Nutrition in Asthma

Williams, Evan J.; Berthon, Bronwyn S.; Stoodley, Isobel; Williams, Lily M.; Wood, Lisa G.

doi:10.1055/s-0042-1742385

Cited by 5 publications

(3 citation statements)

References 186 publications

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“…There is growing evidences that diet plays a big role in the development and treatment of asthma [ 5 ]. Diet, a modifiable factor, can be essential to decrease incidence of asthma in primary preventive measures [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Consumption of milk and dairy products and risk of asthma in children: a systematic review and Meta-analysis

et al. 2023

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Background Some reports demonstrate that asthma benefits from milk and dairy products, however, the findings are controversial. We used meta-analysis as a tool to summarize published data on the association between dairy products consumption and asthma. Methods A systematic literature search was conducted to identify studies of dairy products and asthma in children in PubMed, ISI (Web of Science), and EMBASE until 21 July 2022. Random-effect meta-analyses with summarized data were performed for total (high/low) milk and dairy intake. Subgroup analysis was used to identify sources of variation in responses. Publication bias and sensitivity analysis were done to examine the stability of results. Results There was no correlation between consumption of dairy products and reduced risk of asthma (OR = 0.82; 95% CI: 0.60–1.05). Our results revealed that elevated consumption of milk and dairy has significant correlation with reduced risk of asthma in Non-Asian population (OR = 0.74; 95% CI = 0.51–0.96) and high quality studies (OR = 0.73; 95% CI = 0.50–0.95). No individual study influence and publication bias was seen in the sensitivity analysis and publication bias assessment. Conclusion There was no correlation between consumption of dairy products and reduced risk of asthma. However, we observed that elevated consumption of milk and dairy has significant correlation with reduced risk of asthma in Non-Asian population and high quality studies. More high-quality and population-specific studies should be conducted to determine the risk link between milk consumption and asthma in children.

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Section: Introductionmentioning

confidence: 99%

Consumption of milk and dairy products and risk of asthma in children: a systematic review and Meta-analysis

et al. 2023

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“… 15 A 15-year interval study in the UK showed that Omega-6 fatty acid levels and Omega-3 fatty acid consumption increased as childhood asthma increased. 16 , 17 In contrast, fat is an essential component of a healthy diet for children, but the proper sources and composition of fat for children should be further investigated. 18 Moreover, a novel approach exploring the whole diet patterns and diet diversity has been proposed.…”

Section: Introductionmentioning

confidence: 99%

The Effects of a Healthy Diet on Asthma and Wheezing in Children and Adolescents: A Systematic Review and Meta-Analysis

Zhang,

He,

et al. 2023

JAA

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Background Asthma is a public health problem requiring focused attention. This study aimed to systematically evaluate the association between dietary structure and asthma or wheezing in children. Methods The study protocol of this meta-analysis has been registered in the International Prospective Register of Systematic Reviews (PROSPERO) with the registration code CRD42023390191. A total of 8397 articles were retrieved, searching PubMed, Medline, Embase, Web of Science, and Scopus databases as of November 21, 2022. Two independent authors were responsible for independently conducting the literature screening process. Effect-size estimates were expressed as odds ratio (OR) in cross-sectional studies and risk ratio (RR) in cohort studies with a 95% confidence interval (CI). Summary effect estimates were evaluated with random-effect models. Meanwhile, subgroup and sensitivity analyses were performed to assess the potential sources of heterogeneity and the robustness of the pooled estimation. Results A total of 65 studies, including 567,426 subjects had been analyzed. Overall analyses of cross-sectional studies revealed that a healthy diet was protective against asthma (adjusted OR=0.85, 95% CI: 0.80–0.89, P <0.001, I 2 =69.8%, Tau 2 =0.026) and wheezing (adjusted OR=0.85, 95% CI: 0.81–0.89, P <0.001, I 2 =66.8%, Tau 2 =0.015) in children and adolescents. Conversely, unhealthy diets can exacerbate asthma (adjusted OR=1.28, 95% CI: 1.20–1.36, P <0.001, I 2 =64.9%, Tau 2 =0.019) and wheeze (adjusted OR=1.09, 95% CI: 1.02–1.16, P =0.006, I 2 =75.2%, Tau 2 =0.023) in children and adolescents. The same trend was found in cohort studies (adjusted RR=0.72, 95% CI: 0.58–0.90, P =0.003, I 2 =83.5%, Tau 2 =0.105). A clear trend was observed between high-frequency healthy diets (OR=0.80; 95% CI: 0.71–0.89; P <0.001) is more protective against asthma than low-frequency healthy diets (OR=0.81; 95% CI: 0.70–0.94; P =0.007). Conclusion Our findings highlight the protective effects of a healthy diet on asthma and wheezing in children, including fruit, seafood, cereals, and the Mediterranean diet.

