“…Importantly, there is substantial experimental, epidemiological, and clinical evidence suggesting that consumption of n-3 polyunsaturated fatty acids (PUFA), including docosahexaenoic acid (DHA, 22∶6 Δ4,7,10,13,16,19 ) and eicosapentaenoic acid (EPA, 20∶5 Δ5,8,11,14,17 ) is protective against colon tumorigenesis [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45]. However, the exact mechanisms by which n-3 PUFA function as chemopreventive agents have not been fully elucidated.…”