, while the control group was only given health education. The data were analyzed using the Chi-Square test, paired t-test, independent t-test, Wilcoxon Signed Rank Test, and Mann-Whitney. The majority of respondents aged 46-55 years were 53.8% in both groups, 74.4% were female, while the majority of BMI status had normal nutritional status as much as 41%. There was a change in FBS levels in the intervention group before (263.31 ± 134.43) and after (174.84 ± 84.99) intervention (p-value = 0.000). there was a change in FBS levels in the group before (181.35±91.36) and after (147.45 ±79.25) intervention (p-value = 0.001). it is known that there is a significant difference in changes in fasting blood sugar levels of patients with diabetes mellitus in the intervention group (-88.47±88.01) and the control group (-33.90±53.53) with (p-value = 0.024). The test results show that the content of flavonoids and other non-nutritive substances in breadfruit leaves has an effect on lowering the FBS of patients with diabetes mellitus and can be used as an alternative medicine in patients with diabetes mellitus.

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Nutrition Therapy Regulates Caffeine Metabolism with Relevance to NAFLD and Induction of Type 3 Diabetes

Cited by 39 publications

References 111 publications

Caffeine with Links to NAFLD and Accelerated Brain Aging

Caffeine with Links to NAFLD and Accelerated Brain Aging

Indian spices and Caffeine treatment for Obesity and Cardiovascular disease

The Effect of Breadfruit Leaf Extract (Artocarpus Altilis) on Fasting Blood Sugar Levels among Diabetes Mellitus (DM) Type 2 Outpatient at Biru Public Health Center of Bone Regency, Indonesia

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