Nutrition and neuroendocrine tumors: An update of the literature

Altieri, Barbara; Barrea, Luigi; Modica, Roberta; Muscogiuri, Giovanna; Savastano, Silvia; Colao, Annamaria; Faggiano, Antongiulio

doi:10.1007/s11154-018-9466-z

Cited by 40 publications

(40 citation statements)

References 77 publications

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“…Nevertheless, surgical treatment can influence nutritional status, causing diarrhea for several reasons. As previously discussed, the extent of the intestinal resection and the anatomical position of the resected region are the main factors with an impact on bowel transit time, vitamin B12 action, bile acid secretion, fat-soluble vitamins absorption and digestion [19,67,70].…”

Section: Therapiesmentioning

confidence: 99%

“…Nutritional status in GEP-NET patients is deeply affected by the excessive production of gastrointestinal hormones, peptides, and amines, which could cause malabsorption, diarrhea, steatorrhea, and altered gastrointestinal motility. Furthermore, surgical resection of GEP-NET could change the anatomy of the gastrointestinal tract, and therapy with somatostatin analogs (SSAs) could modify the function of the gastrointestinal tract by inhibiting the secretion of pancreatic enzymes and hormones, impairing normal absorptive function (Figure 1) [19,67]. It has been recently demonstrated that GEP-NET patients have a dietary pattern with significantly lower adherence to the Mediterranean diet compared to a health-matched control group, less frequently consuming vegetables, fruits, wine, fish/seafood, and nuts, and more frequently red/processed meats, butter, cream, margarine, and soda drinks [20].…”

Section: Nutritional Statusmentioning

confidence: 99%

“…Thus, similarly to surgical treatment, a direct relationship between SSA treatment and bone has not been demonstrated. It could be possible that malabsorption of fat and fat-soluble vitamins may lead to reduced bone density due to vitamin D deficiency [19]. Nevertheless, this hypothesis has been contradicted.…”

Section: Therapiesmentioning

confidence: 99%

“…It has been demonstrated that NET patients have a greater clinical burden of disease than matched control subjects, with increased risk of cardiovascular, hepatic, and gastrointestinal diseases, as well as osteopenia and osteoporosis [18]. Moreover, the tumor itself and the systemic therapy may have an impact on patients' nutritional status [19,20], leading to a deficiency of different vitamins, including vitamin D [21,22]. It is well demonstrated that vitamin D plays a key role in the process of bone formation [23].…”

Section: Introductionmentioning

confidence: 99%

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Bone Metabolism and Vitamin D Implication in Gastroenteropancreatic Neuroendocrine Tumors

Altieri¹,

Dato

Modica

et al. 2020

Nutrients

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Patients affected by gastroenteropancreatic–neuroendocrine tumors (GEP–NETs) have an increased risk of developing osteopenia and osteoporosis, as several factors impact on bone metabolism in these patients. In fact, besides the direct effect of bone metastasis, bone health can be affected by hormone hypersecretion (including serotonin, cortisol, and parathyroid hormone-related protein), specific microRNAs, nutritional status (which in turn could be affected by medical and surgical treatments), and vitamin D deficiency. In patients with multiple endocrine neoplasia type 1 (MEN1), a hereditary syndrome associated with NET occurrence, bone damage may carry other consequences. Osteoporosis may negatively impact on the quality of life of these patients and can increment the cost of medical care since these patients usually live with their disease for a long time. However, recommendations suggesting screening to assess bone health in GEP–NET patients are missing. The aim of this review is to critically analyze evidence on the mechanisms that could have a potential impact on bone health in patients affected by GEP–NET, focusing on vitamin D and its role in GEP–NET, as well as on factors associated with MEN1 that could have an impact on bone homeostasis.

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Section: Therapiesmentioning

confidence: 99%

Section: Nutritional Statusmentioning

confidence: 99%

Section: Therapiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Bone Metabolism and Vitamin D Implication in Gastroenteropancreatic Neuroendocrine Tumors

Altieri¹,

Dato

Modica

et al. 2020

Nutrients

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show abstract

“…If the decision is made to perform surgery on a patient with NEN, a multidisciplinary team should discuss the perioperative proceedings including an effective prophylaxis against an intraoperative carcinoid crisis, supportive therapy, and nutrition [7,8,22]. Psychosocial support, expert nursing, nutritional support and management of cancer related pain will be reviewed by the groups, Auernhammer and Spitzweg, as well as the group, Faggiano, Colao, Muscogiuri and colleagues [23,24].…”

mentioning

confidence: 99%