Nutrient availability contributes to a graded refractory period for regeneration in Xenopus tropicalis

Williams, Madison C; Patel, Jeet H.; Kakebeen, Anneke Dixie; Wills, Andrea E.

doi:10.1016/j.ydbio.2021.01.005

Cited by 17 publications

(14 citation statements)

References 53 publications

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“…The treatments across species were not exactly identical, and correspondingly there might be differences in the precise molecular mechanisms—in spite of which they could be applied across species in a predictive manner. In line with our findings, the role of nutrients in promoting regeneration was reported in yet another species (in the Xenopus tadpoles , Williams et al, 2021 ). While the observed regenerative response is not perfect, this motivates further investigation into potentially more promoting factors or the possibility of combining broad promoting factors with species- or tissue-specific morphogenetic regulators.…”

Section: Discussionsupporting

confidence: 93%

A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice

Abrams

Tan

et al. 2021

eLife

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Can limb regeneration be induced? Few have pursued this question, and an evolutionarily conserved strategy has yet to emerge. This study reports a strategy for inducing regenerative response in appendages, which works across three species that span the animal phylogeny. In Cnidaria, the frequency of appendage regeneration in the moon jellyfish Aurelia was increased by feeding with the amino acid L-leucine and the growth hormone insulin. In insects, the same strategy induced tibia regeneration in adult Drosophila. Finally, in mammals, L-leucine and sucrose administration induced digit regeneration in adult mice, including dramatically from mid-phalangeal amputation. The conserved effect of L-leucine and insulin/sugar suggests a key role for energetic parameters in regeneration induction. The simplicity by which nutrient supplementation can induce appendage regeneration provides a testable hypothesis across animals.

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Section: Discussionsupporting

confidence: 93%

A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice

Abrams

Tan

et al. 2021

eLife

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“…Alternatively, extrinsic signals might be involved. Nutrient availability was recently proposed as a contributor of tail regenerative competence in X. tropicalis [ 29 ]. In this species, as previously observed in X. laevis , the authors identified a refractory period where tail regeneration is hampered and showed that it can be circumvented by alleviating nutrient stress.…”

Section: Discussionmentioning

confidence: 99%

CRISPR/Cas9-Mediated Models of Retinitis Pigmentosa Reveal Differential Proliferative Response of Müller Cells between Xenopus laevis and Xenopus tropicalis

Parain

Lourdel

Donval

et al. 2022

Cells

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Retinitis pigmentosa is an inherited retinal dystrophy that ultimately leads to blindness due to the progressive degeneration of rod photoreceptors and the subsequent non-cell autonomous death of cones. Rhodopsin is the most frequently mutated gene in this disease. We here developed rhodopsin gene editing-based models of retinitis pigmentosa in two Xenopus species, Xenopus laevis and Xenopus tropicalis, by using CRISPR/Cas9 technology. In both of them, loss of rhodopsin function results in massive rod cell degeneration characterized by progressive shortening of outer segments and occasional cell death. This is followed by cone morphology deterioration. Despite these apparently similar degenerative environments, we found that Müller glial cells behave differently in Xenopus laevis and Xenopus tropicalis. While a significant proportion of Müller cells re-enter into the cell cycle in Xenopus laevis, their proliferation remains extremely limited in Xenopus tropicalis. This work thus reveals divergent responses to retinal injury in closely related species. These models should help in the future to deepen our understanding of the mechanisms that have shaped regeneration during evolution, with tremendous differences across vertebrates.

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“…59,60 In addition, the stasis period in morphogenesis matches the refractory period for regeneration in Xenopus tropicalis. 61 These studies specifically focused on the regulation of cell proliferation by mTOR. 62,63 We observed the dynamic transition in cell proliferation during thyroid follicle morphogenesis, and mTOR may also regulate these processes, especially for feeding-dependent reactivation of cell proliferation in the later phase of follicle formation.…”

Section: Discussionmentioning

confidence: 99%

Nutritional control of thyroid morphogenesis through gastrointestinal hormones

et al. 2022

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Nutrient availability contributes to a graded refractory period for regeneration in Xenopus tropicalis

Cited by 17 publications

References 53 publications

A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice

A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice

CRISPR/Cas9-Mediated Models of Retinitis Pigmentosa Reveal Differential Proliferative Response of Müller Cells between Xenopus laevis and Xenopus tropicalis

Nutritional control of thyroid morphogenesis through gastrointestinal hormones

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