Nutrients and rheumatoid arthritis: From the perspective of neutrophils

Shao, Yaru; Xu, Dan-Yi; Lin, Jenshan

doi:10.3389/fimmu.2023.1113607

Cited by 8 publications

(5 citation statements)

References 75 publications

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“…RA in ammation causes changes in the structure of HDL that lead to stimulation of LDL oxidation and plaque formation. Dysfunctional HDL can further exacerbate LDL metabolic abnormalities and increase the risk of cardiovascular disease [52]. Also, our result showed a signi cant negative correlation between FABP4 plasma levels with HDL and LDL levels in patients RA (r =-0.224, P = 0.085; r =-0.098, P = 0.454, respectively), which may re ect Dyslipidemia in these patients.…”

Section: Discussionsupporting

confidence: 51%

FABP4 and S100A12, a notable link between inflammatory mediators and cardiovascular risk in rheumatoid arthritis

khoobbakht,

Roghani,

Soufivand

et al. 2024

Preprint

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Background: 50% of the deaths of RA patients are due to cardiovascular diseases, and inflammation plays an important role in its pathogenesis. FABP4 and S100A12 are involved as inflammatory mediators in the pathogenesis of CVD. For the first time, in a recent study, we evaluated the association between FABP4 and S100A12 plasma concentrations with cardiovascular risk factors in RA patients. Material and methods: 60 patients with RA (30 newly diagnosed and 30 under treatment) and 30 healthy individuals participated in this study with their personal consent. FABP4 and S100A12 plasma concentrations were measured by ELISA (enzyme-linked immunosorbent assay) method. Using ADVIA 1800 Clinical Chemistry System based on latex-enhanced immunoturbidimetric, HS-CRP concentration was calculated. Results: The FABP4 plasma concentration was significantly elevated in the newly diagnosed and under-treatment RA patients compared to healthy subjects (P <0.001 and P = 0.008, respectively). The plasma levels of S100A12 were remarkably higher in the new case compared to the control groups (P =0.001).There was a significantly positive association between the FABP4 and S100A12 with NT-proBNP(r =0.493, P < 0.001; r =0.445, P < 0.001, respectively). Conclusion: FABP4 and S100A12 correlate with cardiovascular biomarkers in RA patients.

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Section: Discussionsupporting

confidence: 51%

FABP4 and S100A12, a notable link between inflammatory mediators and cardiovascular risk in rheumatoid arthritis

khoobbakht,

Roghani,

Soufivand

et al. 2024

Preprint

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“…Prior research has shown that fruits and vegetables are crucial for maintaining good health due to their nutrient content and anti-inflammatory properties ( 45 ). Consuming fresh fruits and vegetables is beneficial in RA and may be related to the fact that macronutrients and micronutrients modulate the pathogenesis of RA by regulating the migration and activity of neutrophils ( 46 ). However, our study did not find a causal association between the two, and even in the PsA causal association study, we found Fresh fruit intake as a risk factor.…”

Section: Discussionmentioning

confidence: 99%

Diet affects inflammatory arthritis: a Mendelian randomization study of 30 dietary patterns causally associated with inflammatory arthritis

Wang,

Wu,

et al. 2024

Front. Nutr.

