Nutrition

Rogers, Adrianne E.

doi:10.1016/b978-0-12-074901-0.50013-7

Cited by 48 publications

(15 citation statements)

References 162 publications

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“…Afterwards, the rats were weight-matched and assigned to four groups: (1) 5 fed ad libitum (control), (2) 5 allowed to feed ad libitum and subjected to the kindling procedure (kindled control), (3) 5 calorically restricted (experimental) and (4) 5 subjected to CR plus kindling (kindled experimental). CR was achieved by feeding rats with a normal diet (2018S, Harlan Laboratories) to 85% of the daily allowance based on the body weights (recorded every day) of rats allowed to feed ad libitum (Rogers, 1979). The animals were kept 30 days on their respective diets before stereotaxic surgery; each group was housed separately under standard conditions.…”

Section: Methodsmentioning

confidence: 99%

Caloric restriction protects against electrical kindling of the amygdala by inhibiting the mTOR signaling pathway

Phillips-Farfán

Rubio

Ramírez

et al. 2015

Front. Cell. Neurosci.

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Caloric restriction (CR) has been shown to possess antiepileptic properties; however its mechanism of action is poorly understood. CR might inhibit the activity of the mammalian or mechanistic target of rapamycin (mTOR) signaling cascade, which seems to participate crucially in the generation of epilepsy. Thus, we investigated the effect of CR on the mTOR pathway and whether CR modified epilepsy generation due to electrical amygdala kindling. The former was studied by analyzing the phosphorylation of adenosine monophosphate-activated protein kinase, protein kinase B and the ribosomal protein S6. The mTOR cascade is regulated by energy and by insulin levels, both of which may be changed by CR; thus we investigated if CR altered the levels of energy substrates in the blood or the level of insulin in plasma. Finally, we studied if CR modified the expression of genes that encode proteins participating in the mTOR pathway. CR increased the after-discharge threshold and tended to reduce the after-discharge duration, indicating an anti-convulsive action. CR diminished the phosphorylation of protein kinase B and ribosomal protein S6, suggesting an inhibition of the mTOR cascade. However, CR did not change glucose, β-hydroxybutyrate or insulin levels; thus the effects of CR were independent from them. Interestingly, CR also did not modify the expression of any investigated gene. The results suggest that the anti-epileptic effect of CR may be partly due to inhibition of the mTOR pathway.

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Section: Methodsmentioning

confidence: 99%

Caloric restriction protects against electrical kindling of the amygdala by inhibiting the mTOR signaling pathway

Phillips-Farfán

Rubio

Ramírez

et al. 2015

Front. Cell. Neurosci.

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“…Rats are animals which show continuous growth during their lives, changing the growth rate according to age [16]. Thus, the 2-and 3-month-old rats showed higher body weight gain than the others, as a function of the growth phase.…”

Section: Discussionmentioning

confidence: 99%

Effects of Aging on the Energy Balance of Pregnant Rats

Luz

Griggio²

1998

Ann Nutr Metab

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In pregnant and non-pregnant female rats at various ages the energy balance was determined to study the age-induced alterations in the mother and conceptus. The animals were anesthetized and the conceptus removed and separated into male, female, and placental tissues. The animals were then killed and the carcasses prepared for energy balance determination. The results obtained showed that the older animals gained less energy in the body and had lower gross food efficiency than the younger animals. The number, energy and weight of the offspring were not affected by the mother’s age. Nevertheless, due to its constant growth during life, the rat is not the best model to study age-related processes.

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“…Rats are animals which show continuous growth during their lives, changing their growth rate according to age [26]. A higher growth rate is observed from birth to 3 months, when animals reach sexual maturity [27].…”

Section: Discussionmentioning

confidence: 99%

Impact of Maternal Food Restriction on Cold-Induced Thermogenesis in the Offspring

Luz

Griggio²,

Vieira³

2003

Neonatology

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Food restriction imposed during pregnancy usually leads to many alterations in the development of the conceptus. Some of these alterations can be reverted after birth by adequate nutritional rehabilitation, while there are others which are permanent. The aim of this article is to study the influence of maternal food restriction on offspring thermoregulation. Offspring of dams with food restriction during pregnancy (50%) were fed ad libitum after weaning. Rectal temperature was measured every 15 days from weaning to the 90th day of life. From the 60th to the 90th day the animals were either acclimated at 25 or 5°C. On the 90th day the animals were killed and their carcasses were processed for energy balance analysis and body composition determination. The results showed that animals from food-restricted mothers were not able to maintain body temperature for a longer period of time than the pups from control dams. Energy balance parameters and body composition did not show significant differences between rats from control and food-restriction mothers at the same environmental temperature. Thus, the results suggest that intrauterine food restriction may delay the development of the hypothalamus-thyroid axis which, in turn, may affect brown adipose tissue development leading to inefficient thermoregulation during neonatal life.

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Nutrition

Cited by 48 publications

References 162 publications

Caloric restriction protects against electrical kindling of the amygdala by inhibiting the mTOR signaling pathway

Caloric restriction protects against electrical kindling of the amygdala by inhibiting the mTOR signaling pathway

Effects of Aging on the Energy Balance of Pregnant Rats

Impact of Maternal Food Restriction on Cold-Induced Thermogenesis in the Offspring

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