Nutrition and immune system: from the Mediterranean diet to dietary supplementary through the microbiota

Barrea, Luigi; Muscogiuri, Giovanna; Frías-Toral, Evelyn; Laudisio, Daniela; Pugliese, Gabriella; Castellucci, Bianca; Garcia-Velasquez, Eloisa; Savastano, Silvia; Colao, Annamaria

doi:10.1080/10408398.2020.1792826

Cited by 114 publications

(82 citation statements)

References 251 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This diet is characterized by a combination of highly complex carbohydrates in fiber (found in cereals, legumes, vegetables, fruits), polyunsaturated fatty acids with antiatherogenic and anti-inflammatory properties (found in olive oil and nuts), and bioactive compounds with antioxidative properties such as flavonoids, phytosterols, terpenes and polyphenols [ 185 ]. Similarly, a perfect balance of micronutrients, which are abundant in this diet, including vitamins and minerals, help avoid malnutrition and immunodeficiencies [ 186 , 187 ]. The immune system needs to cooperate with a group of substances to correctly perform its functions, and some of them are required in higher concentrations depending on the health status and the patient [ 188 ].…”

Section: Mediterranean Diet As a Model Of Healthy Eatingmentioning

confidence: 99%

Nutritional Components in Western Diet Versus Mediterranean Diet at the Gut Microbiota–Immune System Interplay. Implications for Health and Disease

et al. 2021

View full text Add to dashboard Cite

The most prevalent diseases of our time, non-communicable diseases (NCDs) (including obesity, type 2 diabetes, cardiovascular diseases and some types of cancer) are rising worldwide. All of them share the condition of an “inflammatory disorder”, with impaired immune functions frequently caused or accompanied by alterations in gut microbiota. These multifactorial maladies also have in common malnutrition related to physiopathology. In this context, diet is the greatest modulator of immune system–microbiota crosstalk, and much interest, and new challenges, are arising in the area of precision nutrition as a way towards treatment and prevention. It is a fact that the westernized diet (WD) is partly responsible for the increased prevalence of NCDs, negatively affecting both gut microbiota and the immune system. Conversely, other nutritional approaches, such as Mediterranean diet (MD), positively influence immune system and gut microbiota, and is proposed not only as a potential tool in the clinical management of different disease conditions, but also for prevention and health promotion globally. Thus, the purpose of this review is to determine the regulatory role of nutritional components of WD and MD in the gut microbiota and immune system interplay, in order to understand, and create awareness of, the influence of diet over both key components.

show abstract

Section: Mediterranean Diet As a Model Of Healthy Eatingmentioning

confidence: 99%

Nutritional Components in Western Diet Versus Mediterranean Diet at the Gut Microbiota–Immune System Interplay. Implications for Health and Disease

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The increase in mortality for individuals returning low nitrogen values may be due to an inadequate dietary intake or a diet based on low protein sources. Many studies, in fact, emphasize that suboptimal nutrition may eventually alter the correct functioning of the individual’s immune system [ 6 , 108 , 109 , 110 , 111 ]. Adequate diet and suitable levels of micronutrients are important for controlling inflammations and oxidative stress as well as for maintaining the levels of antibody production and, more in general, for the correct functioning of the immune response [ 109 , 112 ].…”

Section: Discussionmentioning

confidence: 99%

How Does Diet Influence Our Lives? Evaluating the Relationship between Isotopic Signatures and Mortality Patterns in Italian Roman Imperial and Medieval Periods

et al. 2021

View full text Add to dashboard Cite

The present research investigates the relationship between dietary habits and mortality patterns in the Roman Imperial and Medieval periods. The reconstructions of population dynamics and subsistence strategies provide a fascinating source of information for understanding our history. This is particularly true given that the changes in social, economic, political, and religious aspects related to the transition from the Roman period to the Middle Ages have been widely discussed. We analyzed the isotopic and mortality patterns of 616 individuals from 18 archeological sites (the Medieval Latium sites of Colonna, Santa Severa, Allumiere, Cencelle, and 14 Medieval and Imperial funerary contexts from Rome) to compile a survivorship analysis. A semi-parametric approach was applied, suggesting variations in mortality patterns between sexes in the Roman period. Nitrogen isotopic signatures influenced mortality in both periods, showing a quadratic and a linear effect for Roman Imperial and Medieval populations, respectively. No influence of carbon isotopic signatures has been detected for Roman Imperial populations. Conversely, increased mortality risk for rising carbon isotopic values was observed in Medieval samples.

show abstract

“…This connection is essential when considering obesity-related diseases. Low VITD levels and severe obesity are significantly associated with some cardio-metabolic risk factors, including high body mass index, waist circumference, blood pressure, impaired lipid and glycaemic profile, and insulin resistance, as they seem associated with worse cardiovascular outcomes and higher cancer incidence and mortality [13]. Most of the immune cells, such as macrophages, T and B lymphocytes, neutrophils and dendritic cells express VDR.…”

Section: Extra-skeletal Effects Of Vitamin Dmentioning

confidence: 99%

Vitamin D in the Covid-19 era: a review with recommendations from a G.I.O.S.E.G. expert panel

et al. 2021

Self Cite

View full text Add to dashboard Cite

Vitamin D (VITD) is a key hormone for bone health and has relevant extra-skeletal effects that might play a role in the prevention and treatment of COronaVIrus Disease 19 . Literature regarding this scenario is voluminous but controversial. Glucocorticoid Induced Osteoporosis Skeletal Endocrinology Group (G.I.O.S.E.G) has been present in the scientific debate about the use of VITD and has regularly interfaced national regulatory agencies to ensure appropriateness of its employment. Given the current pandemic and the questions on COVID-19 and VITD, G.I.O.S.E.G. appointed an expert panel to advise how to consider this issue best. The results of these deliberations are reported in the current recommendation paper.

show abstract

Nutrition and immune system: from the Mediterranean diet to dietary supplementary through the microbiota

Cited by 114 publications

References 251 publications

Nutritional Components in Western Diet Versus Mediterranean Diet at the Gut Microbiota–Immune System Interplay. Implications for Health and Disease

Nutritional Components in Western Diet Versus Mediterranean Diet at the Gut Microbiota–Immune System Interplay. Implications for Health and Disease

How Does Diet Influence Our Lives? Evaluating the Relationship between Isotopic Signatures and Mortality Patterns in Italian Roman Imperial and Medieval Periods

Vitamin D in the Covid-19 era: a review with recommendations from a G.I.O.S.E.G. expert panel

Contact Info

Product

Resources

About