Tempeh gembus is a traditional Indonesian prepared from solid tofu waste fermented by Rhizopus oligosporus. It contained some nutritional value and bioactives from fermentation, making tempeh gembus a functional food with variety of health benefits. Previous research had investigated functional properties of tempeh gembus, such as amidolytic, antimicrobial, and antioxidant, as well as proteolytic, fibrinolytic, fibrinogenolytic, and anti-inflammation, which were linked to a variety health benefits, including atherosclerosis, diabetes mellitus, hyperlipidaemia, obesity, metabolic syndrome, and osteopenia. Tempeh gembus is sometimes underestimated because it is prepared from tofu waste and is frequently consumed by low-income people due to its low cost. Tempeh gembus intake is also low due to a lack of knowledge about its health benefits. This article reviews the health benefits of tempeh gembus as one of Indonesia's local functional foods.