Nutraceuticals: The New Generation Therapeutics

Ganapathy, Mathangi; Bhunia, Swati

doi:10.4172/2379-1764.1000179

Cited by 8 publications

(5 citation statements)

References 45 publications

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“…The mixture was vigorously shaken for five minutes and kept aside for 30 min and measured absobance and ascorbic acid served as the reference at 517nm. The equation used to get the inhibition ratio (%I) for all substances tested is %I=(Ac-As)/Acx100, where Ac is the absorbance of the control and As is the absorbance of the sample 27,28 .…”

Section: Biological Evaluation Dpph Radical Scavenging Assaymentioning

confidence: 99%

Design, Synthesis and Anticancer Properties of Novel Hydrazino-Fused Pyrimidines

Mittapalli,

Rizwana,

Murthy

et al. 2023

Orient. J. Chem

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The Pyrimidine system has received great attention and a vital component of genetic material emerged has fundamental source to fight against cancer. The pyrazolo(1,5-a) pyrimidines (5a-5j) were designed based on the structural features of antitumor antimetabolites, synthesized and chemical structures were confirmed using spectroscopic methods such as IR, 1H NMR, 13C NMR, Mass Spectral and elemental analysis. The cytotoxic activity was evaluated by DPPH free radical scavenging assay against standard ascorbic acid and MTT assay against MCF-7, HepG-2, and imatinib as standard. The DPPH assay indicated 5b, 5c, 5e, 5h and 5j were efficient antioxidants, while the MTT assay discloses potent cytotoxicity of 5b, 5d against MCF-7 with 16.61, 19.67µg/ml and 5c, 5h against HepG-2 with 14.32 and 19.24µg/ml compared to 5-FU. The ligands 5c and 5h demonstrated promising towards tyrosine kinase and cyclin dependent kinase 2, respectively and the bonding energy is similar as doxorubicin. Concluding that the compounds had reasonable cytotoxic potential and good association observed between in vitro and in silico studies.

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Section: Biological Evaluation Dpph Radical Scavenging Assaymentioning

confidence: 99%

Design, Synthesis and Anticancer Properties of Novel Hydrazino-Fused Pyrimidines

Mittapalli,

Rizwana,

Murthy

et al. 2023

Orient. J. Chem

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“…The connection between the use of relevant foods and health was established by the father of modern medicine, Hippocrates (460-377 BC), more than 2500 years ago, who made the statement "Let food be thy medicine and medicine be thy food" [1,3,5]. The term "Nutraceutical" originates from two broad terms such as "Nutrition" and "Pharmaceutical" [4,6,9,17,[49][50][51][52], and was coined in 1989 by Stephen DeFelice, MD, founder, and chairman of the Foundation for Innovation in Medicine (FIM), Cranford, New Jersey. According to him, the term nutraceutical is defined as "a food or a part of a food that provides medical or health benefits, including the prevention and the treatment of a disease", because in his opinion "the nutraceutical revolution will lead us into a new era of medicine and health, in which the food industry by the year 2000 will become a research-oriented one similar to the pharmaceutical industry" [45].…”

Section: Nutraceuticals 21 What Are Nutraceuticals?mentioning

confidence: 99%

“…They can be found in berries, leaves, roots, and flowers as various parts of plants that are used for medicinal purposes. The combination of herbal products with nutraceuticals can treat many chronic disorders [52][53][54]84]. Phytochemicals have become more popular as a result of the increment of studies on nutrients.…”

