Nutrient Abundance Signals the Changing of the Seasons by Phosphorylating PER2
Daniel C. Levine,
Rasmus H. Reeh,
Thomas McMahon
et al.
Abstract:The circadian clock synchronizes metabolic and behavioral cycles with the rotation of the Earth by integrating environmental cues, such as light. Nutrient content also regulates the clock, though how and why this environmental signal affects the clock remains incompletely understood. Here, we elucidate a role for nutrient in regulating circadian alignment to seasonal photoperiods. High fat diet (HFD) promoted entrainment to a summer light cycle and inhibited entrainment to a winter light cycle by phosphorylati… Show more
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