Nutrient-enriched formula versus standard term formula for preterm infants following hospital discharge

Young, Lauren; Morgan, Jessie; McCormick, Felicia; McGuire, William

doi:10.1002/14651858.cd004696.pub4

Cited by 50 publications

(52 citation statements)

References 52 publications

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“…In order to achieve catch-up growth, IUGR neonates are generally fed a formula containing a high density of nutrients [29]. However, high nutritional intake may induce oxidative stress and metabolic syndrome [30], which can be exaggerated in IUGR offspring due to their immature antioxidant defense system [26].…”

Section: Discussionmentioning

confidence: 99%

Effect of Postnatal Nutrition Restriction on the Oxidative Status of Neonates with Intrauterine Growth Restriction in a Pig Model

Che

Xuan

et al. 2014

Neonatology

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Objective: In offspring with intrauterine growth restriction (IUGR), where oxidative stress may play an important role in inducing metabolic syndrome, nutrition restriction has been shown to improve oxidative status. In this study, we aimed to investigate the effect of postnatal nutrition restriction on the oxidative status of IUGR neonates. Methods: A total of twelve pairs of piglets, of normal birth-weight (NBW) and with IUGR (7 days old), respectively, were randomly allocated to have adequate nutritional intake (ANI) and restricted nutritional intake (RNI) for a period of 21 days, respectively. This design produced 4 experimental groups: NBW-ANI, IUGR-ANI, NBW-RNI and IUGR-RNI (n = 6 per group). Serum, ileum and liver samples were analyzed for antioxidant parameters and the mRNA expression of genes with regard to oxidative status. The data were subjected to general linear model analysis and Duncan's test with a 5% significance level. Results: Irrespective of nutritional intake, the IUGR pigs had markedly lower activity of glutathione peroxidase (GP_X), gene expressions of liver mitochondrial manganese superoxide dismutase (Mn-SOD) and ileum cytoplasmic copper/zinc (CuZn)-SOD and, accordingly, there was a markedly higher malondialdehyde concentration in the liver of these pigs compared to in the NBW pigs. Irrespective of body weight, pigs receiving ANI treatment had significantly lower activities of antioxidant enzymes in the serum (total antioxidative capability, CuZn-SOD and GP_X) and liver (total SOD and glutathione reductase) and decreased gene expression of liver CuZn-SOD and Mn-SOD compared to the pigs receiving RNI. In addition, the IUGR pigs had a markedly lower concentration of liver reduced glutathione (GSH), ratio of GSH to oxidized glutathione, gene expression of ileum CuZn-SOD and extracellular SOD than the NBW pigs when receiving ANI, but not all of these differences were observed in those receiving RNI. Conclusion: IUGR neonates may have poor antioxidant defense systems, and postnatal nutrition restriction has the potential to prevent oxidative stress. © 2014 S. Karger AG, Basel

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Section: Discussionmentioning

confidence: 99%

Effect of Postnatal Nutrition Restriction on the Oxidative Status of Neonates with Intrauterine Growth Restriction in a Pig Model

Che

Xuan

et al. 2014

Neonatology

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“…Weight and Ht, before 2 years of age measured in horizontal position, were recorded monthly 1 year after full-term age (termed as 1 year of age throughout the text), three-monthly until 2 years and thereafter yearly. HC was measured monthly from full-term age until 1 year of age, at 15 months and at median age of 8.1 years in boys and 9.7 years in girls (range [2][3][4][5][6][7][8][9][10][11][12][13][14]. Infants were considered full term at 40 weeks corrected age.…”

Section: Data Collection and Processingmentioning

confidence: 99%

“…Ht and Wt data were available for 72% of the boys and 82% of the girls at term; more than 90% of the children at 1 and 2 years of age and 70% of the boys and 72% of the girls at 10 years of age. HC data were available for 72% of the children at term, 77% of them at 15 months and for 51% at the study visit (mean age of 8 years; range [3][4][5][6][7][8][9][10][11][12][13][14]. Data distribution for Wt after full term was generally positively skewed in girls but normally distributed in boys.…”

Section: Data Qualitymentioning

confidence: 99%

Growth charts and long‐term sequelae in extreme preterm infants – from full‐term age to 10 years

et al. 2013

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“…Adequate nutrition is important to optimize catch-up growth. A review showed that current recommendations to prescribe nutrient-enriched formula for preterm infants following hospital discharge are not supported by the available evidence [40]. Currently, post-discharge feeding (formula) is given to stimulate growth, but it is still unknown if this stimulates unhealthy catch-up growth.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Early Catch-Up Growth on Health and Well-Being in Young Adults

Dommelen¹,

Pal²,

Gravenhorst³

et al. 2014

Ann Nutr Metab

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Aim: To study the effect of catch-up growth in the 1st year on cognition, health-related quality of life (HRQoL), problem behavior and growth in young adults. Methods: We included individuals without severe complications and born small for gestational age (SGA; n = 228 for weight, n = 203 for length) or with a low head circumference (HC, n = 178) or a low weight adjusted for length (n = 64) in the Collaborative Project on Preterm and SGA Infants. Neonatal growth was standardized (standard deviation scores for gestational age, SDS_GA) according to GA-specific reference charts. Catch-up growth was defined as SDS_GA at 1 year of age adjusted for SDS_GA at birth. Cognition was defined by the Multicultural Capacity Test-Intermediate Level, HRQoL by the London Handicap Scale (LHS) and the Health Utility Index Mark 3 categorized into 4 levels (Multi-Attribute Utility, MAU), and problem behavior by the Young Adult Self-Report. We adjusted for potential confounders. Results: Most adults were born preterm (93.7%). A higher catch-up growth in the 1st year was associated with better cognition (B = 2.57, 95% CI 0.08-5.05 for weight), less disabilities according to the LHS (B = 2.06, 95% CI 0.35-3.78 for HC) and the MAU (OR = 0.67, 95% CI 0.48-0.95 for HC) and higher final height (B = 0.33, 95% CI 0.18-0.47 for weight; B = 0.41, 95% 0.28-0.55 for length, and B = 0.18, 95% CI 0.04-0.33 for HC) in young adulthood. Conclusion: There are long-term benefits of catch-up growth.

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Nutrient-enriched formula versus standard term formula for preterm infants following hospital discharge

Cited by 50 publications

References 52 publications

Effect of Postnatal Nutrition Restriction on the Oxidative Status of Neonates with Intrauterine Growth Restriction in a Pig Model

Effect of Postnatal Nutrition Restriction on the Oxidative Status of Neonates with Intrauterine Growth Restriction in a Pig Model

Growth charts and long‐term sequelae in extreme preterm infants – from full‐term age to 10 years

The Effect of Early Catch-Up Growth on Health and Well-Being in Young Adults

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