Nutrient mixture from germinated legumes: Enhanced medicinal value with herbs‐attenuated liver cirrhosis

Nithyananthan, Subramaniyam; Keerthana, P; Umadevi, S.; Guha, Shreyoshi; Mir, Ishfaq Hassan; Behera, Jajnasenee; Thirunavukkarasu, Chinnasamy

doi:10.1111/jfbc.13085

Cited by 3 publications

(7 citation statements)

References 45 publications

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“…There was a marked decrease in the levels of serum TG, TC, HDL-C, and an increase in LDL-C in NAFLD when compared to healthy control animals (Huang, Tung, Hsia, Wu, & Yen, 2017;Wang, Li, et al, 2014). Supplementation of the nutrient mixture to NAFLD rats led to an increase in serum TG, TC, HDL-C, and a decrease in serum LDL-C levels, indicating the nutrient mixture's anti-steatotic effects, which has been established in earlier studies (Nithyananthan et al, 2020). Studies have revealed that V. radiata regulates the growth of gut microbiota and decreases the absorption of toxic substances through the intestine and also reduces the risk of development of hypercholesterolemia and cardiovascular disease (Kruawan, 2012).…”

Section: F I G U R E 8 (A)supporting

confidence: 72%

“…It is also a rich source of carbohydrate (22%-45%) (Benítez et al, 2013). The prepared medicinal value-enriched nutritional mixture has increased antioxidants, nutritional value, reduced anti-nutritional value, and also has reduced CCl 4 -induced liver cirrhosis (Nithyananthan et al, 2020). The reduced anti-nutritional value of this nutrient mixture could be due to the effective food processing procedure like germination and dehulling (Coulibaly, Kouakou, & Chen, 2011;Oghbaei & Prakash, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…The nutrient mixtures were made with the germinated horse gram and green gram whose medicinal values were improved with fenugreek and turmeric to target various stages of NASH progression.. In the first phase of our study, we found that newly made herbal nutritional mixture has rich nutrition factors with reduced anti‐nutritional factors and also prevented CCl 4 ‐induced liver cirrhosis (Nithyananthan et al, ). In the current investigation, we intended to evaluate the therapeutic application of nutrient mixture against NAFLD and its preventive effect on the progression of steatohepatitis from hepatic steatosis.…”

Section: Introductionmentioning

confidence: 87%

“…The nutrient herbal mixture was prepared as explained in Nithyananthan et al (2020). In crisp, the germinated seeds were manually dehulled, dried under the shade at room temperature (RT) further milled into fine powders (Oghbaei & Prakash, 2017).…”

Section: Mixture Preparationmentioning

confidence: 99%

“…After a week of quarantine period and acclimatization, the animals were randomly allocated into eight groups (n = 6). Volume and concentration of the herbal nutrient mixture were arrived through previous research articles (Nithyananthan et al, 2020;Senadheera, Ekanayake, & Wanigatunge, 2014). Group II: Animals were administered with freshly prepared nutrient herbal mixture (8 ml/kg body weight, orally) on every morning between 9:30 and 10:30 a.m. for 4 weeks.…”

Section: Animal Studiesmentioning

confidence: 99%

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Curcuma longaandTrigonella foenum graecum‐enriched nutrient mixture from germinatedMacrotyloma uniflorumandVigna radiateameliorate nonalcoholic fatty liver diseases in rats

