Nutrition and the Clock Gene

Figueroa, Ana Lucia C.

doi:10.4183/aeb.2015.489

Cited by 2 publications

(1 citation statement)

References 35 publications

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“…The food ingestion and absorption of nutrients is correlated with the endogenous clock -with circadian secretion of hormones and different metabolic processes during daylight and night time. This new concept supports the role of the circadian clock in the development of metabolic diseases (81).…”

Section: Other Factorssupporting

confidence: 72%

Updating the Concept of Metabolically Healthy Obesity

Bala

Hâncu

2016

Acta Endo (Buc)

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Obesity is a well-recognized risk factor for type 2 diabetes, cardiovascular disease, and several types of cancer. However, a proportion of the obese individuals display a significantly lower risk for metabolic complications than expected for their degree of body mass index, and this subtype of obesity was described as "metabolically healthy obesity" (MHO). No universally accepted criteria for the diagnosis of MHO exists and the prevalence of this subtype of obesity varies largely according to criteria used. Broadly, MHO is characterized by a lower amount of visceral fat, a more favorable inflammatory profile, and less insulin resistance as compared to the metabolically unhealthy obesity. Currently, controversies exist regarding the risk of cardiovascular events and all-cause mortality associated with MHO as compared to metabolically-healthy non-obese individuals. Further research is needed in order to identify the MHO phenotype and if MHO is truly healthy for a long period of time or if it is a transient state from normal metabolic/normal weight to abnormal metabolic/obese state. This review will discuss the MHO definition criteria; the differences between MHO and metabolically unhealthy obesity; the possible underlying mechanisms and clinical implications of MHO.

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Section: Other Factorssupporting

confidence: 72%

Updating the Concept of Metabolically Healthy Obesity

Bala

Hâncu

2016

Acta Endo (Buc)

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Oxidative Priority, Meal Frequency, and the Energy Economy of Food and Activity: Implications for Longevity, Obesity, and Cardiometabolic Disease

Cronise

Sinclair

Bremer

2017

Metabolic Syndrome and Related Disorders

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In most modern societies, the relationship that many individuals have with food has fundamentally changed from previous generations. People have shifted away from viewing food as primarily sustenance, and rather now seek out foods based on pure palatability or specific nutrition. However, it is far from clear what optimal nutrition is for the general population or specific individuals. We previously described the Food Triangle as a way to organize food based on an increasing energy density paradigm, and now expand on this model to predict the impact of oxidative priority and both nutrient and fiber density in relation to caloric load. When combined with meal frequency, integrated energy expenditure, macronutrient oxidative priority, and fuel partitioning expressed by the respiratory quotient, our model also offers a novel explanation for chronic overnutrition and the cause of excess body fat accumulation. Herein, we not only review how metabolism is a dynamic process subject to many regulators that mediate the fate of ingested calories but also discuss how the Food Triangle predicts the oxidative priority of ingested foods and provides a conceptual paradigm for healthy eating supported by health and longevity research.

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Nutrition and the Clock Gene

Cited by 2 publications

References 35 publications

Updating the Concept of Metabolically Healthy Obesity

Updating the Concept of Metabolically Healthy Obesity

Oxidative Priority, Meal Frequency, and the Energy Economy of Food and Activity: Implications for Longevity, Obesity, and Cardiometabolic Disease

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