Clinical Nutrition 2013
DOI: 10.1201/b16308-18
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Abstract: Over the last years, evidence has accumulated suggesting that by systematically reducing the amount of dietary carbohydrates (CHOs) one could suppress, or at least delay, the emergence of cancer, and that proliferation of already existing tumor cells could be slowed down. This hypothesis is supported by the association between modern chronic diseases like the metabolic syndrome and the risk of developing or dying from cancer. CHOs or glucose, to which more complex carbohydrates are ultimately digested, can hav… Show more

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Cited by 18 publications
(26 citation statements)
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“…Subsequently, numerous studies have consistently demonstrated that energy restriction could inhibit the development of a variety of spontaneous and induced tumors in rats and mice as well as non-human primates (Hursting et al, 2003;Zhu et al, 2003;Hursting et al, 2010;Klement et al, 2011). The essential biological rationale for anti-cancer effect of energy restriction would be endocrine regulation of cancer by insulin-like signals, which in turn may repress cell proliferation, disturb cell cycle, induce apoptosis and impair neovasculation of tumor tissue (Jiang et al, 2002;Zhu et al, 2003).…”
Section: Discussionmentioning
confidence: 99%
“…Subsequently, numerous studies have consistently demonstrated that energy restriction could inhibit the development of a variety of spontaneous and induced tumors in rats and mice as well as non-human primates (Hursting et al, 2003;Zhu et al, 2003;Hursting et al, 2010;Klement et al, 2011). The essential biological rationale for anti-cancer effect of energy restriction would be endocrine regulation of cancer by insulin-like signals, which in turn may repress cell proliferation, disturb cell cycle, induce apoptosis and impair neovasculation of tumor tissue (Jiang et al, 2002;Zhu et al, 2003).…”
Section: Discussionmentioning
confidence: 99%
“…As a result, 'calorie restriction' remains popular among approaches to cancer control [129]. We therefore re-emphasize that the insulin/IGF-1 pathway is activated principally by dietary consumption of CHO, and glucose is most often the preferred energy substrate for cancer cells due to metabolic dysfunction, as described above [90,130,10]. Protein consumption also stimulates this pathway albeit to a lesser extent than glucose in humans [20].…”
Section: Cell Signaling Pathwaysmentioning
confidence: 99%
“…Studies of CR in humans have generally addressed cancer treatment [6][7][8][9] but, most recently, carbohydrate-restricted diets, ketogenic diets, and so-called paleo diets which have de facto reduction of carbohydrate (CHO) as a common feature, have shown much promise for prevention [10]. It is understood, however that the discussion has outstripped both understanding of underlying mechanisms and the limited experimental support [11].…”
Section: Introductionmentioning
confidence: 99%
“…Cruciferous vegetables, such as broccoli, Brussels sprouts and cauliflower, are rich in powerful glucosinolates, which break down to form isothiocyanates that can cause cancer cells to commit suicide [14].…”
Section: Complementary Nutritional Elements In Cancer Therapymentioning
confidence: 99%