Nutrient renal blood flow and its distribution in the unanesthetized dog

Steiner, Sheldon H.; King, Robert D.

doi:10.1016/0022-4804(70)90023-5

Cited by 21 publications

(7 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As known from experimental studies, the distribution of the renal blood flow varies throughout the cortex and the medulla. The renal perfusion gradually decreases from the outer cortex to the inner medulla with a more than fourfold drop [30,31,32,33]. Therefore, partial-volume effect or differences in the definition of the region of interest for the cortex may explain the discrepancy between methods with different spatial resolution as noted by Lerman et al [34].…”

Section: Cortical and Medullary Blood Flow Measurementsmentioning

confidence: 94%

Absolute renal blood flow quantification by dynamic MRI and Gd-DTPA

Vallée¹,

Lazeyras²,

Khan³

et al. 2000

European Radiology

View full text Add to dashboard Cite

The aim of this study was to demonstrate the feasibility of the absolute renal blood flow quantification using MRI and injection of contrast media. Using a T1-weighted fast gradient sequence following an intravenous bolus injection of Gd-DTPA, dynamic images of the kidney were obtained in patients with well-functioning native kidneys (n = 7) or transplant (n = 9), with significant renal artery stenosis (n = 4) and with renal failure (n = 7). After signal intensity calibration, the absolute renal perfusion was equal to the wash-in slope of the renal transit curve divided by the contrast medium concentration at the peak of the bolus in the aorta. The cortical blood flow was 2.54+/-1.16 ml/min per gram in well-functioning kidneys decreasing to 1.09+/-0.75 ml/min per gram in case of renal artery stenosis (p = 0.04) and to 0.51+/-0.34 ml/min per gram in case of renal failure (P<0.001). These measurements were in agreement with previous results obtained by other methods. A standard MRI imaging sequence and a simple model can provide realistic quantitative data on renal perfusion. This work justifies further studies to compare this model with a gold standard for renal blood flow measurements.

show abstract

Section: Cortical and Medullary Blood Flow Measurementsmentioning

confidence: 94%

Absolute renal blood flow quantification by dynamic MRI and Gd-DTPA

Vallée¹,

Lazeyras²,

Khan³

et al. 2000

European Radiology

View full text Add to dashboard Cite

show abstract

“…Although the long-lived mbidium-86 (half-life, 19 days) has been used experimentally for the estimation of renal blood flow, 28 " 30 the long half-life is not well suited to making serial measurements. The kinetics of Rb are similar to those of "Rb, but the half-life of 75 seconds makes this tracer suitable for repetitive in vivo imaging with the positron camera.…”

Section: Discussionmentioning

confidence: 99%

The effect of captopril on renal blood flow in renal artery stenosis assessed by positron tomography with rubidium-82.

et al. 1988

View full text Add to dashboard Cite

SUMMARY The sequence and magnitude of acute changes in renal blood flow following administration of captopril were determined in a canine model of acute unilateral renal artery stenosis using rubidium-82 and positron emission tomography. Data were recorded in each of nine dogs under three conditions: 1) during a baseline control interval, 2) during renal artery stenosis, and 3) during stenosis with intravenous injection of captopril (1.2 mg/kg). Mean arterial blood pressure was 108 ± 12 mm Hg at control, increased significantly to 125 ± 13 mm Hg (p<0.01) during stenosis, and decreased to 98 ± 13 mm/Hg (p<0.01) after captopril infusion. Mean renal blood flow was calculated using a steady state single compartment model from the images produced by positron emission tomography. The estimated flow to the affected kidney was 3.37 ± 1.48 ml/min/g at control, 0.86 ± 0.62 ml/min/g during stenosis ( p < 0.01), and 0.64 ± 0.57 ml/min/g after captopril administration (p= NS compared with precaptopril value). The estimated flow to the contralateral kidney was minimally reduced from a baseline of 3.84 ± 0.95 to 3.24 ±1,13 ml/min/g (p=NS) during stenosis and increased after captopril infusion (4.08 ± 0.94 ml/min/g; p = 0.01). These data suggest that repetitive imaging with positron emission tomography can be used to delineate acute changes in renal perfusion following captopril administration. (Hypertension 11: 217-222, 1988).

show abstract

“…This method is based upon the principle that the amount of 86Rb taken up by tissues is proportional to the fraction of the cardiac output perfusing those tissues in both normothermic and hypothermic animals. The validity of results obtained by the method in normothermic kidneys has been clearly demonstrated by a number of workers (Steiner & King, 1970;Deutsch & Dreichlinger, 1963;Girndt & Ochwadt, 1969). The validation depends on the measurement of renal arterial-venous differences of 86Rb, the time-course of 06Rb uptake and on comparison with other methods that depend on different principles.…”

Section: Introductionmentioning

confidence: 95%

Distribution of Blood Flow in the Hypothermic (27°C) Dog Kidney

1976

View full text Add to dashboard Cite

1. Renal function was measured in seven normo thermic (38 degrees C) and seven hypothermic (27 degrees C) dogs. 2. The glomerular filtration rate was 60 per cent lower in the hypothermic animals, and the renal blood flow as 51 per cent lower. The intrarenal distribution of blood flow was measured by the uptake of 86Rb from the blood into different regions of the kidney. Hypothermia reduced flow by 34 per cent in the outer cortex, 72 per cent in the inner cortex, 61 per cent in the outer medulla and 69 per cent in the inner medulla. 3. Radioautography indicated a high blood flow to an area of the outer medulla of hypothermic kidneys, which may indicate medullary blood flow "shunting". 4. The results have been discussed in relation to a number of clinical and experimental observations.

show abstract

Nutrient renal blood flow and its distribution in the unanesthetized dog

Cited by 21 publications

References 10 publications

Absolute renal blood flow quantification by dynamic MRI and Gd-DTPA

Absolute renal blood flow quantification by dynamic MRI and Gd-DTPA

The effect of captopril on renal blood flow in renal artery stenosis assessed by positron tomography with rubidium-82.

Distribution of Blood Flow in the Hypothermic (27°C) Dog Kidney

Contact Info

Product

Resources

About