Nutrition and Metabolic Bone Disease in Old Age

Exton‐Smith, A. N.; Hodkinson, H. M.; Stanton, Brielle

doi:10.1016/s0140-6736(66)92927-8

Cited by 75 publications

(17 citation statements)

References 6 publications

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“…For example in a study of 39 elderly women, 25% had an intake of less than 50 IU daily and only 33% received more than 100 1U daily (4). Comparison of vitamin D intakes between those who have osteomalacia with apparently normal controls has shown, as in this study, that very low intakes of vitamin D are found in people who do not have osteomalacia.…”

Section: Discussionsupporting

confidence: 54%

Role of Nutrition in the Development of Osteomalacia in the Elderly

Pittet

Davie

Lawson³

1979

Ann Nutr Metab

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A dietary survey has been carried out of elderly people with osteomalacia. The commonest type of osteomalacia was that associated with partial gastrectomy. Although a dietary deficiency of vitamin D has been suggested as a cause of the osteomalacia the intake of this substance was not significantly different from that in controls to explain the development of the disease. It was found, however, that patients with osteomalacia went outside much less than controls and given the contribution of sunlight to meeting vitamin D requirements it is suggested that further consideration should be given to this factor in the aetiology of post-gastrectomy osteomalacia.

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Section: Discussionsupporting

confidence: 54%

Role of Nutrition in the Development of Osteomalacia in the Elderly

Pittet

Davie

Lawson³

1979

Ann Nutr Metab

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“…However, Hunt et al (12) reported vitamin D intake closely correlated to serum 25(OH)D3. Correlations of dietary vitamin D were also reported with plasma calcium (23) and with the calcium-phosphorus product (6,18). In the population studied by us serum calcium level was positively correlated with reported vitamin D intake.…”

Section: Discussionmentioning

confidence: 55%

“…It has also been suggested (1) that osteomalacia in the elderly contributes much to the steep rise in incidence of femoral-neck fractures with advancing age. The main causes of osteomalacia in the elderly are a diet deficient in vitamin D (4,6,19) and lack of sunshine (4,11,19). Sometimes, osteomalacia is secondary to diseases of the alimentary tract which interfere with absorption (4).…”

mentioning

confidence: 99%

Biochemical Parameters of Vitamin D Nutriture in Old People in Jerusalem

et al. 1979

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Serum 25-hydroxycholecalciferol (25[OH]D₃) levels and other parameters of vitamin D nutriture were examined in 58 subjects aged 70 or more, living in Jerusalem. They were compared with those of 54 young adults living in the same neighbourhood. No evidence was obtained of a lower level of vitamin D nutriture in the elderly compared to younger adults. Serum 25(OH)D₃ of the elderly adults was 18.4 (SEM: 1.4) ng/ml and in the younger adults, 17.8 (1.0) ng/ml. There was no seasonal variation in serum 25(OH)D₃, nor could a strong association be found between reported vitamin D intake nor with exposure to sunshine. There was a negative correlation between serum alkaline phosphatase and the calcium-phosphorus product in serum. High values of alkaline phosphatase were associated with reported low exposure to sunlight and, in elderly persons, with a reported low consumption of vitamin D.

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“…Although osteopenia in the elderly is mainly due to osteoporosis, a significant number of patients suffering from hip fractures have occult osteomalacia (1)(2)(3)(4)(5). In the United Kingdom, several investigators have demonstrated, by histologic evaluation of bone biopsies, that 20-30% of women and up to 40% of men with fractures of the proximal aspect of the femur have occult osteomalacia (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Aging Decreases the Capacity of Human Skin to Produce Vitamin D₃

MacLaughlin

Holick

Kasper³

1986

Nut in Clin Prac

322

350

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An evaluation of surgically obtained skin (age range, 8-92 yr) revealed that there is an age-dependent decrease in the epidermal concentrations of provitamin D3 (7-dehydrocholesterol). To ascertain that aging indeed decreased the capacity of human skin to produce vitamin D3, some of the skin samples were exposed to ultraviolet radiation and the content of previtamin D3 was determined in the epidermis and dermis. The epidermis in the young and older subjects was the major site for the formation of previtamin D3, accounting for >80% of the total previtamin D3 that was produced in the skin. A comparison of the amount of previtamin D3 produced in the skin from the 8-and 18-yr-old subjects with the amount produced in the skin from the 77-and 82-yr-old subjects revealed that aging can decrease by greater than twofold the capacity of the skin to produce previtamin D3. Recognition of this difference may be extremely important for the elderly, who infrequently expose a small area of skin to sunlight and who depend on this exposure for their vitamin D nutritional needs.

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Nutrition and Metabolic Bone Disease in Old Age

Cited by 75 publications

References 6 publications

Role of Nutrition in the Development of Osteomalacia in the Elderly

Role of Nutrition in the Development of Osteomalacia in the Elderly

Biochemical Parameters of Vitamin D Nutriture in Old People in Jerusalem

Aging Decreases the Capacity of Human Skin to Produce Vitamin D₃

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Nutrition and Metabolic Bone Disease in Old Age

Cited by 75 publications

References 6 publications

Role of Nutrition in the Development of Osteomalacia in the Elderly

Role of Nutrition in the Development of Osteomalacia in the Elderly

Biochemical Parameters of Vitamin D Nutriture in Old People in Jerusalem

Aging Decreases the Capacity of Human Skin to Produce Vitamin D3

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Aging Decreases the Capacity of Human Skin to Produce Vitamin D₃