Nutrition, Healthcare Benefits and Phytochemical Properties of Cassava (Manihot esculenta) Leaves Sourced from Three Countries (Reunion, Guinea, and Costa Rica)

Abstract

(1) Background: Manihot esculenta, cassava, is an essential food crop for human consumption in many parts of the world. Besides the wide use of its roots, cassava leaves have been used locally as green vegetables and for medicinal purposes. However, nutritional health data regarding cassava leaves is limited, therefore we investigated its composition and associated potential bioactivity interest for human health. (2) Methods: Cassava leaf bioactivity investigations focused on antioxidant properties (free radical scavenging) in association with immunomodulatory activities on inflammatory murine macrophages to measure the impact of cassava extract on the production of pro-inflammatory cytokines such as Interleukin-6, Tumor Necrosis Factor alpha, Monocyte Chemoattractant Protein-1, Prostaglandin-E2 and mediators such as nitric oxide. (3) Results: Antioxidant and immunomodulatory bioactivities were significant, with a concentration-dependent inhibition of cytokines production by inflammatory macrophages; (4) Conclusions: Taken together, our results tend to suggest that Manihot esculenta leaves might be underrated regarding the potential nutrition-health interest of this vegetal matrix for both human nutrition and prophylaxis of metabolic disease with underlying low grade inflammation status.

Immunomodulatory and Antioxidant Properties of Ipomoea batatas Flour and Extracts Obtained by Green Extraction

“…The presence of nitrite, a stable oxidized product of nitric oxide, was determined in the cell culture media as previously described [ 43 ]. Briefly, 100 μL of supernatant were combined with 100 μL of Griess reagent in a 96-well plate, and then incubated for 10 min at room temperature.…”

Blood Metabolites, Feed Utilization and Performance in Thai Native X Lowline Angus Crossbred Cattle Fed Cassava Byproducts

“…Furthermore, yeast-derived products contain 28 g/day of yeast culture plus enzymatically hydrolyzed Saccharomyces cerevisiae, suitable for rumen health and animal health maintenance (Faccio-Demarco et al, 2019). The cassava leaves contained a high cyanide content and were unsafe for animal consumption without appropriate processing methods (Ayele et al, 2022;Boukhers et al, 2022). Meanwhile, sundried or fermented cassava leaves can reduce toxic contents and improve nutrients (Morgan and Choct, 2016).…”

Steroid Compounds of Manihot Esculenta Crantz Var. Sao Pedro Petro (Tuber) and Their Cytotoxic Effects on Melanoma Cancer Cells (B16-F10)

“…Cassava can serve as both a nutritional food source and a therapeutic plant due to its nutrient makeup. It is often farmed as an annual crop in tropical and subtropical countries, largely for its starchy tuberous roots, which are an essential supply of carbohydrates [4,5].…”