Nutrition, operations, and intestinal adaptation

Bristol, JB; Rc, Williamson

doi:10.1177/0148607188012003299

Cited by 56 publications

(22 citation statements)

References 5 publications

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“…Enteroglucagon plays a major role in modulating the compensatory hyperplasia seen in the remaining small bowel after partial enterectomy (Bristol & Williamson, 1988). The duodenum participates in this adaptive response to proximal small bowel resection (Williamson & Bauer, 1978;Urban et (Stewart et al, 1991), probably because severe weight loss and malabsorption suppressed carcinogenesis (Roebuck et al, 1981b).…”

Section: Other Specific Dietary Constituentsmentioning

confidence: 99%

Experimental pancreatic hyperplasia and neoplasia: effects of dietary and surgical manipulation

Watanapa

Williamson²

1993

Br J Cancer

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Summary Several studies carried out during the past two decades have investigated the effect of dietary and surgical manipulation on pancreatic growth and carcinogenesis. Diets high in trypsin inhibitor stimulate pancreatic growth and increase the formation of preneoplastic lesions and carcinomas in the rat pancreas. Cholecystokinin (CCK) is the key intermediary in this response, since both natural and synthetic trypsin inhibitors increase circulating levels of the hormone and CCK antagonists largely prevent these changes. Fatty acids enhance pancreatic carcinogenesis in both rats and hamsters, whereas protein appears to have a protective role in the rat, but to increase tumour yields in the hamster. Several surgical operations affect the pancreas. Pancreatobiliary diversion and partial gastrectomy stimulate pancreatic growth and enhance carcinogenesis, probably by means of increased CCK release. Complete duodenogastric reflux has similar effects on the pancreas but the gut peptide involved is gastrin. Although massive small bowel resection increases pancreatic growth, the marked reduction in caloric absorption probably explains its failure to enhance carcinogenesis. CCK and enteroglucagon might work in concert to modulate the tropic response of the pancreas to small bowel resection. In the pancreas, as in the large intestine, hyperplasia appears to precede and predispose to neoplasia.

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Section: Other Specific Dietary Constituentsmentioning

confidence: 99%

Experimental pancreatic hyperplasia and neoplasia: effects of dietary and surgical manipulation

Watanapa

Williamson²

1993

Br J Cancer

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“…In the rodent model of massive small bowel resection (SBR), the residual small intestine (both jejunum and/or ileum) undergoes a series of adaptive processes leading to a significant increase in intestinal absorptive surface area which reflects regulatory processes for reestablishment of the nutritional homeostasis of the body the exact mechanisms of which are still poorly understood (3)(4)(5). The degree of intestinal adaptation has been shown to depend on the amount of the resected tissue and also on the site of intestinal resection (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Influence of the site of small bowel resection on intestinal epithelial cell apoptosis

et al. 2005

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“…Tube feeding (TF) is to be preferred over parenteral nutrition (PN) provided the alimentary tract is functional, because of its more physiological character. It helps to maintain the integrity of the gastrointestinal tract, reduces potential bacterial translocation, and is associated with minimal complications [6][7][8][9][10][11][12]. Furthermore, TF is relatively inexpensive compared to PN [13].…”

Section: Introductionmentioning

confidence: 99%