Nutrients in the Prevention of Osteoporosis in Patients with Inflammatory Bowel Diseases

Ratajczak, Alicja Ewa; Rychter, Anna M.; Zawada, Agnieszka; Dobrowolska, Agnieszka; Krela‐Kaźmierczak, Iwona

doi:10.3390/nu12061702

Cited by 28 publications

(34 citation statements)

References 131 publications

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“…Therefore, IBD patients should be regularly monitored with regard to malnutrition [ 12 ]. Calcium and vitamin D are the most commonly discussed micronutrients in terms of osteoporosis prevention [ 13 , 14 , 15 , 16 ]; nevertheless, vitamin B12, folic acid, vitamin K, vitamin C, phosphate, magnesium and sodium also play an important role in the prevention of osteoporosis [ 17 ]. According to Owczarek et al, the key nutrients for IBD patients comprise iron, calcium, vitamin D, vitamins B, vitamin A and zinc [ 18 ], but other components of the diet, such as other micronutrients, should be taken into consideration as well.…”

Section: Nutrition In Ibdmentioning

confidence: 99%

“…Fortunately, in the recent years, the prevalence of cigarette smoking among IBD patients has reduced in Western countries [ 31 ]. It has been well established that the steroids and biopharmaceuticals used in the IBD therapy also affect bone mineral density [ 17 ]. In fact, Sole reported that infliximab increased BMD of the femoral neck in patients suffering from rheumatoid arthritis [ 32 ].…”

Section: Osteoporosis In Ibdmentioning

confidence: 99%

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Do Only Calcium and Vitamin D Matter? Micronutrients in the Diet of Inflammatory Bowel Diseases Patients and the Risk of Osteoporosis

et al. 2021

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Osteoporosis is one of the most common extraintestinal complications among patients suffering from inflammatory bowel diseases. The role of vitamin D and calcium in the prevention of a decreased bone mineral density is well known, although other nutrients, including micronutrients, are also of extreme importance. Despite the fact that zinc, copper, selenium, iron, cadmium, silicon and fluorine have not been frequently discussed with regard to the prevention of osteoporosis, it is possible that a deficiency or excess of the abovementioned elements may affect bone mineralization. Additionally, the risk of malnutrition, which is common in patients with ulcerative colitis or Crohn’s disease, as well as the composition of gut microbiota, may be associated with micronutrients status.

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Section: Nutrition In Ibdmentioning

confidence: 99%

Section: Osteoporosis In Ibdmentioning

confidence: 99%

Do Only Calcium and Vitamin D Matter? Micronutrients in the Diet of Inflammatory Bowel Diseases Patients and the Risk of Osteoporosis

et al. 2021

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“…Additionally, infliximab possibly increases the N-terminal telopeptide of type I collagen. However, research regarding the association between the use of infliximab and BMD are contradictory [38].…”

Section: Pharmacological Treatment In Ibdmentioning

confidence: 99%

“…Vitamin C is one of the nutrients which can affect BMD in various mechanisms [61]. On the other hand, nutritional deficiency of other vitamins and minerals, such as calcium and vitamin D, also influence bone mineral density (BMD) [38]. Moreover, the exclusion of other covariates is difficult and many research studies on the association between BMD and vitamin C intake have been observational.…”

Section: Vitamin C and Bone Tissue In Ibd Patientsmentioning

confidence: 99%

Vitamin C Deficiency and the Risk of Osteoporosis in Patients with an Inflammatory Bowel Disease

et al. 2020

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Recent research studies have shown that vitamin C (ascorbic acid) may affect bone mineral density and that a deficiency of ascorbic acid leads to the development of osteoporosis. Patients suffering from an inflammatory bowel disease are at a risk of low bone mineral density. It is vital to notice that patients with Crohn’s disease and ulcerative colitis also are at risk of vitamin C deficiency which is due to factors such as reduced consumption of fresh vegetables and fruits, i.e., the main sources of ascorbic acid. Additionally, some patients follow diets which may provide an insufficient amount of vitamin C. Moreover, serum vitamin C level also is dependent on genetic factors, such as SLC23A1 and SLC23A2 genes, encoding sodium-dependent vitamin C transporters and GSTM1, GSTP1 and GSTT1 genes which encode glutathione S-transferases. Furthermore, ascorbic acid may modify the composition of gut microbiota which plays a role in the pathogenesis of an inflammatory bowel disease.

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“…The most discussed nutrients are vitamin D and calcium. However, sufficient intake of other diet compounds, e.g., protein, magnesium, copper, and zinc, are also essential elements of osteoporosis prevention and treatment [39][40][41].…”

Section: Introductionmentioning

confidence: 99%

Impact of Cigarette Smoking on the Risk of Osteoporosis in Inflammatory Bowel Diseases

Ratajczak

Szymczak-Tomczak

Rychter

et al. 2021

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Cigarette smoking constitutes one of the most important modifiable factors of osteoporosis, as well as contributes to an early death, tumors, and numerous chronic diseases. The group with an increased risk of a lower bone mineral density are patients suffering from inflammatory bowel diseases. In fact, tobacco smoke, which contains more than 7000 chemical compounds, affects bone mineral density (BMD) both directly and indirectly, as it has an impact on the RANK-RANKL-OPG pathway, intestinal microbiota composition, and calcium–phosphate balance. Constant cigarette use interferes with the production of protective mucus and inhibits the repair processes in the intestinal mucus. Nicotine as well as the other compounds of the cigarette smoke are important risk factors of the inflammatory bowel disease and osteoporosis. Additionally, cigarette smoking may decrease BMD in the IBD patients. Interestingly, it affects patients with Crohn’s disease and ulcerative colitis in different ways—on the one hand it protects against ulcerative colitis, whereas on the other it increases the risk of Crohn’s disease development. Nevertheless, all patients should be encouraged to cease smoking in order to decrease the risk of developing other disorders.

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Nutrients in the Prevention of Osteoporosis in Patients with Inflammatory Bowel Diseases

Cited by 28 publications

References 131 publications

Do Only Calcium and Vitamin D Matter? Micronutrients in the Diet of Inflammatory Bowel Diseases Patients and the Risk of Osteoporosis

Do Only Calcium and Vitamin D Matter? Micronutrients in the Diet of Inflammatory Bowel Diseases Patients and the Risk of Osteoporosis

Vitamin C Deficiency and the Risk of Osteoporosis in Patients with an Inflammatory Bowel Disease

Impact of Cigarette Smoking on the Risk of Osteoporosis in Inflammatory Bowel Diseases

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