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BackgroundThe causal associations between dietary intake and the risk and severity of Inflammatory Arthritis (IA) are currently unknown.ObjectiveIn this study, we aimed to investigate the causal relationship between nine dietary categories (30 types of diet) and IA using Mendelian randomization (MR).MethodsWe analyzed data from 30 diets and IA in a genome-wide association study (GWAS). Single nucleotide polymorphisms (SNPs) that could influence the results of MR analyses were screened out through the Mendelian Randomization Pleiotropy RESidual Sum and Outlier (MR-PRESSO) test. SNPs were analyzed through two-sample bidirectional MR using inverse variance weighting, MR-Egger regression, and weighted median method. The multiplicity and heterogeneity of SNPs were assessed using MR-Egger intercept term tests and Cochran’s Q tests. FDR correction was used to correct the p-values.ResultsIVW results showed that Beef intake [Odds ratio (OR) = 2.862; 95% confidence interval (CI), 1.360–6.021, p = 0.006, p_fdr < 0.05] was positively associated with rheumatoid arthritis(RA); Dried fruit intake (OR = 0.522; 95% CI, 0.349–0.781, p = 0.002, p_fdr < 0.05), and Iron intake (OR = 0.864; 95%CI, 0.777–0.960, p = 0.007, p_fdr < 0.05) were negatively associated with RA, all of which were evidence of significance. Fresh fruit intake (OR = 2.528. 95% CI, 1.063–6.011, p = 0.036, p_fdr > 0.05) was positively associated with psoriatic arthritis (PsA); Cheese intake (OR = 0.579; 95% CI, 0.367–0.914, p = 0.019, p_fdr > 0.05) was negatively associated with PsA; both were suggestive evidence. Processed meat intake (OR = 0.238; 95% CI, 0.100–0.565, p = 0.001, p_fdr < 0.05) was negatively associated with reactive arthritis (ReA), a protective factor, and significant evidence. All exposure data passed the heterogeneity check (Cochrane’s Q test p > 0.05) and no directional pleiotropy was detected. Leave-one-out analyses demonstrated the robustness of the causal relationship in the positive results.ConclusionOur study presents genetic evidence supporting a causal relationship between diet and an increased risk of IA. It also identifies a causal relationship between various dietary modalities and different types of IA. These findings have significant implications for the prevention and management of IA through dietary modifications.

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“…Different micronutrients relate to neutrophil biology in homeostasis and disease states ( 174 ), in particular, Vitamin C ( 175 – 178 ), iron ( 179 – 181 ), zinc ( 182 – 185 ), Vitamin D ( 186 , 187 ) and Vitamin A ( 188 , 189 ). In general, a deficiency in any one of these micronutrients is associated with dysregulated neutrophil functions, particularly neutrophil recruitment, degranulation, ROS formation and NETosis, resulting in higher susceptibility to recurrent and severe infections.…”

Section: Regulation Of Neutrophil Functions In Various Nutrient Envir...mentioning

confidence: 99%

A metabolic perspective of the neutrophil life cycle: new avenues in immunometabolism

Thind,

Uhlig,

Glogauer

et al. 2024

Front. Immunol.

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Neutrophils are the most abundant innate immune cells. Multiple mechanisms allow them to engage a wide range of metabolic pathways for biosynthesis and bioenergetics for mediating biological processes such as development in the bone marrow and antimicrobial activity such as ROS production and NET formation, inflammation and tissue repair. We first discuss recent work on neutrophil development and functions and the metabolic processes to regulate granulopoiesis, neutrophil migration and trafficking as well as effector functions. We then discuss metabolic syndromes with impaired neutrophil functions that are influenced by genetic and environmental factors of nutrient availability and usage. Here, we particularly focus on the role of specific macronutrients, such as glucose, fatty acids, and protein, as well as micronutrients such as vitamin B3, in regulating neutrophil biology and how this regulation impacts host health. A special section of this review primarily discusses that the ways nutrient deficiencies could impact neutrophil biology and increase infection susceptibility. We emphasize biochemical approaches to explore neutrophil metabolism in relation to development and functions. Lastly, we discuss opportunities and challenges to neutrophil-centered therapeutic approaches in immune-driven diseases and highlight unanswered questions to guide future discoveries.

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Nutrients and rheumatoid arthritis: From the perspective of neutrophils

Cited by 8 publications

References 75 publications

FABP4 and S100A12, a notable link between inflammatory mediators and cardiovascular risk in rheumatoid arthritis

FABP4 and S100A12, a notable link between inflammatory mediators and cardiovascular risk in rheumatoid arthritis

Diet affects inflammatory arthritis: a Mendelian randomization study of 30 dietary patterns causally associated with inflammatory arthritis

A metabolic perspective of the neutrophil life cycle: new avenues in immunometabolism

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