Nutrient Sensing and the Oxidative Stress Response

Luo, Hanzhi; Chiang, Hou-Hsien; Louw, Makensie; Susanto, Albert; Chen, Danica

doi:10.1016/j.tem.2017.02.008

Cited by 89 publications

(57 citation statements)

References 106 publications

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“…sakei to the extensively studied topic of so-called complete calorie restricted diet, although in the present study glucose was the limiting factor. Complete caloric restriction is shown as a conserved mechanism in eukaryotes, from single-celled yeast to humans, to result in expanded healthy life span in response to a reduction of energy intake [ 49 – 52 ], and is found to act through mechanisms involving the redox balance [ 53 ]. For L .…”

Section: Discussionmentioning

confidence: 99%

Effects of glucose availability in Lactobacillus sakei; metabolic change and regulation of the proteome and transcriptome

et al. 2017

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Effects of glucose availability were investigated in Lactobacillus sakei strains 23K and LS25 cultivated in anaerobic, glucose-limited chemostats set at high (D = 0.357 h-1) and low (D = 0.045 h-1) dilution rates. We observed for both strains a shift from homolactic towards more mixed acid fermentation when comparing high to low growth rates. However, this change was more pronounced for LS25 than for 23K, where dominating products were lactate>formate>acetate≥ethanol at both conditions. A multivariate approach was used for analyzing proteome and transcriptome data from the bacterial cultures, where the predictive power of the omics data was used for identifying features that can explain the differences in the end-product profiles. We show that the different degree of response to the same energy restriction revealed interesting strain specific regulation. An elevated formate production level during slow growth, more for LS25 than for 23K, was clearly reflected in correlating pyruvate formate lyase expression. With stronger effect for LS25, differential expression of the Rex transcriptional regulator and NADH oxidase, a target of Rex, indicated that maintainance of the cell redox balance, in terms of the NADH/NAD+ ratio, may be a key process during the metabolic change. The results provide a better understanding of different strategies that cells may deploy in response to changes in substrate availability.

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Section: Discussionmentioning

confidence: 99%

Effects of glucose availability in Lactobacillus sakei; metabolic change and regulation of the proteome and transcriptome

et al. 2017

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“…In all of them telomere length was determined in either leukocytes or PBMC before and after the intervention. However, although the type of interventions described are known to impinge on oxidative-stress responses [78][79][80][81][82], only a few related telomere length measurements to changes in oxidative stressrelated parameters [62,64,65]. A brief description of these studies is summarized below.…”

Section: Non-pharmacological Interventionsmentioning

confidence: 99%

Oxidative stress, telomeres and cellular senescence: What non-drug interventions might break the link?

Erusalimsky

2020

Free Radical Biology and Medicine

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…Mitochondria are a key biological source of free radicals; in most circumstances, approximately 90% of cellular ROS are traceable back to mitochondria [ 13 , 14 ]. Electrons and protons (derived from oxidation of carbon-containing food molecules) are passed through the electron transport chain via a series of redox reactions, and pumped across the inner mitochondrial membrane, respectively (with the energy for the latter being provided by energy generated during the former).…”

Section: Redox-sensitive Signalling Effectsmentioning

confidence: 99%

The Ability of Exercise-Associated Oxidative Stress to Trigger Redox-Sensitive Signalling Responses

et al. 2017

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In this review, we discuss exercise as an oxidative stressor, and elucidate the mechanisms and downstream consequences of exercise-induced oxidative stress. Reactive oxygen species (ROS) are generated in the mitochondria of contracting skeletal myocytes; also, their diffusion across the myocyte membrane allows their transport to neighbouring muscle tissue and to other regions of the body. Although very intense exercise can induce oxidative damage within myocytes, the magnitudes of moderate-intensity exercise-associated increases in ROS are quite modest (~two-fold increases in intracellular and extracellular ROS concentrations during exercise), and so the effects of such increases are likely to involve redox-sensitive signalling effects rather than oxidative damage. Therefore, the responses of muscle and non-muscle cells to exercise-associated redox-sensitive signalling effects will be reviewed; for example, transcription factors such as Peroxisome Proliferator Activated Receptor-gamma (PPARγ) and Liver X-Receptor-alpha (LXRα) comprise redox-activable signalling systems, and we and others have reported exercise-associated modulation of PPARγ and/or LXRα-regulated genes in skeletal myocyte and in non-muscle cell-types such as monocyte-macrophages. Finally, the consequences of such responses in the context of management of chronic inflammatory conditions, and also their implications for the design of exercise training programmes (particularly the use of dietary antioxidants alongside exercise), will be discussed.

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Nutrient Sensing and the Oxidative Stress Response

Cited by 89 publications

References 106 publications

Effects of glucose availability in Lactobacillus sakei; metabolic change and regulation of the proteome and transcriptome

Effects of glucose availability in Lactobacillus sakei; metabolic change and regulation of the proteome and transcriptome

Oxidative stress, telomeres and cellular senescence: What non-drug interventions might break the link?

The Ability of Exercise-Associated Oxidative Stress to Trigger Redox-Sensitive Signalling Responses

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