Nutrient Effects on DNA and Chromatin Structure

Zinc deficiency induces production of the proinflammatory cytokines IL-1β and TNFα in promyeloid cells via epigenetic and redox-dependent mechanisms

“…In primary monocytes, PMA stimulation activates NOX-mediated ROS production [35,40]. NOX is also involved in the PMA-induced production of ROS by HL-60 def , and NOX-produced ROS are important for IL-1β and TNFα production (Fig.…”

“…Because zinc is involved in epigenetic processes such as chromatin remodeling [11][12][13]35], we compared the chromatin structures of IL-1β and TNFα promoters in HL-60 def and HL-60 suf . Accessibilities of promoter regions IL-1β I (− 107 to − 17), IL-1β II (−199 to −109) (Fig.…”

A fully integrated new paradigm for lithium’s mode of action – lithium utilizes latent cellular fail-safe mechanisms

“…PARP-1 and Mg ++ both help to maintain chromatin structure. 138 , 139 PARP1, in turn, induces ADP ribosylation of GAPDH – an enzyme that consumes NAD+, leading to its utilization – inactivation (not just a change in redox state) and an accumulation of glycolytic metabolites earlier in the pathway (which could have effects on minor sugar phosphate levels). PARP-1 activity is known to induce NO production.…”

Η Επιδραση Στην Ερυθροκυτταρικη Διακινηση Του Ψευδαργυρου (Zn) Βιολογικα Δραστικων Παραγοντων

“…Ο Ζη εκκρίνεται από την γαστρεντερική οδό. Στις παγκρεατικές εκκρίσεις βρέθηκαν 2-5 mg/μέρα (Endre, L, et al, 1990), (Castro, CE., 1987). Η απώλεια από τα ούρα κυμαίνεται στα επίπεδα των 500-800 μg/μέpα και κυρίως οφείλεται στις εκκρίσεις από το εγγύς εσπειραμένο σωληνάριο (Abu-Hamdan, D., et al, 1981).…”