Nutrient absorption

Nutting, David F.; Kumar, N. Suresh; Siddiqi, Shadab A.; Mansbach, Charles M.

doi:10.1097/00001574-200203000-00003

Cited by 7 publications

(4 citation statements)

References 39 publications

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“…It has been suggested that this reflects the importance of the early nutritional environment in stimulating gene expression, clonal selection or differential proliferation of cells, with permanent consequences for the quantities of cell populations in tissues (Barker 1998;Lucas 1998). The uptake and transportation of lipophilic antioxidants is dependent on lipoproteins, the formation of which in neonatal enterocytes has recently been found to be influenced by early nutritional quality (Nutting et al 2002). A putative explanation for our results is that formation of such lipoproteins was reduced in neonates on lower-quality diets, thus impairing the capacity for uptake and transport of lipophilic antioxidants.…”

Section: Discussionmentioning

confidence: 46%

Neonatal nutrition, adult antioxidant defences and sexual attractiveness in the zebra finch

Blount

Metcalfe

Arnold

et al. 2003

Proc. R. Soc. Lond. B

185

162

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Early nutrition has recently been shown to have pervasive, downstream effects on adult life-history parameters including lifespan, but the underlying mechanisms remain poorly understood. Damage to biomolecules caused by oxidants, such as free radicals generated during metabolic processes, is widely recognized as a key contributor to somatic degeneration and the rate of ageing. Lipophilic antioxidants (carotenoids, vitamins A and E) are an important component of vertebrate defences against such damage. By using an avian model, we show here that independent of later nutrition, individuals experiencing a short period of low-quality nutrition during the nestling period had a twofold reduction in plasma levels of these antioxidants at adulthood. We found no effects on adult external morphology or sexual attractiveness: in matechoice trials females did not discriminate between adult males that had received standard-or lower-quality diet as neonates. Our results suggest low-quality neonatal nutrition resulted in a long-term impairment in the capacity to assimilate dietary antioxidants, thereby setting up a need to trade off the requirement for antioxidant activity against the need to maintain morphological development and sexual attractiveness. Such state-dependent trade-offs could underpin the link between early nutrition and senescence.

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Section: Discussionmentioning

confidence: 46%

Neonatal nutrition, adult antioxidant defences and sexual attractiveness in the zebra finch

Blount

Metcalfe

Arnold

et al. 2003

Proc. R. Soc. Lond. B

185

162

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“…A recent study on captive zebra finches showed that chicks fed with poor-quality food during their first weeks of life have lower blood levels of antioxidant molecules (i.e., vitamin A, vitamin E and carotenoids) when becoming adults, compared to chicks fed with a standard diet (Blount et al 2003). These results were explained as the consequence of differences in diet composition (i.e., proportion of protein and antioxidants), which would have affected the synthesis of lipoproteins necessary for the uptake and carrying of lipophilic antioxidants (i.e., Nutting et al 2002). This explanation could also apply to the results reported in our study.…”

Section: Discussionmentioning

confidence: 99%

An Experimental Manipulation of Life-History Trajectories and Resistance to Oxidative Stress

Alonso‐Álvarez¹,

Bertrand²,

Devevey

et al. 2006

Evol

131

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“…2003). Poor nutrition during the critical neonatal period when cell populations are being established can permanently reduce numbers of lipoproteins (Nutting et al . 2002), cells responsible for the uptake and transportation of lipophilic antioxidants (Surai 2002).…”

Section: Discussionmentioning

confidence: 99%

“…We have previously shown that poor neonatal nutrition results in markedly reduced antioxidant defences in adulthood in this species (Blount et al 2003). Poor nutrition during the critical neonatal period when cell populations are being established can permanently reduce numbers of lipoproteins (Nutting et al 2002), cells responsible for the uptake and transportation of lipophilic antioxidants (Surai 2002). It is therefore likely that LQ birds were constrained in their ability to accumulate antioxidants required for reproduction.…”

Section: Discussionmentioning

confidence: 99%

Effects of neonatal nutrition on adult reproduction in a passerine bird

Blount

Metcalfe

Arnold

et al. 2006

Ibis

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Effects of neonatal nutrition on adult reproductive performance have been little studied. In Zebra Finches Taeniopygia guttata, poor neonatal nutrition is known to be associated with reduced blood antioxidant levels in adulthood, which could impair reproductive performance. Here, we compare the effects of standard‐quality (SQ) or lower‐quality (LQ) neonatal nutrition on components of fecundity. Compared with controls, LQ birds took longer to initiate egg‐laying, and then laid eggs at a slower rate. LQ birds did not, however, show reduced clutch mass or size, or yolk antioxidant levels (retinol; α‐ or γ‐tocopherol; carotenoids). Zebra Finches breed opportunistically, often only once in their short lifetime. Therefore, the timing but also the number and quality of eggs are critical fitness‐related traits. Our results indicate that LQ birds had impaired reproductive capacity, suggesting resource accumulation constraints. Maximizing egg number and quality appears to have been more important than rapid egg production.

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Nutrient absorption

Cited by 7 publications

References 39 publications

Neonatal nutrition, adult antioxidant defences and sexual attractiveness in the zebra finch

Neonatal nutrition, adult antioxidant defences and sexual attractiveness in the zebra finch

An Experimental Manipulation of Life-History Trajectories and Resistance to Oxidative Stress

Effects of neonatal nutrition on adult reproduction in a passerine bird

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