Nutrition during pregnancy: Influence on the gut microbiome and fetal development

Barrientos, Gabriela; Ronchi, Francesca; Conrad, Melanie L.

doi:10.1111/aji.13802

Cited by 3 publications

(1 citation statement)

References 120 publications

(230 reference statements)

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“…The gut microbiome is formed during fetal life [ 46 ] and its composition is influenced by many factors, including mode of delivery, medications, breast-feeding, formula feeding, maternal diet, maternal health, and perinatal weight. The mother’s gut microbiota therefore influences the growth and development of her baby [ 47 ].…”

Section: Maternal Choline and Gut Microbiotamentioning

confidence: 99%

Choline—An Underappreciated Component of a Mother-to-Be’s Diet

Dymek,

Oleksy,

Stolarczyk

et al. 2024

Nutrients

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The nutritional status of the mother-to-be has a key impact on the proper development of the fetus. Although all nutrients are important for the developing baby, recent research indicates the importance of adequate choline intake during the periconceptional period, pregnancy, and lactation. Choline plays a key role in the biosynthesis of cell membranes, supporting liver function, neurotransmission, brain development, and DNA and histone methylation. Choline participates in the formation of a child’s nervous system, supports its cognitive development, and reduces the risk of neural tube defects. The human body is incapable of producing sufficient choline to meet its needs; therefore, it must be obtained from the diet. Current data indicate that most women in their reproductive years do not achieve the recommended daily intake of choline. The presented narrative review indicates the importance of educating mothers-to-be and thereby increasing their awareness of the effects of choline on maternal and child health, which can lead to a more aware and healthy pregnancy and proper child development.

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Section: Maternal Choline and Gut Microbiotamentioning

confidence: 99%

Choline—An Underappreciated Component of a Mother-to-Be’s Diet

Dymek,

Oleksy,

Stolarczyk

et al. 2024

Nutrients

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Maternal influences on offspring food allergy

Lee,

Nazmul,

Lan

et al. 2024

Immunological Reviews

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SummaryThe prevalence of allergies has been globally escalating. While allergies could appear at any age, they often develop in early life. However, the significant knowledge gap in the field is the mechanisms by which allergies affect certain people but not others. Investigating early factors and events in neonatal life that have a lasting impact on determining the susceptibilities of children to develop allergies is a significant area of the investigation as it promotes the understanding of neonatal immune system that mediates tolerance versus allergies. This review focuses on the research over the recent 10 years regarding the potential maternal factors that influence offspring allergies with a view to food allergy, a potentially life‐threatening cause of anaphylaxis. The role of breast milk, maternal diet, maternal antibodies, and microbiota that have been suggested as key maternal factors regulating offspring allergies are discussed here. We also suggest future research area to expand our knowledge of maternal–offspring interactions on the pathogenesis of food allergy.

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Gut Microbiota and Other Factors Associated With Increased Regulatory T Cells in Hiv-exposed Uninfected Infants

Johnson,

Lazarus,

Bennett

et al. 2024

Preprint

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HIV-exposed uninfected infants (HEU) have higher infectious morbidity than HIV-unexposed infants (HUU). HEU have multiple immune defects of unknown origin. We hypothesized that HEU have higher regulatory T cells (Treg) than HUU, which may dampen their immune defenses against pathogens. We compared 25 Treg subsets between HEU and HUU and sought the factors that may affect Treg frequencies. At birth, 3 Treg subsets, including CD4 + FOXP3 + and CD4 + FOXP3 + CD25+, had higher frequencies in 123 HEU than 117 HUU and 3 subsets were higher in HUU. At 28 and 62 weeks of life, 5 Treg subsets were higher in HEU, and none were higher in HUU. The frequencies of the discrepant Treg subsets correlated at birth with differential abundances of bacterial taxas in maternal gut microbiome and at subsequent visits in infant gut microbiomes. In vitro, bacterial taxa most abundant in HEU expanded Treg subsets with higher frequencies in HEU, recapitulating the in vivo observations. Other factors that correlated with increased Treg were low maternal CD4 + T cells in HEU at birth and male sex in HUU at 28 weeks. We conclude that maternal and infant gut dysbiosis are central to the Treg increase in HEU and may be targeted by mitigating interventions.

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Nutrition during pregnancy: Influence on the gut microbiome and fetal development

Cited by 3 publications

References 120 publications

Choline—An Underappreciated Component of a Mother-to-Be’s Diet

Choline—An Underappreciated Component of a Mother-to-Be’s Diet

Maternal influences on offspring food allergy

Gut Microbiota and Other Factors Associated With Increased Regulatory T Cells in Hiv-exposed Uninfected Infants

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