Nutrition and Depression: The Role of Folate

Alpert, Jonathan E.; Fava, Maurizio

doi:10.1111/j.1753-4887.1997.tb06468.x

Cited by 159 publications

(51 citation statements)

References 30 publications

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“…A recent finding also suggested that trans-unsaturated fatty acids have a dose-response effect on clinical depression (48) . Therefore, the intake of special nutrients is often considered a mediator of the association between whole diet and mental problems (49)(50)(51)(52) .…”

Section: Discussionmentioning

confidence: 99%

Is there any relationship between dietary patterns and depression and anxiety in Chinese adolescents?

Weng

Hao

Qing-wen

et al. 2011

Public Health Nutr.

163

123

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Objective: To determine the association between major dietary patterns characterized by factor analysis and risk of depression and anxiety symptoms among adolescents. Design: Diet and symptoms of depression and anxiety were assessed in a crosssectional survey among students attending junior high school. Dietary patterns were derived from a self-reported FFQ, which consisted of thirty-eight items. Anthropometric measurements were also performed. Setting: Four junior high schools in Bengbu city, China. Subjects: A random sample of 5003 adolescents, 11-16 years of age (mean 13?21 years). Results: Three major dietary patterns were identified in the study based on factor analysis: 'snack', 'animal food' and 'traditional'. The prevalence of depression symptoms, anxiety disorders and the coexistence of both were 11?2 % (560/5003), 14?6 % (732/5003) and 12?6 % (629/5003), respectively. After adjustment for potential confounders, adolescents in the highest tertile of snack dietary pattern scores had a higher odds for 'pure' psychological symptoms ('depression without anxiety', OR 5 1?64; 95 % CI 1?30, 2?06; and 'anxiety without depression', OR 5 1?87; 95 % CI 1?51, 2?31) compared with coexisting depression and anxiety (OR 5 1?93; 95 % CI 1?54, 2?43). Similar to snacks, high consumption of animal foods was associated with a higher risk of psychological symptoms. Compared with low consumption, adolescents in the highest tertile of traditional dietary pattern scores had lower odds for 'pure' depression (OR 5 0?38; 95 % CI 0?30, 0?49), 'pure' anxiety (OR 5 0?85; 95 % CI 0?69, 1?04) and coexisting anxiety and depression (OR 5 0?50; 95 % CI 0?39, 0?63).

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Section: Discussionmentioning

confidence: 99%

Is there any relationship between dietary patterns and depression and anxiety in Chinese adolescents?

Weng

Hao

Qing-wen

et al. 2011

Public Health Nutr.

163

123

View full text Add to dashboard Cite

show abstract

“…Tryptophan depletion can induce a relapse in depressive patients (154). Evidence supporting an association between folate deficiency and depressive symptoms was already reported in 1962 (155). One important step involving folate is the participation of tetra-hydro-biopterin (BH4) as a co-factor in the hydroxylation of phenylalanine and tryptophan, the precursors of dopamine, norepinefrine and serotonine.…”

Section: Neurotransmitter Synthesismentioning

confidence: 99%

The prevalence and risk factors for age-related macular degeneration in rural–urban India, Sankara Nethralaya Rural–Urban Age-related Macular degeneration study, Report No. 1

Raman

Pal

Ganesan

et al. 2016

Eye

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“…Folate deficiency is present in up to 50% of those with depression (Alpert and Fava 1997), and genetic variants associated with reduced folate metabolism result in inflammation and elevated homocysteine levels, which can reduce the concentrations of the neurotransmitters serotonin, norepinephrine, and dopamine (Bottiglieri 2000). Adjunctive L-methyl folate has recently been shown to be helpful in adults with treatmentresistant depression (Papakostas et al 2012).…”

Section: Folic Acid (Vitamin B9)mentioning

confidence: 99%

Nutritional and Safety Outcomes from an Open-Label Micronutrient Intervention for Pediatric Bipolar Spectrum Disorders

Frazier

Gracious²,

Arnold³

et al. 2013

Journal of Child and Adolescent Psychopharmacology

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Objective: The purpose of this study was to report the safety, tolerability, and serum micronutrient concentrations and their correlations with mood changes from an 8 week pilot feasibility study of a 36 ingredient multinutrient supplement, EMPowerplus (EMP+), for pediatric bipolar spectrum disorders (BPSD). Methods: Ten children ages 6-12 received EMP + escalating from one to four capsules t.i.d., with four children increased to the maximum suggested dose, five capsules t.i.d. Outcome measures were micronutrient concentrations in serum and red blood cells, vital signs, body mass index (BMI), dietary intake (Food Frequency Questionnaire and 24 hour dietary recall interview), and mood and global functioning ratings. Results: Seven children (70%) completed the study. Three (30%) terminated early for tolerability and compliance issues. Adverse effects were mild and transient, and chiefly consisted of initial insomnia or gastrointestinal (GI) upset. No differences occurred in BMI ( p = 0.310) or waist-hip ratio (WHR; p = 0.674) pre-to postsupplementation. Four of the tested serum vitamin concentrations increased from pre-to postsupplementation: vitamin A-retinol, vitamin B6, vitamin E-a-tocopherol; and folate (all p < 0.05). The increase in serum 25-OH vitamin D approached significance ( p = 0.063). No differences were found in dietary intake pre-to postsupplementation, suggesting that blood nutrient level increases were caused by EMP + . Conclusions:In this open prospective study, short-term use of EMP + in children with BPSD appeared safe and welltolerated, with a side effect profile preferable to first-line psychotropic drugs for pediatric bipolar spectrum disorders. A double-blind, randomized clinical trial is feasible, appears safe, and is warranted by open-label clinical outcomes and plausible mechanisms of action, combined with documentation of increased serum concentrations of specific micronutrients.

show abstract

Nutrition and Depression: The Role of Folate

Cited by 159 publications

References 30 publications

Is there any relationship between dietary patterns and depression and anxiety in Chinese adolescents?

Is there any relationship between dietary patterns and depression and anxiety in Chinese adolescents?

The prevalence and risk factors for age-related macular degeneration in rural–urban India, Sankara Nethralaya Rural–Urban Age-related Macular degeneration study, Report No. 1

Nutritional and Safety Outcomes from an Open-Label Micronutrient Intervention for Pediatric Bipolar Spectrum Disorders

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