Nutrition Support With Glutamine Dipeptide in Patients Undergoing Liver Transplantation

Qiu, Yudong; Lee, Seonjoo; Wang, W.; Xu, Qinhong; Ding, Yijie

doi:10.1016/j.transproceed.2009.08.076

Cited by 13 publications

(14 citation statements)

References 14 publications

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“…However, Zhu et al showed that ω-3 fatty acids supplementation, in addition to routine treatment and BCAA, was able to improve nutritional status assessed by the prognostic nutrition index [ 66 ]. Moreover, Qiu et al showed that patients receiving glutamine had a significant increase in the prognostic nutrition index [ 67 ].…”

Section: Resultsmentioning

confidence: 99%

“…Similarly, hospital LOS was significantly shorter in the group receiving ω-3 fatty acids, in addition to PN and BCAA, for 7 days after LT compared to PN and BCAA group [ 69 ]. Contradictorily, in two prospective randomized studies, adding glutamine or ω-3 fatty acids to PN after LT did not exert any additional benefits on the postoperative LOS [ 66 , 67 ]. Additionally, adding glutamine or ω-3 fatty acids to PN had no effect on 1-year or 3-year survival rates [ 66 , 67 , 69 ].…”

Section: Resultsmentioning

confidence: 99%

“…Contradictorily, in two prospective randomized studies, adding glutamine or ω-3 fatty acids to PN after LT did not exert any additional benefits on the postoperative LOS [ 66 , 67 ]. Additionally, adding glutamine or ω-3 fatty acids to PN had no effect on 1-year or 3-year survival rates [ 66 , 67 , 69 ]. The incidence of ACR was comparable between IMD + HWP and control groups in three studies conducted by Kaido et al [ 61 , 64 , 65 ].…”

Section: Resultsmentioning

confidence: 99%

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Nutritional Strategies to Manage Malnutrition and Sarcopenia following Liver Transplantation: A Narrative Review

2023

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Persisting or newly developed malnutrition and sarcopenia after liver transplant (LT) are correlated with adverse health outcomes. This narrative review aims to examine the literature regarding nutrition strategies to manage malnutrition and sarcopenia after LT. The secondary aims are to provide an overview of the effect of nutrition strategies on the incidence of infections, hospital length of stay (LOS), acute cellular rejection (ACR), and mortality after LT. Four databases were searched. A total of 25 studies, mostly of mid–high quality, were included. Six studies found a beneficial effect on nutritional parameters using branched-chain amino acids (BCAA), immunomodulating diet (IMD), or enteral nutrition (EN) whereas two studies using beta-hydroxy-beta-methylbutyrate (HMB) found a beneficial effect on muscle mass and function. Fourteen studies using pre- or pro-biotics, IMD, and EN were effective in lowering infection and six studies using IMD, BCAA or HMB reported reduced hospital LOS. Finally, four studies using HMB and vitamin D were effective in reducing ACR and one study reported reduced mortality using vitamin D after LT. In conclusion, nutritional intervention after LT has different beneficial effects on malnutrition, sarcopenia, and other advert outcomes. Additional large and well-constructed RCTs using validated tools to assess nutritional status and sarcopenia are warranted to ensure more robust conclusions.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Nutritional Strategies to Manage Malnutrition and Sarcopenia following Liver Transplantation: A Narrative Review

2023

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“…None was published before 1992. All of the studies are listed in Table 2 16 – 66 . Of these, 30 did not show any significant difference in clinical outcome between the control and intervention groups.…”

Section: Resultsmentioning

confidence: 99%

Commonly Used “Nutrition” Indicators Do Not Predict Outcome in the Critically Ill

Ferrie

Allman‐Farinelli

2013

Nut in Clin Prac

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“…The impact of nutritional interventions with immune modulating enteral diets in patients' pre-and post-LT showed possibility of improved preoperative nutritional status of ESLD patients, thus reducing infectious complications after transplantation. [75] Qiu et al [76] (2009) investigated the effect of TPN supplemented with alanyl-glutamine dipeptide in cirrhotic patients undergoing LT. Within 9 days, the group supplemented had a significant increase in the prognostic nutrition index and prealbumin levels compared with day 2 levels.…”

Section: Immunonutritionmentioning

confidence: 99%

Diet and nutrition therapy in pre-liver transplant patients

Bakshi¹,

Singh²

2016

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Malnutrition is universally prevalent among pre-liver transplantation patients. Malnutrition among cirrhotic patients had been associated to increased morbidity and mortality rates. Also, severely malnourished patients before the transplant surgery have a higher rate of complications and a decreased overall survival rate after liver transplantation. In light of the high incidence of malnutrition and associated complications, it is essential to initiate treatment as early as it is assessed. This review addresses the aetiologies of malnutrition and appropriate treatment strategies to correct it in pre-liver transplant phase. Treatment should focus on maintaining nutrient intake and correcting various nutritional deficiencies. The dietician plays an integral role as part of the transplant team by providing appropriate nutrition therapy for solving various nutrition problems.

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Nutrition Support With Glutamine Dipeptide in Patients Undergoing Liver Transplantation

Cited by 13 publications

References 14 publications

Nutritional Strategies to Manage Malnutrition and Sarcopenia following Liver Transplantation: A Narrative Review

Nutritional Strategies to Manage Malnutrition and Sarcopenia following Liver Transplantation: A Narrative Review

Commonly Used “Nutrition” Indicators Do Not Predict Outcome in the Critically Ill

Diet and nutrition therapy in pre-liver transplant patients

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