Nutrition and the immune system

Klasing, Kirk C.

doi:10.1080/00071660701671336

Cited by 278 publications

(212 citation statements)

References 101 publications

Supporting

Mentioning

184

Contrasting

Unclassified

Order By: Relevance

“…Nestes casos a resposta do organismo é a produção aumentada de células e proteínas, como as proteínas de fase aguda sintetizadas pelo fígado (Klasing 2007) e consequente piora no desempenho zootécnico. Este aumento na produção de células como resposta imunológica resulta em redistribuição e maior gasto de nutrientes como lisina.…”

Section: Discussionunclassified

Avaliação da resposta imunológica da mucosa intestinal de frangos de corte desafiados com diferentes sorovares de Salmonella

et al. 2015

View full text Add to dashboard Cite

RESUMO.-Objetivou-se com o presente estudo comparar o efeito de diferentes sorovares de Salmonella na resposta imune local da mucosa do intestino de frangos de corte. Aos sete dias de idade, as aves foram desafiadas com os sorovares S. Enteritidis, S. Typhimurium, S. Senftenberg, S. Mbandaka e S. Minnesota. Foi observado que todos os sorovares testados foram capazes de colonizar o intestino das aves sendo possível o isolamento de Salmonella em suabes de cloaca, 48 h após inoculação. De maneira geral, as aves do grupo controle negativo, que não foram desafiados apresentaram quantidade significativamente menor de células imunológicas na mucosa intestinal do que as aves desafiadas. Porém, verificou--se que os sorovares de Salmonella, utilizados neste estudo, apresentaram diferentes efeitos sobre a dinâmica celular da mucosa do íleo e ceco e afetaram de modo diferente o ganho de peso e ganho médio diário das aves demonstrando distintos graus de patogenicidade. Os sorovares Enteritidis e Typhimurium apresentaram um efeito mais intenso tanto no desempenho quanto na mobilização de células imunoló-gicas na mucosa intestinal de frangos de corte. The study was designed to compare the effect of different Salmonella serovars in immune response across the count of CD8+ cells, CD4+ cells, goblet cells and macrophages in the gut mucosa of broilers. During the experimental inoculation at 7 day-old were used Salmonella enterica subspecies enterica sorovars Enteritidis, Typhimurium, Senftenberg, Mbandaka and Minnesota. It was observed that all serovars tested were capable of contaminating the poultry being possible counts of Salmonella in cloacal swabs, 48 h after inoculation and into the crop and cecum, at 14 and 20 day-old. Serovars tested had different effects on broiler performance assessed at 20 days. In the mucosa of the ileum and cecum of broilers, it was observed that some of the serotypes increased CD8 + cells, CD4 + cells, goblet cells and macrophages compared to the negative control group both at 14 and at 20 day-old. S. Enteritidis and S. Typhimurium are the serovars that showed the more intense effect in live performance and in the immune system of birds showing pathogenic characteristic; generally the broilers of the negative control showed significantly less immune cells on the intestinal mucosa than broilers inoculated experimentally. However, it was found that the Salmonella serovars used in this study had different effects on the cellular dynamics of the mucosa of the ileum and cecum and differently affect weight gain and average daily gain of poultry showing different levels of pathogenicity. Avaliação da resposta imunológica da mucosa intestinal

show abstract

Section: Discussionunclassified

Avaliação da resposta imunológica da mucosa intestinal de frangos de corte desafiados com diferentes sorovares de Salmonella

et al. 2015

View full text Add to dashboard Cite

show abstract

“…First, immune function is affected by host nutrition, which may greatly affect the outcome of infection (Lazzaro and Little, 2009;Schmid-Hempel, 2011). Host nutrition influences both constitutive and inducible immune function, with consequences for morbidity and mortality (Cunningham-Rundles et al, 2005;Klasing, 2007) (Adams and Hewison, 2008;Amar et al, 2007;Calder, 2006;Cohen et al, 2008;Kelley and Bendich, 1996;Klasing, 2007;Kolb, 1997;Kristan, 2007;Samartin and Chandra, 2000;Sorci and Faivre, 2009). Second, nutrition-based interactions are one of the major sources of microbial benefits to animals (Bäckhed et al, 2005;Douglas, 2010;Hooper et al, 2002;Kau et al, 2011;Topping and Clifton, 2001).…”

Section: Introductionmentioning

confidence: 99%

Integrating nutrition and immunology: A new frontier

Ponton

Wilson

Holmes

et al. 2013

Journal of Insect Physiology

129

View full text Add to dashboard Cite

“…Several studies have shown that estimates for protein and energy requirements for immune processes in animals can be empirically derived (Lochmiller and Deerenberg, 2000;Houdijk et al, 2001;Klasing, 2007). The model of Romanyukha et al (2006) illustrates that empirical estimation of resource requirements for specific immune processes is feasible and can lead to valuable model predictions: after deriving estimates of energy requirements for eight different immune processes relevant in pneumonia infections, their mathematical model could predict whether pneumonia infections will lead to acute or chronic conditions based on energy costs alone.…”

Section: Category 2: Models That Consider the Impact Of Infection On mentioning

confidence: 99%

The role of mathematical models of host–pathogen interactions for livestock health and production – a review

Doeschl‐Wilson

2011

Animal

View full text Add to dashboard Cite

Compared with the application of mathematical models to study human diseases, models that describe animal responses to pathogen challenges are relatively rare. The aim of this review is to explain and show the role of mathematical host-pathogen interaction models in providing underpinning knowledge for improving animal health and sustaining livestock production. Existing host-pathogen interaction models can be assigned to one of three categories: (i) models of the infection and immune system dynamics, (ii) models that describe the impact of pathogen challenge on health, survival and production and (iii) models that consider the co-evolution of host and pathogen. State-of-the-art approaches are presented and discussed for models belonging to the first two categories only, as they concentrate on the host-pathogen dynamics within individuals. Models of the third category fall more into the class of epidemiological models, which deserve a review by themselves. An extensive review of published models reveals a rich spectrum of methodologies and approaches adopted in different modelling studies, and a strong discrepancy between models concerning diseases in animals and models aimed at tackling diseases in humans (most of which belong to the first category), with the latter being generally more sophisticated. The importance of accounting for the impact of infection not only on health but also on production poses a considerable challenge to the study of host-pathogen interactions in livestock. This has led to relatively simplistic representations of host-pathogen interaction in existing models for livestock diseases. Although these have proven appropriate for investigating hypotheses concerning the relationships between health and production traits, they do not provide predictions of an animal's response to pathogen challenge of sufficient accuracy that would be required for the design of appropriate disease control strategies. A synthesis between the modelling methodologies adopted in categories 1 and 2 would therefore be desirable. The progress achieved in mathematical modelling to study immunological processes relevant to human diseases, together with the current advances in the generation and analysis of biological data related to animal diseases, offers a great opportunity to develop a new generation of host-pathogen interaction models that take on a fundamental role in the study and control of disease in livestock.

show abstract

Nutrition and the immune system

Cited by 278 publications

References 101 publications

Avaliação da resposta imunológica da mucosa intestinal de frangos de corte desafiados com diferentes sorovares de Salmonella

Avaliação da resposta imunológica da mucosa intestinal de frangos de corte desafiados com diferentes sorovares de Salmonella

Integrating nutrition and immunology: A new frontier

The role of mathematical models of host–pathogen interactions for livestock health and production – a review

Contact Info

Product

Resources

About