Nutrient-toxic element mixtures and the early postnatal gut microbiome in a United States longitudinal birth cohort

Laue, Hannah E.; Moroishi, Yuka; Jackson, Brian P.; Palys, Thomas J.; Madan, Juliette C.

doi:10.1016/j.envint.2020.105613

Cited by 40 publications

(23 citation statements)

References 66 publications

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“…Several human and animal studies have investigated associations between MeHg exposure and gut microbiota communities, and results have varied between studies. For example, among 179 6-week-old infants enrolled in the New Hampshire Birth Cohort Study, exposure to 16 trace elements, including THg, was assessed in infant toenails, and the infant gut microbiota was determined using 16S gene profiling ( Laue et al, 2020 ). However, there were no statistically significant associations between toenail THg and ASVs in adjusted regression models ( Laue et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

“…For example, among 179 6-week-old infants enrolled in the New Hampshire Birth Cohort Study, exposure to 16 trace elements, including THg, was assessed in infant toenails, and the infant gut microbiota was determined using 16S gene profiling ( Laue et al, 2020 ). However, there were no statistically significant associations between toenail THg and ASVs in adjusted regression models ( Laue et al, 2020 ). Among two cohorts of pregnant mothers, fecal MeHg was positively correlated with several gut microbiota taxa, although specific taxa differed between both cohorts, and associations differed longitudinally between early and late gestation ( n = 17, Rothenberg et al, 2016 ; n = 52, Rothenberg et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, associations were observed (positive and negative) between fecal MeHg and gut microbiota taxa ( Table 4 , Figure 3 , and Supplementary Tables 6 , 7 ), which differed from those noted in prior studies ( Rothenberg et al, 2016 , 2019 ; Bridges et al, 2018 ; Zhang et al, 2019 ; Lin et al, 2020 ). The results in both human and animal studies suggest that the direction (and strength) of the association between gut microbiota taxa and MeHg depends potentially on several factors, such as diet, MeHg dose, timing of exposure, and co-exposure to other contaminants or nutrients ( Rothenberg et al, 2016 , 2019 ; Bridges et al, 2018 ; Guo et al, 2018 ; Zhang et al, 2019 ; Laue et al, 2020 ; Lin et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

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Fecal Methylmercury Correlates With Gut Microbiota Taxa in Pacific Walruses (Odobenus rosmarus divergens)

et al. 2021

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ObjectivesMethylmercury metabolism was investigated in Pacific walruses (Odobenus rosmarus divergens) from St. Lawrence Island, Alaska, United States.MethodsTotal mercury and methylmercury concentrations were measured in fecal samples and paired colon samples (n = 16 walruses). Gut microbiota composition and diversity were determined using 16S rRNA gene sequencing. Associations between fecal and colon mercury and the 24 most prevalent gut microbiota taxa were investigated using linear models.ResultsIn fecal samples, the median values for total mercury, methylmercury, and %methylmercury (of total mercury) were 200 ng/g, 4.7 ng/g, and 2.5%, respectively, while in colon samples, the median values for the same parameters were 28 ng/g, 7.8 ng/g, and 26%, respectively. In fecal samples, methylmercury was negatively correlated with one Bacteroides genus, while members of the Oscillospirales order were positively correlated with both methylmercury and %methylmercury (of total mercury). In colon samples, %methylmercury (of total mercury) was negatively correlated with members of two genera, Romboutsia and Paeniclostridium.ConclusionsMedian %methylmercury (of total mercury) was 10 times higher in the colon compared to the fecal samples, suggesting that methylmercury was able to pass through the colon into systemic circulation. Fecal total mercury and/or methylmercury concentrations in walruses were comparable to some human studies despite differences in seafood consumption rates, suggesting that walruses excreted less mercury. There are no members (at this time) of the Oscillospirales order which are known to contain the genes to methylate mercury, suggesting the source of methylmercury in the gut was from diet and not in vivo methylation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Fecal Methylmercury Correlates With Gut Microbiota Taxa in Pacific Walruses (Odobenus rosmarus divergens)

et al. 2021

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“…Human studies. Laue et al conducted a study on 179 6-week-old infants (18), the GM was assessed using 16S rRNA sequencing. They found that postnatal exposure to toxic elements was differentially associated with the infant microbiota.…”

Section: Data Collection and Analysismentioning

confidence: 99%

Influence of toxic metal exposure on the gut microbiota (Review)

et al. 2021

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The gut microbiota (GM) is composed of >100 trillion different organisms, including bacteria, viruses, fungi, archaea and protists, coexisting in a complex system. The GM can be very sensitive to drugs, diet or even environmental pollutants. In the present review, recent data related to the interaction between the GM and heavy/toxic metals are discussed, focusing on the compounds most widely distributed in the environment or considered biopersistent. There are data to suggest that exposure to metals can alter the composition, diversity, homogeneity and structure of the GM. The specific modifications reported are not homogeneous, and a number of factors may explain this variability, including differences in metal compound, exposure modalities (e.g., food, water, in vitro), exposure time, qualitative and quantitative diversity of bacterial species in basal microbiota and analytical issues. As regards metal nanoparticles, some authors foresee the premises for a safe preventive and therapeutic use, while others have revealed harmful effects on both the gut microbiome and health. These findings, which would benefit from the application of modern approaches such as metagenomic sequencing and metabolomics, seem to indicate structural and functional analysis of gut microbiota as an early biomarker of detrimental effects from exposure to metals.

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“…In addition to antibiotics [ 49 ], other medications commonly administered to mothers and/or infants that alter the intestinal microbiota include acid blocking agents [ 50 , 51 ], selective serotonin reuptake inhibitors, metformin and laxatives [ 52 , 53 ]. Recent demonstrations of altered infant microbiota with exposure to environmental toxins [ 54 , 55 ], maternal smoking [ 56 ], and proximity to furry animals [ 42 , 57 ] underscore the many factors affecting this community.…”

Section: Causes Of Neonatal Intestinal Dysbiosismentioning

confidence: 99%

Neonatal intestinal dysbiosis

et al. 2020

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The initial colonization of the neonatal intestinal tract is influenced by delivery mode, feeding, the maternal microbiota, and a host of environmental factors. After birth, the composition of the infant's microbiota undergoes a series of significant changes particularly in the first weeks and months of life ultimately developing into a more stable and diverse adult-like population in childhood. Intestinal dysbiosis is an alteration in the intestinal microbiota associated with disease and appears to be common in neonates. The consequences of intestinal dysbiosis are uncertain, but strong circumstantial evidence and limited confirmations of causality suggest that dysbiosis early in life can influence the health of the infant acutely, as well as contribute to disease susceptibility later in life.

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Nutrient-toxic element mixtures and the early postnatal gut microbiome in a United States longitudinal birth cohort

Cited by 40 publications

References 66 publications

Fecal Methylmercury Correlates With Gut Microbiota Taxa in Pacific Walruses (Odobenus rosmarus divergens)

Fecal Methylmercury Correlates With Gut Microbiota Taxa in Pacific Walruses (Odobenus rosmarus divergens)

Influence of toxic metal exposure on the gut microbiota (Review)

Neonatal intestinal dysbiosis

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