Nutrition as prevention and treatment of osteoporosis

Stransky, M.; Rysavá, L

doi:10.33549/physiolres.931858

Cited by 38 publications

(16 citation statements)

References 3 publications

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“…It is important to remember nevertheless that although the deterioration of the body during the aging process renders the older adult particularly susceptible to poor bone health, osteoporosis should not be considered a disease exclusively pertaining to elderly individuals as it globally affects millions of men and women of all ages and ethnicities (38,39). Bone mass is influenced by factors such as sex, hormones, as well as genetic and environmental variables and last, but not least, nutrition.…”

Section: Fruitmentioning

confidence: 99%

Soilless biofortification, bioaccessibility, and bioavailability: Signposts on the path to personalized nutrition

et al. 2022

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Propelled by an ever-growing awareness about the importance of following dietary recommendations meeting specific biological requirements linked to a person health status, interest in personalized nutrition is on the rise. Soilless biofortification of vegetables has opened the door to the potential for adapting vegetable production to specific dietary requirements. The evolution of vegetables biofortification toward tailored food is examined focusing on some specific categories of people in a context of personalized nutrition instead to simple describe developments in vegetables biofortification with reference to the single element or compound not adequately present in the daily diet. The concepts of bioavailability and bioaccessibility as a useful support tool for the precision biofortification were detailed. Key prospects for challenges ahead aiming to combine product quality and sustainable are also highlighted. Hydroponically cultivation of vegetables with low potassium content may be effective to obtain tailored leafy and fruit vegetable products for people with impaired kidney function. Simultaneous biofortification of calcium, silicon, and boron in the same vegetable to obtain vegetable products useful for bone health deserve further attention. The right dosage of the lithium in the nutrient solution appears essential to obtain tailored vegetables able to positively influence mental health in groups of people susceptible to mental illness. Modulate nitrogen fertilization may reduce or enhance nitrate in vegetables to obtain tailored products, respectively, for children and athletes. Future research are needed to produce nickel-free vegetable products for individuals sensitized to nickel. The multidisciplinary approach toward tailored foods is a winning one and must increasingly include a synergy between agronomic, biological, and medical skills.

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Section: Fruitmentioning

confidence: 99%

Soilless biofortification, bioaccessibility, and bioavailability: Signposts on the path to personalized nutrition

et al. 2022

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“…Previous in vivo and in vitro studies showed that boron has a wide variety of biological activities such as anti-osteoporotic [14], antioxidant [15,16], a regulator of the immune system [17,18], mineral and vitamin metabolism [19]. and steroid hormone metabolism [20,21].…”

Section: Introductionmentioning

confidence: 99%

Effects of Boric Acid on Invasion, Migration, Proliferation, Apoptosis, Cell Cycle and miRNAs in Medullary Thyroid Cancer Cells

Yıldırım

Seçme

Dodurga

et al. 2021

Preprint

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Background: Medullary thyroid cancer (MTC), which makes up 5-10% of all thyroid cancers, is a highly aggressive and chemotherapeutically resistant cancer originating from parafollicular C cells of the thyroid. In recent years, testing of new biological, chemical or natural compounds as an alternative to existing agents used in cancer treatment has been a popular research topic. One of these compounds is boric acid originating from the element boron, and studies have shown that it has anti-carcinogenic, anti-osteoporotic and anti-oxidant effects. Purpose: The aim of this study is to determine the therapeutic effects of boric acid on cell proliferation, invasion, migration, colony formation, cell cycle and apoptosis mechanisms in TT medullary thyroid cancer cell line under in vitro conditions.Methodology: The effects of boric acid on cell viability was determined by XTT assay. Total RNA was isolated by Trizol reagent. Gene and miRNA expressions were analyzed by RT-PCR. Effects of boric acid on apoptosis were analyzed by TUNEL assay and genotoxicity was performed by comet assay. Effects of boric acid on cell invasion, colony formation and cell migration were detected by matrigel-chamber, colony formation assay and wound healing assay, respectively. Results: In order to determine the effect of boric acid on cell viability and 50% lethal dose, the XTT method was employed and IC50 dose was found to be 35 μM at 48th hour. A real-time PCR test was used to investigate changes in cell cycle and apoptosis related genes and proteins and identified miRNAs under the addition of boric acid. In addition, miR-21 was significantly reduced in medullary thyroid cancer associated with cancer aggressiveness and poor prognosis. Using the Tunnel test, the apoptosis rate in the dose group cells were found as 14%. Matrigel invasion test showed a 30.8% decrease in invasion in the dose group and colony formation test decreased 67.9% in the dose group. Using the wound healing assay, it has been found that migration was reduced, and the Comet assay has shown that DNA fractures increased after treatment with boric acid.Conclusion: In conclusion, the findings of this study have shown that boric acid can be used as a potential anticancer agent in medullary thyroid cancer and other cancers caused by similar mechanisms.

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“…Improved understanding of the physiopathology of osteoporosis has led to the development of pharmacological treatments targeting BMD, bone turnover and fractures. Lifestyle, nutrition and physical exercise are other parameters pertinent to prevent osteoporosis [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Does Physical Exercise Always Improve Bone Quality in Rats?

Portier

Benaîtreau

Pallu

2020

Life

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For decades, the osteogenic effect from different physical activities on bone in rodents remained uncertain. This literature review presents for the first time the effects on five exercise models (treadmill running, wheel running, swimming, resistance training and vibration modes) in three different experimental rat groups (males, females, osteopenic) on bone quality. The bone parameters presented are bone mineral density, micro-architectural and mechanical properties, and osteoblast/osteocyte and osteoclast parameters. This review shows that physical activities have a positive effect (65% of the results) on bone status, but we clearly observed a difference amongst the different protocols. Even if treadmill running is the most used protocol, the resistance training constitutes the first exercise model in term of osteogenic effects (87% of the whole results obtained on this model). The less osteogenic model is the vibration mode procedure (31%). It clearly appears that the gender plays a role on the bone response to swimming and wheel running exercises. Besides, we did not observe negative results in the osteopenic population with impact training, wheel running and vibration activities. Moreover, about osteoblast/osteocyte parameters, we conclude that high impact and resistance exercise (such jumps and tower climbing) seems to increase bone formation more than running or aerobic exercise. Among the different protocols, literature has shown that the treadmill running procedure mainly induces osteogenic effects on the viability of the osteocyte lineage in both males and females or ovariectomized rats; running in voluntary wheels contributes to a negative effect on bone metabolism in older male models; whole-body vertical vibration is not an osteogenic exercise in female and ovariectomized rats; whereas swimming provides controversial results in female models. For osteoclast parameters only, running in a voluntary wheel for old males, the treadmill running program at high intensity in ovariectomized rats, and the swimming program in a specific ovariectomy condition have detrimental consequences.

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Nutrition as prevention and treatment of osteoporosis

Cited by 38 publications

References 3 publications

Soilless biofortification, bioaccessibility, and bioavailability: Signposts on the path to personalized nutrition

Soilless biofortification, bioaccessibility, and bioavailability: Signposts on the path to personalized nutrition

Effects of Boric Acid on Invasion, Migration, Proliferation, Apoptosis, Cell Cycle and miRNAs in Medullary Thyroid Cancer Cells

Does Physical Exercise Always Improve Bone Quality in Rats?

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