Nutrient sensing, signaling transduction, and autophagy in podocyte injury: implications for kidney disease

Zha, Dongqing; Wu, Xiaoyan

doi:10.1007/s40620-022-01365-2

Cited by 4 publications

(1 citation statement)

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“…Emerging evidence points to the dysregulation of nutrient sensing signaling and autophagy linking to a range of kidney diseases [87,88]. Several nutrient-sensing signals are involved in fetal programming [89], including silent information regulator T1 (SIRT1), peroxisome proliferator-activated receptors (PPARs), AMP-activated protein kinase (AMPK) and PPARγ co-activator 1α (PGC-1α).…”

Section: Disrupted Autophagy-nutrient Sensing Pathwaysmentioning

confidence: 99%

Melatonin and Kidney Health: From Fetal Stage to Later Life

Tang

Hsu

et al. 2023

IJMS

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Melatonin, an endogenous hormone mainly released at night by the pineal gland, has multifaceted biofunctions. Emerging evidence points to melatonin having a crucial role in kidney health and disease. As the prevalence of chronic kidney disease (CKD) is still rising, a superior strategy to advance global kidney health is needed to not just treat CKD, but prevent it early on. Adult kidney disease can have its origins in early life. This review aims to evaluate the recent literature regarding melatonin’s effect on kidney development, its clinical uses in the early stage of life, animal models documenting preventive applications of melatonin on offspring’s kidney-related disease, and a thorough summary of therapeutic considerations concerning melatonin supplementation.

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Section: Disrupted Autophagy-nutrient Sensing Pathwaysmentioning

confidence: 99%