Nutrition Antioxidant Status and Oxidative Stress in Professional Basketball Players: Effects of a Three Compound Antioxidative Supplement

Schröder, H.; Navarro, Estanis; Tramullas, Antonio; Mora, José Luis Cordero; Galiano, Delfín

doi:10.1055/s-2000-8870

Cited by 60 publications

(50 citation statements)

References 25 publications

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“…No change in OSAA was recorded in our study (Table 2). This is in accord with other studies of the antioxidant capacity after severe exercise (46,52). By contrast, some other reports have demonstrated an unexpected increase in the antioxidant capacity of athletes after exercise (23,48,53).…”

Section: Figsupporting

confidence: 34%

“…inhibits the propagation of lipid-peroxidation chain reactions in cellular membranes (42) and helps to regenerate vitamin E from the ␣-tocopheryl radical (43,44). It was therefore anticipated that the AA level would decline during and after the marches, as was reported in some studies (45,46). However, the plasma AA did not change from the start to the end of each march.…”

Section: Figmentioning

confidence: 87%

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Plasma antioxidant status and cell injury after severe physical exercise

Chevion

Moran

Heled

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

220

137

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Strenuous exercise leads to an increase in metabolic rate, increased production of reactive oxygen species, and compromised antioxidant defense systems. To study the effects of oxidative stress during strenuous exercise, a homogeneous group of 31 male subjects participated in a 6-month, 5 days͞week training schedule involving two extreme marches of 50 km and 80 km at sea level, separated by 2 weeks of regular training. Each participant carried 35 kg of extra weight. Blood samples were drawn imediately before and after each march. Twenty-nine subjects completed the 50-km march, and only 16 completed the 80-km march. Plasma levels of reduced ascorbic acid, total ascorbate, and dehydroascorbate did not undergo significant changes during either march. However, the 50-and 80-km marches led to 25% and 37% increases, respectively, in plasma levels of uric acid; due presumably to increases in the metabolic rate and consequent pyrimidine nucleotide metabolism. Both marches led to Ϸ10-fold increase leakage of creatine phosphokinase into the plasma. Likewise, plasma levels of aspartate transaminase, a characteristic marker of liver injury, increased Ϸ4-fold. Plasma levels of bilirubin, creatine, urea, and glucose also increased. Plasma protein carbonyl content, a marker of protein oxidative damage, decreased significantly during each march. These results are discussed with respect to the consideration that elevation of the respiration rate during exercise leads to production of more reactive oxygen species than the antioxidant systems can scavenge. Plausible explanations for leakage of molecules into the plasma are discussed.

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Section: Figsupporting

confidence: 34%

Section: Figmentioning

confidence: 87%

Plasma antioxidant status and cell injury after severe physical exercise

Chevion

Moran

Heled

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

220

137

View full text Add to dashboard Cite

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“…We recently reported in highly trained runners a decrease in antioxidant parameters after repetition of oxidative stimuli (intense hypoxic exercises) during 6 weeks (Pialoux et al, 2006). In this context, an antioxidant supplementation during intense training could maintain physiological antioxidant values and limit ROS damages induced by physical exercise (Schroder et al, 2000;Goldfarb et al, 2005;Morillas-Ruiz et al, 2006). However, the efficiency of antioxidant on the cellular protection against ROS has not yet been fully established.…”

Section: Discussionmentioning

confidence: 99%

Effects of the ‘live high–train low’ method on prooxidant/antioxidant balance on elite athletes

Pialoux¹,

Mounier²,

Rock

et al. 2008

Eur J Clin Nutr

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Background/Objectives: We previously demonstrated that acute exposure to hypoxia (3 h at 3000 m) increased oxidative stress markers. Thus, by using the 'living high-training low' (LHTL) method, we further hypothesized that intermittent hypoxia associated with endurance training alters the prooxidant/antioxidant balance. Subjects/Methods: Twelve elite athletes from the Athletic French Federation were subjected to 18-day endurance training. They were divided into two groups: one group (control group) trained at 1200 m and lived in hypoxia (2500-3000 m simulated altitude) and the second group trained and lived at 1200 m. The subjects performed an acute hypoxic test (10 min at 4800 m) before and immediately after the training. Plasma levels of advanced oxidation protein products (AOPP), malondialdehydes (MDA), ferric-reducing antioxidant power (FRAP), lipid-soluble antioxidants normalized for triacylglycerols, and cholesterol and retinol were measured before and after the 4800 m tests. Results: After the training, MDA and AOPP concentrations were decreased in response to the 4800 m test only for the control group. Eighteen days of LHTL induced a significant decrease of all antioxidant markers (FRAP, P ¼ 0.01; a-tocopherol, P ¼ 0.04; b-carotene, P ¼ 0.01 and lycopene, P ¼ 0.02) for the runners. This imbalance between antioxidant and prooxidant might result from insufficient intakes in vitamins A and E. Conclusions: The LHTL model characterized by the association of aerobic exercises and intermittent resting hypoxia exposures decreased the antioxidant status whereas the normoxic endurance training induced preconditioning mechanisms in response to the 4800 m test.

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“…The optimal bioavailability of vitamin C is shown to be reached with an intake of 200 mg/d (6) . As a consequence, any supplement above this threshold of intake has no effect on vitamin C plasma concentrations (5,10,11) . Even though there is a high nutritional density in vitamin C intakes as observed amongst highly trained athletes, paradoxically these athletes are high consumers of supplements.…”

Section: Does Physical Exercise Modify the Status Of Antioxidant Vitamentioning

confidence: 99%

Does physical exercise modify antioxidant requirements?

Margaritis

Rousseau

2008

Nutr. Res. Rev.

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Physical training is known to induce a biochemical adaptive response which might require an increase in the ingestion and/or the absorption of micronutrients. A question that is still being raised is whether acute or chronic exercise modifies antioxidant requirements. First, the present review brings to light the most crucial studies on the topic. Second, it interprets the established relationships between antioxidant micronutrient intakes and the adaptive response of antioxidant systems. Finally, it exposes the major questions connected with antioxidant micronutrient requirements for athletes. To this effect, the training-load interaction with nutrition is taken into account. As oxidative stress cannot be avoided, the imbalance between oxidants and antioxidants can be alleviated to minimise oxidative damage and outcomes. There is growing evidence that one specific antioxidant cannot by itself prevent oxidative stress-induced damage, as direct adverse effects of supplementation are attributed to undesirable synergic effects. Other effects can be supposed that limit the endogenous adaptive effect of training. High doses of antioxidant supplements can minimise the effects of radical oxygen species themselves or generate pro-oxidant effects. Effects are only exhibited when nutritional status is deficient. There are no convincing effects of supplementation in well-trained athletes. Risk/benefit analysis emerges on evidence for an unknown risk of supranutritional intakes, a supposed impairment of adaptive effects and a still unknown long-term risk. Appropriate status can be achieved by a diversified and balanced diet, adapted to specific needs, by awareness of high-density food intakes (avoiding products containing a low density of micronutrients).

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Nutrition Antioxidant Status and Oxidative Stress in Professional Basketball Players: Effects of a Three Compound Antioxidative Supplement

Cited by 60 publications

References 25 publications

Plasma antioxidant status and cell injury after severe physical exercise

Plasma antioxidant status and cell injury after severe physical exercise

Effects of the ‘live high–train low’ method on prooxidant/antioxidant balance on elite athletes

Does physical exercise modify antioxidant requirements?

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