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“…Firstly, asthma inception, development and severity are influenced by an interacting host of genetic factors (Berube & Bosse, 2014 ) and inhaled offending triggers that vary in concentration and constitutional composition over time (Sheehan et al., 2017 ; Szram & Cullinan, 2012 ). The impact of these interactions also depends on the timing (e.g., age, menstrual cycle, pregnancy) and sequence of exposure throughout life (Tang et al., 2021 ), in addition to the diet (Williams et al., 2022 ), the lung and gut microbiota (Barcik et al., 2020 ; Tang et al., 2021 ), the presence of obesity (Tooba & Wu, 2022 ) and other co‐morbidities (Cazzola et al., 2022 ; Teodorescu et al., 2015 ), the current and historical intake of medications (Tan et al., 2021 ), the air temperature (Zhou et al., 2022 ), and levels of anxiety (Ye et al., 2021 ), physical activity (Kuder et al., 2021 ), sunshine (Alfredsson et al., 2020 ) and ambient oxygen (altitude) (de Nijs et al., 2020 ; Vinnikov et al., 2016 ). Secondly, investigations of humans in vivo rely on non‐invasive methods that lack precision (Bates & Irvin, 2003 ).…”

Section: Introductionmentioning

confidence: 99%

More airway smooth muscle in males versus females in a mouse model of asthma: A blessing in disguise?

Gill

Rojas‐Ruiz

Boucher

et al. 2023

Experimental Physiology

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Mouse models are helpful in unveiling the mechanisms underlying sex disparities in asthma. In comparison to their female counterparts, male mice are hyperresponsive to inhaled methacholine, a cardinal feature of asthma that contributes to its symptoms. The physiological details and the structural underpinnings of this hyperresponsiveness in males are currently unknown. Herein, BALB/c mice were exposed intranasally to either saline or house dust mite once daily for 10 consecutive days to induce experimental asthma. Twenty-four hours after the last exposure, respiratory mechanics were measured at baseline and after a single dose of inhaled methacholine that was adjusted to trigger the same degree of bronchoconstriction in both sexes (it was twice as high in females). Bronchoalveolar lavages were then collected, and the lungs were processed for histology. House dust mite increased the number of inflammatory cells in bronchoalveolar lavages to the same extent in both sexes (asthma, P = 0.0005; sex, P = 0.96). The methacholine response was also markedly increased by asthma in both sexes (e.g., P = 0.0002 for asthma on the methacholine-induced bronchoconstriction). However, for a well-matched bronchoconstriction between sexes, the increase in hysteresivity, an indicator of airway narrowing heterogeneity, was attenuated in males for both control and asthmatic mice (sex, P = 0.002). The content of airway smooth muscle was not affected by asthma but was greater in males (asthma, P = 0.31; sex, P < 0.0001). These results provide further insights regarding an important sex disparity in mouse models of asthma. The increased amount of airway smooth muscle in males might contribute functionally to their greater methacholine response and, possibly, to their decreased propensity for airway narrowing heterogeneity.

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Nutrition in Asthma

Cited by 5 publications

References 186 publications

Consumption of milk and dairy products and risk of asthma in children: a systematic review and Meta-analysis

Consumption of milk and dairy products and risk of asthma in children: a systematic review and Meta-analysis

The Effects of a Healthy Diet on Asthma and Wheezing in Children and Adolescents: A Systematic Review and Meta-Analysis

More airway smooth muscle in males versus females in a mouse model of asthma: A blessing in disguise?

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