Nutrients Intake Is Associated with DNA Methylation of Candidate Inflammatory Genes in a Population of Obese Subjects

Bollati, Valentina; Favero, Chiara; Albetti, Benedetta; Tarantini, Letizia; Moroni, Alice; Byun, Hyang‐Min; Motta, Valeria; Conti, Diana Misaela; Tirelli, Amedea Silvia; Vigna, Luisella; Bertazzi, Pier Alberto; Pesatori, Angela Cecilia

doi:10.3390/nu6104625

Cited by 47 publications

(44 citation statements)

References 39 publications

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“…(Bollati, 2014a, Bollati et al, 2014b) The study subjects were predominantly female (80% of the population), 122 were obese (66%) and 64 were overweight (34%), with a mean age of 51 years.…”

Section: Resultsmentioning

confidence: 99%

“…Although the prevalence of overweight/obese males is higher than the prevalence of overweight/obese females in the general population, our study group included a higher proportion of overweight/obese women. One possible explanation is that women are, in general, more concerned about their appearance than men, so they may be more likely to seek out personalized diet protocols and diet centers that provide periodic medical checks (Bollati et al, 2014a). …”

Section: Discussionmentioning

confidence: 99%

“…In detail, we measured DNA methylation in a set of candidate genes, including of CD14, TLR4 and TNF-α (Bollati et al, 2014a), selected for the important roles that they play in the inflammatory pathway. CD14 is a pattern recognition receptor in the innate immune response against microorganisms and other exogenous and endogenous stress factors.…”

Section: Introductionmentioning

confidence: 99%

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Particulate matter exposure is associated with inflammatory gene methylation in obese subjects

Cantone

Iodice

Tarantini

et al. 2017

Environmental Research

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BackgroundOverweight and obesity are becoming more widespread with alarming projections for the coming years. Obesity may increase susceptibility to the adverse effects of PM exposure, exacerbating the effects on cardiovascular diseases and altering the biomarkers of vascular inflammation. The associated biological mechanisms have not been fully understood yet; the common denominator in the pathogenesis of the co-morbidities of obesity is the presence of an active, low-grade inflammatory process. DNA methylation has been shown to regulate inflammatory pathways that are responsible for the development of cardiovascular diseases.ObjectivesThe aim of the study was to investigate, in a population of overweight/obese subjects, the effects of PM on blood DNA methylation in genes associated to inflammatory response.MethodsUsing bisulfite pyrosequencing, we measured DNA methylation in peripheral blood mononuclear cells from 186 overweighted/obese subjects. In particular, we quantified DNA methylation in a set of 3 candidate genes, including CD14, TLR4 and TNF-α, because of the important roles that these genes play in the inflammatory pathway. Personal exposure to PM10 was estimated for each subject based on the local PM10 concentrations, measured by monitoring stations at residential address. Repeated measure models were used to evaluate the association of PM10 with each genes, accounting for possible correlations among the genes that regulate the same inflammatory pathway.ResultsWe found an inverse association between the daily PM10 exposure and the DNA methylation of inflammatory genes, measured in peripheral blood of healthy overweight/obese subjects. Considering different exposure time-windows, the effect on CD14 and TLR4 methylation was observed, respectively, in days 4–5-6, and days 6–7-8. TNF-α methylation was not associated to PM10.ConclusionsOur findings support a picture in which PM10 exposure and transcriptional regulation of inflammatory gene pathway in obese subjects are associated.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Particulate matter exposure is associated with inflammatory gene methylation in obese subjects

Cantone

Iodice

Tarantini

et al. 2017

Environmental Research

Self Cite

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“…Many dietary factors and supplements can affect epigenetic patterns directly or indirectly [101]. Some dietary factors inactivate the DNMT enzyme and thereby directly affect DNA methylation patterns [102].…”

Section: Nutrition Therapy In the Epigenetic Fieldmentioning

confidence: 99%

Mitochondrial Epigenetics and Environmental Exposure

Lambertini

Byun

2016

Curr Envir Health Rpt

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The rising toll of chronic and debilitating diseases brought about by the exposure to an ever expanding number of environmental pollutants and socio-economic factors is calling for action. The understanding of the molecular mechanisms behind the effects of environmental exposures can lead to the development of biomarkers that can support the public health fields of both early diagnosis and intervention to limit the burden of environmental diseases. The study of mitochondrial epigenetics carries high hopes to provide important biomarkers of exposure and disease. Mitochondria are in fact on the frontline of the cellular response to the environment. Modifications of the epigenetic factors regulating the mitochondrial activity are emerging as informative tools that can effectively report on the effects of the environment on the phenotype. Here, we will discuss the emerging field of mitochondrial epigenetics. This review describes the main epigenetic phenomena that modify the activity of the mitochondrial DNA including DNA methylation, long and short non-coding RNAs. We will discuss the unique pattern of mitochondrial DNA methylation, describe the challenges of correctly measuring it, and report on the existing studies that have analysed the correlation between environmental exposures and mitochondrial DNA methylation. Finally, we provide a brief account of the therapeutic approaches targeting mitochondria currently under consideration.

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“…In addition, the TCF7L2 gene shows multiple SNPs at CpG sites which can have effects on methylation levels, not only at the site, but also on surrounding regions, hence linking genetic variation to epigenetic change and increasing the number of regulatory factors which need to be considered and which can respond to environmental pressures. Furthermore twenty-six micro RNAs transcription start sites have been described with close proximity to TCF7L2 chromatin occupancy sites (Lan et al 2012) and Bollati et al (2014) has described methylation at inflammatory genes sites in obese subjects in response to nutrient intake.…”

Section: Tcf7l2 Gene Epigenetics and Mediterranean Dietmentioning

confidence: 99%

Living long and ageing well: is epigenomics the missing link between nature and nurture?

2015

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Human longevity is a complex trait and increasingly we understand that both genes and lifestyle interact in the longevity phenotype. Non-genetic factors, including diet, physical activity, health habits, and psychosocial factors contribute approximately 50% of the variability in human lifespan with another 25% explained by genetic differences. Family clusters of nonagenarian and centenarian siblings, who show both exceptional age-span and health-span, are likely to have inherited facilitatory gene groups, but also have nine decades of life experiences and behaviours which have interacted with their genetic profiles. Identification of their shared genes is just one small step in the link from genes to their physical and psychological profiles. Behavioural genomics is beginning to demonstrate links to biological mechanisms through regulation of gene expression, which directs the proteome and influences the personal phenotype. Epigenetics has been considered the missing link between nature and nurture. Although there is much that remains to be discovered, this article will discuss some of genetic and environmental factors which appear important in good quality longevity and link known epigenetic mechanisms to themes identified by nonagenarians themselves related to their longevity. Here we suggest that exceptional 90-year old siblings have adopted a range of behaviours and life-styles which have contributed to their ageing-well-phenotype and which link with important public health messages.

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Nutrients Intake Is Associated with DNA Methylation of Candidate Inflammatory Genes in a Population of Obese Subjects

Cited by 47 publications

References 39 publications

Particulate matter exposure is associated with inflammatory gene methylation in obese subjects

Particulate matter exposure is associated with inflammatory gene methylation in obese subjects

Mitochondrial Epigenetics and Environmental Exposure

Living long and ageing well: is epigenomics the missing link between nature and nurture?

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