Nutrition and HIV Infection: Review of Weight Loss and Wasting in the Era of Highly Active Antiretroviral Therapy from the Nutrition for Healthy Living Cohort

Mangili, Alexandra; Murman, David H.; Zampini, Anna; Wanke, Christine; Mayer, Kenneth H.

doi:10.1086/500398

Cited by 200 publications

(202 citation statements)

References 29 publications

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“…The results suggest that weight loss in HIV-infected adults is not essentially a loss of lean body mass (LBM), but is an intricate interaction of lean body and fat mass, depending on baseline body weight and composition. 5,[25][26][27] In the current study, a significant correlation was found between the MUAC and the CD4 cell count. It is suggested that weight loss should concern fat mass whereas at a more advanced stage of immunosuppression, lean mass could be affected.…”

Section: Discussionmentioning

confidence: 77%

Nutritional status, quality of life and CD4 cell count of adults living with HIV/AIDS in the Ga-Rankuwa area (South Africa)

Venter

Gericke

Bekker

2009

South African Journal of Clinical Nutrition

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Section: Discussionmentioning

confidence: 77%

Nutritional status, quality of life and CD4 cell count of adults living with HIV/AIDS in the Ga-Rankuwa area (South Africa)

Venter

Gericke

Bekker

2009

South African Journal of Clinical Nutrition

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“…Nutritional status is an important predictor of progression to AIDS and survival of HIVinfected patients (Mangili et al, 2006;Melchior et al, 1999;Ott et al, 1995;Suttmann et al, 1995;Tang et al, 2002;Tang et al, 2005;van der Sande et al, 2004). Body mass index (BMI) is an important measure of nutritional status in HIV infected patients.…”

Section: Introductionmentioning

confidence: 99%

Drug use and other risk factors related to lower body mass index among HIV-infected individuals

Quach

Wanke

Schmid

et al. 2008

Drug and Alcohol Dependence

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Malnutrition is associated with morbidity and mortality in HIV infected individuals. Little research has been conducted to identify the roles that clinical, illicit drug use and socioeconomic characteristics play in the nutritional status of HIV-infected patients. This cross-sectional analysis included 562 HIV-infected participants enrolled in the Nutrition for Healthy Living study conducted in Boston, MA and Providence, RI. The relationship between body mass index (BMI) and several covariates (type of drug use, demographic, and clinical characteristics) were examined using linear regression.Overall, drug users had a lower BMI than non-drug users. The BMI of cocaine users was 1.4 kg/ m 2 less than that of patients who did not use any drugs, after adjusting for other covariates (p= 0.02). The BMI of participants who were over the age of 55 years was 2.0 kg/m 2 less than that of patients under the age of 35, and BMI increased by 0.3 kg/m 2 with each 100 cells/mm 3 increase in CD4 count. HAART use, adherence to HAART, energy intake, AIDS status, hepatitis B and hepatitis C co-infections, cigarette smoking and depression were not associated with BMI in the final model.In conclusion, BMI was lower in drug users than non-drug users, and was lowest in cocaine users. BMI was also directly associated with CD4 count and inversely related to age more than 55 years old. HIV infected cocaine users may be at higher risk of developing malnutrition, suggesting the need for anticipatory nutritional support.

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“…HIV or TB infection increases metabolic demands and is likely to be associated with significant weight loss, even if treated. 74 Finally, obesity is considered an inflammatory process and is increasingly common in both high-and low-resource settings. 47 As depicted in Fig 1, the environment of the pregnant woman also serves as the environment for the fetus.…”

Section: The Impact Of the Interaction Of Maternal Nutrition Inflammmentioning

confidence: 99%

Neurodevelopment: The Impact of Nutrition and Inflammation During Preconception and Pregnancy in Low-Resource Settings

et al. 2017

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The rapid pace of fetal development by far exceeds any other stage of the life span, and thus, environmental influences can profoundly alter the developmental course. Stress during the prenatal period, including malnutrition and inflammation, impact maternal and fetal neurodevelopment with long-term consequences for physical and mental health of both the mother and her child. One primary consequence of maternal malnutrition, inflammation, and other sources of prenatal stress is a poor birth outcome, such as prematurity or growth restriction. These phenotypes are often used as indications of prenatal adversity. In fact, the original evidence supporting the fetal programming hypothesis came from studies documenting an association between birth phenotype and the development of subsequent physical and mental health problems. Fetal growth restriction in both term and preterm infants is associated with neonatal morbidities and a wide variety of behavioral and psychological diagnoses in childhood and adolescence, including attention-deficit/hyperactivity disorder, anxiety, depression, internalizing and thought problems, poor social skills, and autism spectrum disorder. Improving maternal–child health requires interventions that begin before pregnancy and continue throughout gestation and into the postpartum period. Such interventions might include supporting pregnancy intention, maternal nutrition, health/medical care, mental health, and providing social support. This article discusses the impact of maternal nutrition and inflammation during preconception and pregnancy among women living in low-resource settings, with an emphasis on key knowledge gaps that need to be addressed to guide program and policy decisions at local, regional and global levels.

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Nutrition and HIV Infection: Review of Weight Loss and Wasting in the Era of Highly Active Antiretroviral Therapy from the Nutrition for Healthy Living Cohort

Cited by 200 publications

References 29 publications

Nutritional status, quality of life and CD4 cell count of adults living with HIV/AIDS in the Ga-Rankuwa area (South Africa)

Nutritional status, quality of life and CD4 cell count of adults living with HIV/AIDS in the Ga-Rankuwa area (South Africa)

Drug use and other risk factors related to lower body mass index among HIV-infected individuals

Neurodevelopment: The Impact of Nutrition and Inflammation During Preconception and Pregnancy in Low-Resource Settings

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