Section: Classification Of Nutraceuticalsmentioning

confidence: 99%

Nutraceutical Concepts and Dextrin-Based Delivery Systems

Hoti

Pedrazzo

Cecone

et al. 2022

IJMS

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Nutraceuticals are bioactive or chemical compounds acclaimed for their valuable biological activities and health-promoting effects. The global community is faced with many health concerns such as cancers, cardiovascular and neurodegenerative diseases, diabetes, arthritis, osteoporosis, etc. The effect of nutraceuticals is similar to pharmaceuticals, even though the term nutraceutical has no regulatory definition. The usage of nutraceuticals, to prevent and treat the aforementioned diseases, is limited by several features such as poor water solubility, low bioavailability, low stability, low permeability, low efficacy, etc. These downsides can be overcome by the application of the field of nanotechnology manipulating the properties and structures of materials at the nanometer scale. In this review, the linear and cyclic dextrin, formed during the enzymatic degradation of starch, are highlighted as highly promising nanomaterials- based drug delivery systems. The modified cyclic dextrin, cyclodextrin (CD)-based nanosponges (NSs), are well-known delivery systems of several nutraceuticals such as quercetin, curcumin, resveratrol, thyme essential oil, melatonin, and appear as a more advanced drug delivery system than modified linear dextrin. CD-based NSs prolong and control the nutraceuticals release, and display higher biocompatibility, stability, and solubility of poorly water-soluble nutraceuticals than the CD-inclusion complexes, or uncomplexed nutraceuticals. In addition, the well-explored CD-based NSs pathways, as drug delivery systems, are described. Although important progress is made in drug delivery, all the findings will serve as a source for the use of CD-based nanosystems for nutraceutical delivery. To sum up, our review introduces the extensive literature about the nutraceutical concepts, synthesis, characterization, and applications of the CD-based nano delivery systems that will further contribute to the nutraceutical delivery with more potent nanosystems based on linear dextrins.

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“…This study investigated the potential of five anthoxanthin polyphenols, flavone (FLA), apigenin (API), luteolin (LUT), kaempferol (KAE), and quercetin (QUE) (Figure ), as natural therapeutics for AD. These compounds have been studied as therapeutics for a variety of ailments, including osteoarthritis, inflammation, spasms, and cancer . Here, experimentation examines the ability of these anthoxanthins to attenuate A β oligomer‐induced neuronal responses associated with AD, including increases in intracellular ROS and activation of caspases.…”

Section: Introductionmentioning

confidence: 99%

Anthoxanthin Polyphenols Attenuate Aβ Oligomer‐induced Neuronal Responses Associated with Alzheimer's Disease

et al. 2016

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Aims Epidemiological evidence implicates polyphenols as potential natural therapeutics for Alzheimer's disease (AD). To investigate this prospect, five anthoxanthin polyphenols were characterized for their ability to reduce amyloid-β (Aβ) oligomer-induced neuronal responses by two mechanisms of action, modulation of oligomerization and antioxidant activity, as well as the synergy between these two mechanisms. Methods Anthoxanthin oligomerization modulation and antioxidant capabilities were evaluated and correlated with anthoxanthin attenuation of oligomer-induced intracellular reactive oxygen species (ROS) and caspase activation using human neuroblastoma cell treatments designed to isolate these mechanisms of action and to achieve dual-action. Results While modulation of oligomerization resulted in only minor reductions to neuronal responses, anthoxanthin antioxidant action significantly attenuated oligomer-induced intracellular ROS and caspase activation. Kaempferol uniquely exhibited synergism when the two mechanisms functioned in concert, leading to a pronounced reduction in both ROS and caspase activation. Conclusions Together, these findings identify the dominant mechanism by which these anthoxanthins attenuate Aβ oligomer-induced neuronal responses, elucidate their prospective synergy, and demonstrate the potential of anthoxanthin polyphenols as natural AD therapeutics.

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Nutraceuticals: The New Generation Therapeutics

Cited by 8 publications

References 45 publications

Design, Synthesis and Anticancer Properties of Novel Hydrazino-Fused Pyrimidines

Design, Synthesis and Anticancer Properties of Novel Hydrazino-Fused Pyrimidines

Nutraceutical Concepts and Dextrin-Based Delivery Systems

Anthoxanthin Polyphenols Attenuate Aβ Oligomer‐induced Neuronal Responses Associated with Alzheimer's Disease

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