Nutrition intervention is beneficial to the quality of life of patients with gastrointestinal cancer undergoing chemotherapy in Vietnam

Nguyen, Linh Thuy; Dang, Anh Kim; Duong, Phuong Thi; Phan, Hanh Bich Thi; Pham, Chinh Tuyet Thi; Nguyen, Anh Tuan; Le, Huong Thi

doi:10.1002/cam4.3766

Cited by 21 publications

(18 citation statements)

References 55 publications

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“…In the present study, we showed that intensive nutrition counselling commencing at diagnosis and continuing for 18 weeks had no marked impact on QoL over 12 months. Only a few published studies are available to understand the impact of nutrition counselling interventions on changes in QoL in people undergoing treatment for cancer, and the results are conflicting [ 15 , 34 , 35 , 36 ]. An RCT tested a three-month nutrition intervention plus three-month follow-up in cancer outpatients and found no significant difference in QoL or nutritional status between intervention ( n = 30) and control groups ( n = 28), despite achieving a higher protein and energy intake [ 36 ]; this study also had a high withdrawal rate.…”

Section: Discussionmentioning

confidence: 99%

“…An RCT tested a three-month nutrition intervention plus three-month follow-up in cancer outpatients and found no significant difference in QoL or nutritional status between intervention ( n = 30) and control groups ( n = 28), despite achieving a higher protein and energy intake [ 36 ]; this study also had a high withdrawal rate. In contrast, a quasi-experimental trial of a two-month nutrition intervention for people with gastric or colon cancer ( n = 53), commencing during an inpatient stay, found improved global QoL (EORTC QLQ-C30) and improvements in scores of physical functioning and role functioning compared with the control group ( n = 50) [ 35 ]. Similarly, a 12-week RCT in people with gastrointestinal or head and neck cancer receiving radiotherapy found that intensive nutrition counselling ( n = 29) mitigated weight loss and improved global QoL scores and physical function scale scores (EORTC QLQ-C30) compared with the control group ( n = 31) [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

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Effect of Early and Intensive Telephone or Electronic Nutrition Counselling Delivered to People with Upper Gastrointestinal Cancer on Quality of Life: A Three-Arm Randomised Controlled Trial

et al. 2022

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Background: Delay in dietetic service provision for upper gastrointestinal cancer exacerbates disease-related malnutrition and consequently increases morbidity and mortality. Dietetic services are usually referral-based and provided face-to-face in inpatient or outpatient settings, which can delay the commencement of nutrition care. The aim of this study was to provide intensive dietetic intervention close to the time of diagnosis for upper gastrointestinal cancer and assess the effect on quality-adjusted life years. Methods: A three-arm randomised controlled trial of adults newly diagnosed with upper gastrointestinal cancer was performed. A behavioural-based, individually tailored, symptom-directed nutrition intervention was provided in addition to usual care, delivered by a dietitian using a telephone (synchronously) or a mobile application (asynchronously) for 18 weeks, compared with a usual care control group. Data were collected at baseline, three, six, and twelve months post-randomisation. The primary outcome was quality-adjusted life years (EQ-5D-5L quality of life assessment tool). Data were analysed using linear mixed models. Results: One hundred and eleven participants were randomised. Quality-adjusted life years were not different in the intervention groups compared with control (telephone: mean (95% CI) 0.04 (0.43, 2.3), p = 0.998; App: −0.08 (−0.18, 0.02), p = 0.135) after adjustment for baseline, nutrition risk status, age, and gender. Survival was similar between groups over 12 months. The asynchronous mobile app group had a greater number of withdrawals compared with the telephone group. Conclusion: Early and intensive nutrition counselling, delivered at home, during anticancer treatment did not change quality-adjusted life years or survival over 12 months compared with usual care. Behavioural counselling alone was unable to achieve nutritional adequacy. Dietetic services delivered asynchronously using a mobile app had low acceptance for patients undergoing anticancer treatment. Trial Registration: 27 January 2017 Australian and New Zealand Clinical Trial Registry, ACTRN12617000152325.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of Early and Intensive Telephone or Electronic Nutrition Counselling Delivered to People with Upper Gastrointestinal Cancer on Quality of Life: A Three-Arm Randomised Controlled Trial

et al. 2022

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“…While these patients are prone to malnutrition and weight loss during their treatment, many are overweight due to obesity being a major risk factor for cancers of the colon, rectum, esophagus, liver, and pancreas [ 71 ]. Nguyen et al examined how nutritional interventions improved the QoL in patients with GI cancer who were undergoing CT in Vietnam [ 36 ] ( Table 1 ). Patients with early-stage GI cancers tend to be asymptomatic and thus this disease tends to be detected later with a poorer prognosis [ 72 ].…”

Section: Discussionmentioning

confidence: 99%

“…As a result, QoL is an important endpoint that is used to assess the treatment outcomes among those with GI cancers [ 65 ]. When GI patients received high-protein and energy-rich diets, they had higher QoL scores when they were compared to those of the control as well as reduced adverse effects from their CT regimen [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Dietary Interventions in Cancer Treatment and Response: A Comprehensive Review

