Nutrient Transport Pathways Across the Epithelium of the Placenta

Smith, Carl H.; Moe, A.J.; Ganapathy, Vadivel

doi:10.1146/annurev.nu.12.070192.001151

Cited by 113 publications

(40 citation statements)

References 146 publications

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“…Specific transport systems have been identified in the placenta that regulate the transport of a variety of nutrients including vitamins, calcium, fatty acids, and glucose, the primary energy source during fetal life [1][2][3][4][5][6]. Additionally, specific transport systems have been identified involved in the transport of amino acids [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

IGF regulation of neutral amino acid transport in the BeWo choriocarcinoma cell line (b30 clone): Evidence for MAP kinase-dependent and MAP kinase-independent mechanisms

Fang¹,

Mao²,

Smith³

et al. 2006

Growth Hormone & IGF Research

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Section: Introductionmentioning

confidence: 99%

IGF regulation of neutral amino acid transport in the BeWo choriocarcinoma cell line (b30 clone): Evidence for MAP kinase-dependent and MAP kinase-independent mechanisms

Fang¹,

Mao²,

Smith³

et al. 2006

Growth Hormone & IGF Research

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“…Placenta plays an obligatory role in providing the developing fetus with essential nutrients and metabolic fuels (1,2). This function is facilitated by the presence of specific transport mechanisms in the maternal facing brush border membrane and the fetal facing basal membrane of the placental syncytiotrophoblast.…”

mentioning

confidence: 99%

Primary Structure and Functional Characteristics of a Mammalian Sodium-coupled High Affinity Dicarboxylate Transporter

Kekuda¹,

Wang²,

Huang³

et al. 1999

Journal of Biological Chemistry

122

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We have cloned a Na ؉ -dependent, high affinity dicarboxylate transporter (NaDC3) from rat placenta. NaDC3 exhibits 48% identity in amino acid sequence with rat NaDC1, a Na ؉ -dependent, low affinity dicarboxylate transporter. NaDC3-specific mRNA is detectable in kidney, brain, liver, and placenta. When expressed in mammalian cells, NaDC3 mediates Na ؉ -dependent transport of succinate with a K t of 2 M. The transport function of NaDC3 shows a sigmoidal relationship with regard to Na ؉ concentration, with a Hill coefficient of 2.7. NaDC3 accepts a number of dicarboxylates including dimethylsuccinate as substrates and excludes monocarboxylates. Li ؉ inhibits NaDC3 in the presence of Na ؉ . Transport of succinate by NaDC3 is markedly influenced by pH, the transport function gradually decreasing when pH is acidified from 8.0 to 5.5. In contrast, the influence of pH on NaDC3-mediated transport of citrate is biphasic in which a pH change from 8.0 to 6.5 stimulates the transport and any further acidification inhibits the transport. In addition, the potency of citrate to compete with NaDC3-mediated transport of succinate increases 25-fold when pH is changed from 7.5 to 5.5. These data show that NaDC3 interacts preferentially with the divalent anionic species of citrate. This represents the first report on the cloning and functional characterization of a mammalian Na ؉

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“…The placenta also functions in the transcellular transfer of nutrients from mother to developing fetus. The syncytiotrophoblast, the absorptive epithelium of the placenta, possesses specific transport systems for several nutrients (1). Recent studies (2)(3)(4) have demonstrated the presence of a Na ϩ -dependent vitamin transport system in the placenta that accepts as substrates the water-soluble vitamins pantothenate and biotin and the essential metabolite lipoate.…”

mentioning

confidence: 99%

Cloning and Functional Expression of a cDNA Encoding a Mammalian Sodium-dependent Vitamin Transporter Mediating the Uptake of Pantothenate, Biotin, and Lipoate

Prasad¹,

Wang²,

Kekuda³

et al. 1998

Journal of Biological Chemistry

209

109

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Nutrient Transport Pathways Across the Epithelium of the Placenta

Cited by 113 publications

References 146 publications

IGF regulation of neutral amino acid transport in the BeWo choriocarcinoma cell line (b30 clone): Evidence for MAP kinase-dependent and MAP kinase-independent mechanisms

IGF regulation of neutral amino acid transport in the BeWo choriocarcinoma cell line (b30 clone): Evidence for MAP kinase-dependent and MAP kinase-independent mechanisms

Primary Structure and Functional Characteristics of a Mammalian Sodium-coupled High Affinity Dicarboxylate Transporter

Cloning and Functional Expression of a cDNA Encoding a Mammalian Sodium-dependent Vitamin Transporter Mediating the Uptake of Pantothenate, Biotin, and Lipoate

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