“…Deficiencies of several B vitamins, including thiamine (B1), riboflavin (B2), niasin (B3), pyridoxine (B6), folate (B9) and cobalamin (B12), have been related with cognitive dysfunction in many observational study (Riedel et al, 1998). In some studies, pathophysiological models have been formulated, including the association of B vitamin deficiencies with metabolic disturbances in the structural constituents of cerebral tissue, such as phospholipids and myelin, as well as in signaling molecules, such as neurotransmitters (Rampersaud et al, 2003).…”