et al. 2020

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The prevalence of nonalcoholic fatty liver is increasing due to modern lifestyle. Germinated and dehulled Macrotyloma uniflorum and Vigna radiate were shown to have enhanced nutrients. Curcuma longa and Trigonella foenum graecum were proven hepatoprotective.The supplementation of the nutrient herbal mixture to the MCD diet‐induced steatosis shows reduced hepatic fat accumulation and lipid profile, and liver injury markers in serum also reserved in normal. Increased serum albumin in the treatment group indicates that the liver function is enhanced than that of steatosis. The supplementation of the herbal mixture has preserved the hepatic antioxidant. Zymographic analysis of matrix metalloproteinase, western blot determination of α‐SMA, and histological evolution (H&E, Sirius red) depicted reduced fibrosis and reveled management of hepatic stellate cells in quiescent form. The present study concludes that the herbal mixture has reduced hepatocyte fat accumulation in steatotic animals, and curtailed the oxidative stress, further it prevents the progression of steatohepatitis. Practical applications Fatty liver diseases can be treated by modulating the diet composition such as consuming food rich in the nutrient herbal mixture. In this study, the nutrient mixture was made with dynamic food processing techniques such as germination, dehulling, and milling to augment the nutritional contents. Besides, Macrotyloma uniflorum, Vigna radiate, Curcuma longa, and Trigonella foenum graecum were used to improve the medicinal value and antioxidant. This formulation could target the various stages of NAFLD. This study revealed that the nutrient herbal mixture reduces the steatosis of the liver and curtailed the progression of steatohepatitis from hepatic steatosis. Since the edible foodstuff was used to make the nutrient mixture, it has excellent clinical application.

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Section: F I G U R E 8 (A)supporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 87%

Section: Mixture Preparationmentioning

confidence: 99%

Section: Animal Studiesmentioning

confidence: 99%

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Curcuma longaandTrigonella foenum graecum‐enriched nutrient mixture from germinatedMacrotyloma uniflorumandVigna radiateameliorate nonalcoholic fatty liver diseases in rats

et al. 2020

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Values of natural products to future antiinflammatory pharmaceutical discovery

Amalraj¹,

Gopi²

2021

Inflammation and Natural Products

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Mechanisms of main components in Curcuma longa L. on hepatic fibrosis based on network pharmacology and molecular docking: A review

Han¹,

Zhu

Zhang

2023

Medicine

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Background: Hepatic fibrosis is a great concern in public health. While effective drugs for its treatment are lacking, Curcuma longa L. (CL) has been reported as a promising therapeutic. We aimed to uncover the core components and mechanisms of CL against hepatic fibrosis via a network pharmacology approach. Methods: The main components of CL were obtained and screened. While targets of components and disease were respectively collected using SwissTargetPrediction and online databases, common targets were assessed. A protein–protein interaction (PPI) network was constructed, and core targets were identified. GO and KEGG pathway enrichment analyses were performed, and molecular docking was conducted to validate the binding of core components in CL on predicted core targets. Results: Nine main components from CL based on high-performance liquid chromatography (HPLC) and 63 anti-fibrosis targets were identified, and a PPI network and a component target-disease target network were constructed. Apigenin, quercetin, demethoxycurcumin, and curcumin are likely to become key phenolic-based components and curcuminoids for the treatment of hepatic fibrosis, respectively. KEGG pathway enrichment analysis revealed that the HIF-1 signaling pathway (hsa04066) was most significantly enriched. Considering core targets of the PPI network and a network of the common targets and pathways enriched, AKT1, MAPK1, EGFR, MTOR, and SRC may be the core potential targets of CL against hepatic fibrosis. Molecular docking was carried out to verify the binding of above core components to core targets. Conclusions: The therapeutic effect of CL on hepatic fibrosis may be attributed to multi-components, multi-targets, and multi-pathways.

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Nutrient mixture from germinated legumes: Enhanced medicinal value with herbs‐attenuated liver cirrhosis

Cited by 3 publications

References 45 publications

Curcuma longaandTrigonella foenum graecum‐enriched nutrient mixture from germinatedMacrotyloma uniflorumandVigna radiateameliorate nonalcoholic fatty liver diseases in rats

Curcuma longaandTrigonella foenum graecum‐enriched nutrient mixture from germinatedMacrotyloma uniflorumandVigna radiateameliorate nonalcoholic fatty liver diseases in rats

Values of natural products to future antiinflammatory pharmaceutical discovery

Mechanisms of main components in Curcuma longa L. on hepatic fibrosis based on network pharmacology and molecular docking: A review

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