Nutriceuticals and Cardiovascular Illness

Frishman, William H.; Sinatra, Stephen T.; Kruger, Nathan

doi:10.1016/b978-0-323-03002-1.50007-0

Cited by 4 publications

(1 citation statement)

References 124 publications

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“…Vitamin C is a scavenger antioxidant and decreases peroxyl radical formation [ 96 ]. In addition to blocking lipid peroxidation by trapping peroxyl radicals in the aqueous phase, vitamin C helps to regenerate α-tocopherol from α-tocopherol radicals in membranes and lipoproteins, and also raises intracellular glutathione levels, thus playing an important role in protein thiol group protection against oxidation [ 97 ], and helps normalize endothelial vasodilator function in patients with heart failure by increasing the availability of NO [ 98 ]. High doses of vitamin C have also been associated with decreased levels of NO production by endothelial cells.…”

Section: Effects Of Nutraceuticals On Vascular Damagementioning

confidence: 99%

Natural approaches in metabolic syndrome management

Patti¹,

Al-Rasadi²,

Giglio³

et al. 2018

aoms

110

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Metabolic syndrome (MetS) is characterized as a group of cardiometabolic risk factors that raise the risk for heart disease and other health problems, such as diabetes mellitus and stroke. Treatment strategies include pharmacologic interventions and supplementary (or “alternative”) treatments. Nutraceuticals are derived from food sources (isolated nutrients, dietary supplements and herbal products) that are purported to provide health benefits, in addition to providing basic nutritional value. Nutraceuticals are claimed to prevent chronic diseases, improve health, delay the aging process, increase life expectancy, and support the structure and function of the body. The study of the beneficial effects of nutraceuticals in patients with MetS, including product standardization, duration of supplementation and definition of optimal dosing, could help better define appropriate treatment. This review focuses on widely marketed nutraceuticals (namely polyphenols, omega-3 fatty acids, macroelements and vitamins) with clinically demonstrated effects on more than one component of MetS.

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Section: Effects Of Nutraceuticals On Vascular Damagementioning

confidence: 99%

Natural approaches in metabolic syndrome management

Patti¹,

Al-Rasadi²,

Giglio³

et al. 2018

aoms

110

View full text Add to dashboard Cite

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Alternative and Complementary Medical Approaches in the Prevention and Treatment of Cardiovascular Disease

Frishman

Grattan

Mamtani

2005

Current Problems in Cardiology

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Clinical pharmacology and therapeutic use of antioxidant vitamins

Rodrigo¹,

Guichard

Charles

2007

Fundamemntal Clinical Pharma

102

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The clinical use of antioxidants has gained considerable interest during the last decade. It was suggested from epidemiological studies that diets high in fruits and vegetables might help decrease the risk of cardiovascular disease. Therefore, supplements of vitamins C and E were applied through protocols aimed to prevent diseases such as atherosclerosis, preeclampsia or hypertension, thought to be mediated by oxidative stress. Despite the biological properties of these vitamins could account for an effective protection, as shown by several clinical and experimental studies, their efficacy remains controversial in the light of some recent clinical trials and meta-analyses. However, the methodology of these studies, criteria for selection of patients, the uncertain extent of progression of the disease when initiating supplementation, the lack of mechanistic studies containing basic scientific aspects, such as the bioavailability, pharmacokinetic properties, and the nature of the antioxidant sources of vitamins, could account for the inconsistency of the various clinical trials and meta-analyses assessing the efficacy of these vitamins to prevent human diseases. This review presents a survey of the clinical use of antioxidant vitamins E and C, proposing study models based on the biological effects of these compounds likely to counteract the pathophysiological mechanisms able to explain the structural and functional organ damage.

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Nutriceuticals and Cardiovascular Illness

Cited by 4 publications

References 124 publications

Natural approaches in metabolic syndrome management

Natural approaches in metabolic syndrome management

Alternative and Complementary Medical Approaches in the Prevention and Treatment of Cardiovascular Disease

Clinical pharmacology and therapeutic use of antioxidant vitamins

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