Nutrient-Drug Interactions

Hathcock, John N.

doi:10.1016/s0749-0690(18)30812-7

Cited by 15 publications

(5 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presmt study pointed to an interesting difference between malnounshed and non-malnounshed pahents regarding drug consumption patterns The use of diuretics in the malnounshed group could be m agreement with a tendency for oedema formation as a consequence of a lowered osmotic pressure or immobilization Drugs can affect nutrient intake, function and requirement (Hathcock 1987) The malnounshed patients with insufficient food mtake used more diuretics than the non-malnounshed Assoaahon between the use of diuretics and anorexia in genatnc patients has been discussed with some uncertainty (Roe 1977) Regarding the increased use of analgesics in the non-malnounshed group, this could be m accordance with a positive impact of pam relief on the nutritional status of elderly people…”

Section: Discussionmentioning

confidence: 87%

“…Malnutrition has been recognized as a common problem among newly admitted (Bienia et al 1982, Larsson ei al 1990a and hospitalized elderly patients (Asplund el al 1981, Sandman el al 1987 This condition is assoaated with an increased morbidity and mortality (Bienia et al 1982) Likewise, nutritional detenorahon occurs dunng hospitahzahon (Larsson et al 1990a, Sandman et al 1987 Nutritional state is a process of lngeshon, digestion, absorption, transportation, utilization and excretion of nutrients Among the elderly living at home, nutntional surveys of dietary intake have recognized physical and mental disorders (Stanton & Exton-Smith 1970, Exton-Smith et al 1972, hving arrangements, mcome (Davis et al 1985), education (Steen et al 1977), soaal anchorage and social support (Hanson et al 1987, Mclntosh el al 1989 as factors influencing dietary intake Elderly people are frequent consumers of drugs (Landahl 1987) Vanous drug-nutnent interactions can influence different parts of the nutntional process (Roe 1977, Hathcock 1987 The identification of charactenstics as factors for protein-energy malnutntion m genatnc hospitalized patients, soon after admission, is important for prevention and treatment Most of the surveys which have been made to identify nsk factors for malnutntion have been on the basis of dietary intake and elderly people livmg at home No studies have been found which directly compare malnounshed and non-malnounshed patients on admission to the long-term care cliruc…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Demographical, sociomedical and physical characteristics in relation to malnutrition in geriatric patients

Unosson¹,

Ac²,

Bjurulf

et al. 1991

Journal of Advanced Nursing

View full text Add to dashboard Cite

The purpose of this study was to describe and compare demographical, sociomedical and physical characteristics between protein-energy malnourished and non-malnourished geriatric patients on admission. According to the International Statistical Classification of Diseases, 104 malnourished patients were age-, gender- and diagnosis-matched with 104 non-malnourished patients. Data were collected from patients' medical records. The patient's condition was assessed by a modified Norton scale on admission. No differences were seen in marital status, type of dwelling, previous need for help service, residence before admission, and dependence on assistance with ADL function. The malnourished patients had a greater consumption of diuretics (47%; P less than 0.05) and a lower consumption of analgesics (29%; P less than 0.05) than the non-malnourished patients (33% and 42% respectively). In the malnourished group, impaired conditions in activity (83%; P less than 0.05), and general physical condition (78%; P less than 0.01) were observed compared to the non-malnourished group (69% and 60% respectively). The malnourished patients had less sufficient food intake (41% vs 21%; P less than 0.01) and fluid intake (25% vs 10%; P less than 0.01) than non-malnourished patients. This study indicates that demographical characteristics and primary ADL-functions are of minor importance for the development of protein-energy malnutrition in geriatric patients. Observation of the patients' physical condition and drug consumption seemed more important on admission.

show abstract

Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Demographical, sociomedical and physical characteristics in relation to malnutrition in geriatric patients

Unosson¹,

Ac²,

Bjurulf

et al. 1991

Journal of Advanced Nursing

View full text Add to dashboard Cite

show abstract

“…Multiple long-term use of prescribed medicine was also highly correlated with risk score. Multiple medications most likely reflect poor health and can affect one's appetite, nutrient absorption and metabolism 24 . Among the nutritional factors, the intake frequency of fruits and vegetables showed the highest correlation with the total risk score (r ¼ 0.353).…”

Section: Prevalence Of Nutritional Risksmentioning

confidence: 99%

Assessment of the nutritional risk of > 53-year-old men and women in Taiwan

Tsai

Chang

Lin

et al. 2004

Public Health Nutr.

View full text Add to dashboard Cite

Objective: The study was conducted to gain an understanding of the status of potential nutrition risks in . 53-year-old men and women in Taiwan. Methods: The study employed a validated nutrition-risk screening questionnaire, the Mini Nutritional Assessment, to assess the potential risk of undernutrition in the elderly population in Taiwan. The questionnaire was translated into the local language, Chinese, and was modified slightly based on cultural considerations. It was administered to 4440 randomly selected subjects by means of face-to-face interviews. The questionnaire included questions on subjective self-evaluations, global parameters, simple dietary assessment and some anthropometric measurements. Results: Results show that the questionnaire can be used effectively as a tool to screen for individuals who are at risk of undernutrition. It showed that the proportion of the elderly population at risk of nutritional inadequacy is relatively low, but does increase with advanced ageing. The proportion of the elderly considered at high risk of undernutrition was found to increase with age, ranging from 0.88% for 53 -60-yearold subjects to 1.86% for subjects aged 60 -70 years, 3.6% for 70 -80-year-olds and 5.3% for . 80-year-old subjects. Conclusion:The study showed that a simple questionnaire adopted from the Mini Nutritional Assessment can be employed to provide a preliminary screening and to identify individuals who are potentially at increased risk of nutritional inadequacy in the elderly population in Taiwan.

show abstract

“…Hathcock (35,63) has reviewed the literature concerning the effect of minerals on drug metabolism. It has been shown that iron levels in the liver are rather stable during deficiency, and that dietary iron deprivation increases some MFOS activities and decreases other degradative functions.…”

Section: Mineralsmentioning

confidence: 99%

“…The effects of selenium deficiency on MFOS activities are contradictory and inconsistent. Zinc, iodine, magnesium, and potassium deficiencies have reportedly been shown to decrease drug oxidation and drug clearance (35,63).…”

Section: Mineralsmentioning

confidence: 99%

The influence of food on the absorption and metabolism of drugs: an update

Williams

Hill

Davis

et al. 1996

European Journal of Drug Metabolism and Pharmacokinetics

View full text Add to dashboard Cite

Food-drug interactions can lead to a loss of therapeutic efficacy or toxic effects of drug therapy. Generally, the effect of food on drugs results in a reduction in the drug's bioavailability; however, food can also alter drug clearance. The benefits of considering metabolism and pharmacokinetic information in the drug discovery process have been highlighted by Humphrey and Smith (79) and the process of rational drug design should include considerations of the chemistry, pharmacology and pharmacokinetics of the drug (80) and the impact of diet on these parameters.

show abstract

Nutrient-Drug Interactions

Cited by 15 publications

References 15 publications

Demographical, sociomedical and physical characteristics in relation to malnutrition in geriatric patients

Demographical, sociomedical and physical characteristics in relation to malnutrition in geriatric patients

Assessment of the nutritional risk of > 53-year-old men and women in Taiwan

The influence of food on the absorption and metabolism of drugs: an update

Contact Info

Product

Resources

About