Nutrient molecule corona: An update for nanomaterial-food component interactions

Activation of KLF6 by titanate nanofibers and regulatory roles of KLF6 on ATF3 in the endothelial monolayer and mouse aortas

“…67 Indeed, NMs could impair nutrient transport even without inducing acute damage to cells, which could be evaluated by using omics-techniques. 68 As such, the acute toxicity tests might not be enough to evaluate the biocompatibility of NMs, and omics-techniques may be needed to thoroughly assess the adverse health effects of NMs. Omics-techniques may also be needed to investigate the roles of KLFs in NM-induced toxic effects, as KLFs can regulate many downstream events which might be difficult to investigate by traditional approaches.…”

Graphene oxide links alterations of anti-viral signaling pathways with lipid metabolism via suppressing TLR3 in vascular smooth muscle cells

“…NMs including graphene oxide may modulate lipid metabolism, although the mechanism is not known. 63,64 Recently, it has been suggested that TLR-signaling is related to lipid metabolism. 65,66 For example, Castoldi et al recently reported that TLR-mediated triacylglycerol synthesis is related to the inflammatory function of macrophages.…”

Influences of repeated exposure to low levels of TiO2 nanoparticles on Kruppel‐like factors in 3D Caco‐2 spheroids and mouse intestines

“…However, it should be noticed that under in vivo conditions, high level of TiO 2 NPs (43.9 mg/kg) appeared to induce morphological changes of mouse intestines (Figure 10). We proposed before that NPs might impair the functions of intestinal cells even if the NPs are composed of biocompatible materials (Cao, 2022a; Cao et al, 2016). Recent studies also reported that TiO 2 NPs shortened the microvilli and impaired nutrient transport (Coméra et al, 2020; Gao et al, 2020; Richter et al, 2018).…”