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Tizpa

Philip

et al. 2022

Cancers

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Chemotherapy and radiotherapy are first-line treatments in the management of advanced solid tumors. Whereas these treatments are directed at eliminating cancer cells, they cause significant adverse effects that can be detrimental to a patient’s quality of life and even life-threatening. Diet is a modifiable risk factor that has been shown to affect cancer risk, recurrence, and treatment toxicity, but little information is known how diet interacts with cancer treatment modalities. Although dietary interventions, such as intermittent fasting and ketogenic diets, have shown promise in pre-clinical studies by reducing the toxicity and increasing the efficacy of chemotherapeutics, there remains a limited number of clinical studies in this space. This review surveys the impact of dietary interventions (caloric restriction, intermittent and short-term fasting, and ketogenic diet) on cancer treatment outcomes in both pre-clinical and clinical studies. Early studies support a complementary role for these dietary interventions in improving patient quality of life across multiple cancer types by reducing toxicity and perhaps a benefit in treatment efficacy. Larger, phase III, randomized clinical trials are ultimately necessary to evaluate the efficacy of these dietary interventions in improving oncologic or quality of life outcomes for patients that are undergoing chemotherapy or radiotherapy.

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“…They could freely select their own diet. In contrast, patients in the intervention group were treated with the intervention regimen, which consisted of: (1) nutritional counseling; (2) hospital meals: each patient was assigned a specific menu prepared by research members during the time of staying at the hospital; (3) instruction on food preparation at home: before discharge, patients were instructed on preparing their diet at home with high energy and protein intake as recommended and given formula milk (6 teaspoons, equivalent to 54 g of powdered milk with 180 mL warm water per time) within two months [ 20 ]. To monitor the intervention process, the dieticians continuously evaluated the daily diet of each patient during hospitalization and tele-counseling every two weeks for weight monitoring and nutritional support advice after discharge.…”

Section: Methodsmentioning

confidence: 99%

Nutritional Intervention Improves Nutrition Outcomes in Stomach and Colon Cancer Patients Receiving Chemotherapy: Finding from a Quasi-Experiment in Vietnam

et al. 2021

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Background: Evidence on the effects of nutritional interventions on gastrointestinal cancer patients receiving chemotherapy is not well documented. This study aims to assess the effects of nutritional intervention in patients diagnosed with stomach and colon cancer receiving chemotherapy in Vietnam. Methods: A quasi-experiment with intervention and control groups for pre- and post-intervention was carried out in cancer patients receiving chemotherapy in a university hospital in Vietnam. Patients in the intervention group were provided nutritional counseling, personalized specific dietary advice, and received oral nutrition supplements (ONSs) while patients in the control group only received nutrition counseling. Results: The weight in the intervention and control group after 2 months increased significantly by 1.4 ± 2.6 kg and 0.4 ± 2.3 kg, respectively. Muscle mass increased by 1.2 ± 4.1 cm in the intervention group, while those in the control group decreased by 0.55 ± 2.77 cm. There was no statistical significance between two groups after intervention in terms of Mid–Upper Arm Circumference (MUAC) and percentage of fat. The percentage of malnutrition based on the Scored Patient-Generated Subjective Global Assessment (PG-SGA) and Body Mass Index (BMI) declined after the intervention in both groups. According to the average treatment effect on the treated (ATT) using the propensity score matching and DiD method, participants receiving the intervention were more likely to have a higher score of weight (Coef = 0.84; 95%CI = 0.47; 2.16) and muscle mass (Coef = 1.08; 95%CI = 0.09; 2.06) between pre- and post-intervention. By contrast, the PG-SGA scores on treated participants were more likely to decrease after the intervention (Coef = −1.28; 95%CI = −4.39; −0.84). After matching, being female, living in rural areas, or having stomach cancer were still positively related to being moderately/severely malnourished by the PG-SGA, and these findings were statistically significant (p < 0.05). Conclusion: The nutritional interventions had a positive effect on weight gain, muscle mass, and reduced malnutrition. Further studies with a longer follow-up duration are needed to confirm the effects of the intervention.

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Nutrition intervention is beneficial to the quality of life of patients with gastrointestinal cancer undergoing chemotherapy in Vietnam

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 21 publications

References 55 publications

Effect of Early and Intensive Telephone or Electronic Nutrition Counselling Delivered to People with Upper Gastrointestinal Cancer on Quality of Life: A Three-Arm Randomised Controlled Trial

Effect of Early and Intensive Telephone or Electronic Nutrition Counselling Delivered to People with Upper Gastrointestinal Cancer on Quality of Life: A Three-Arm Randomised Controlled Trial

Dietary Interventions in Cancer Treatment and Response: A Comprehensive Review

Nutritional Intervention Improves Nutrition Outcomes in Stomach and Colon Cancer Patients Receiving Chemotherapy: Finding from a Quasi-Experiment in Vietnam

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