Nutrition Status and Intestinal Permeability in Patients Eligible for Liver Transplantation

Abstract

Although intestinal permeability was increased in cirrhotic patients, this finding was not associated with nutrition status.

Duodenal Morphometry and Small Bowel Permeability in Children With Portal Hypertension

“…Weight and height z scores revealed severe degree of nutritional compromise (À2), and triceps skin-fold thickness showed low fat stores in patients with PHT. Similar results have been reported by Taylor et al (7) and Liberodo et al (37), suggesting that SIP probably is not a significant independent factor that contributes to nutritional compromise in children with PHT. We observed no differences in intake of calories and protein among our patients with PHT and healthy controls, demonstrating that nutritional compromise in our patients was came from an intrinsic cause.…”

Response to Comment on ‘Nutrition Screening vs Nutrition Assessment: What's the Difference?’

“…In summary, I would like to reinforce my full support and defense of SGA as an outstanding assessment instrument, which has also been shown to be of prognostic value …”

“…Historically, ever since our first study on the prevalence of hospital malnutrition published in Nutrition , we have defended SGA as the gold standard method to diagnose malnutrition among different groups of patients in the hospital or outpatient setting . It is notable that our study mentioned above was rejected by 2 well‐known medical journals, with the justification that the assessment tool was “subjective” and, thus, could not support the diagnoses we presented.…”

“…It is notable that our study mentioned above was rejected by 2 well‐known medical journals, with the justification that the assessment tool was “subjective” and, thus, could not support the diagnoses we presented. Furthermore, we have frequently faced criticisms by reviewers who demand objective nutrition assessment instruments as part of the evaluation process in research articles from our group . In our replies, we have added such information because it is part of our routine to use many of these markers, but we refute the opinions and suggestions to refrain from using SGA as our gold standard tool.…”

Evaluation of the Behavior of Levels of Hmgb1 and Il6 as Predictors of Infection, Acute Kidney Injury and Mortality in Cirrhotic Patients With Variceal Bleeding

“…At the epithelial level, specifically in the small intestine, patients with liver cirrhosis present changes in barrier function. Increased intestinal permeability has been found in cirrhotic patients compared with healthy controls (7,8) . This increased permeability appears to be a result of the loosening of tight junctions associated not only with increased resistance to portal venous flow but also as a result of systemic circulatory dysfunction (9,10) .…”