Nutraceuticals in immunosenescence

Magrone, Thea; Jirillo, Emilio

doi:10.1002/9781118823408.ch5

Cited by 4 publications

(2 citation statements)

References 148 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although several reviews have postulated potential beneficial effects of polyphenols on the immune response of older adults, there have been limited studies on this topic (145). However, the major effects of polyphenols are associated with increased release of IL-2 and IFN-γ, hence enhancing immune response (146). For example, resveratrol, a polyphenol typically found in red wine, grape skins, and berries, induces a significant increase in T helper cells and in the delayed-type hypersensitivity response of aged rats (147).…”

Section: Dietary Strategies Currently Being Investigatedmentioning

confidence: 99%

Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention

et al. 2019

View full text Add to dashboard Cite

Aging is accompanied by remodeling of the immune system. With time, this leads to a decline in immune efficacy, resulting in increased vulnerability to infectious diseases, diminished responses to vaccination, and a susceptibility to age-related inflammatory diseases. An age-associated immune alteration, extensively reported in previous studies, is the reduction in the number of peripheral blood naïve cells, with a relative increase in the frequency of memory cells. These two alterations, together with inflamm-aging, are considered the hallmarks of immunosenescence. Because aging is a plastic process, it is influenced by both nutritional and pharmacological interventions. Therefore, the role of nutrition and of immunomodulation in immunosenescence is discussed, due to the multifactorial influence on these hallmarks. The close connection between nutrition, intake of bioactive nutrients and supplements, immune function, and inflammation demonstrate the key role of dietary strategies as regulators of immune response and inflammatory status, hence as possible modulators of the rate of immunosenescence. In addition, potential options for therapeutic intervention are clarified. In particular, the use of interleukin-7 as growth factor for naïve T cells, the function of checkpoint inhibitors in improving T cell responses during aging and, the potential of drugs that inhibit mitogen-activated protein kinases and their interaction with nutrient signaling pathways are discussed. Finally, it is suggested that the inclusion of appropriate combinations of toll-like receptor agonists may enhance the efficacy of vaccination in older adults.

show abstract

Section: Dietary Strategies Currently Being Investigatedmentioning

confidence: 99%

Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention

et al. 2019

View full text Add to dashboard Cite

show abstract

“…As a multi-target neuroprotective agent, ATX participates in neuroprotection through anti-inflammatory, antioxidant, and anti-apoptosis mechanisms. However, ATX’s application is limited because it has poor water solubility and could be easily absorbed by intestinal cells and degraded by light, oxygen stress, and thermal stress ( Baranska and Kaczor, 2015 ). Nanomedicine improves the pharmacokinetics, administration, and bioavailability of drugs through biodegradable nano aggregates.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective Effect of Ultrasound Triggered Astaxanthin Release Nanoparticles on Early Brain Injury After Subarachnoid Hemorrhage

Cai

Zhi

et al. 2021

Front. Chem.

View full text Add to dashboard Cite

Subarachnoid hemorrhage (SAH) is a fatal disease. Within 72 h of SAH, the intracranial blood-brain barrier (BBB) is destroyed, and the nerve cells have responses such as autophagy, apoptosis, and oxidative stress. Antioxidation is an essential treatment of SAH. Astaxanthin (ATX) induces cells’ antioxidant behaviors by regulating related signal pathways to reduce the damage of brain oxidative stress, inflammation, and apoptosis. Because of its easy degradability and low bioavailability, ATX is mainly encapsulated with stimulus-responsive nanocarriers to improve its stability, making it rapidly release in the brain and efficiently enter the lesion tissue. In this study, the ultrasonic cavitation agent perfluorocarbon (PFH), ATX, and fluorescent dye IR780 were loaded with polydopamine (PDA) to prepare a US triggered release nanoparticles (AUT NPs). The core-shell structure of AUT NPs formed a physical barrier to improve the bioavailability of ATX. AUT NPs have high ATX loading capacity and US responsiveness. The experimental results show that the AUT NPs have high stability in the physiological environment. Both US and pH stimuli can trigger the release. Under US, PFH breaks through the rigid shell. The structure of AUT NPs is destroyed in situ, releasing the loaded drugs into neuronal cells to realize the antioxidant and antiapoptotic effects. The in vivo experiment results show that the AUT NPs have good biosafety. They release the drugs in the brain under stimuli. The in vivo treatment results also show that AUT NPs have an excellent therapeutic effect. This approach presents an experimental basis for the establishment of Innovative SAH treatments.

show abstract

Bioactive food components for managing cellular senescence in aging and disease: A critical appraisal and perspectives

Sharma

2021

PharmaNutrition

View full text Add to dashboard Cite

Nutraceuticals in immunosenescence

Cited by 4 publications

References 148 publications

Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention

Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention

Neuroprotective Effect of Ultrasound Triggered Astaxanthin Release Nanoparticles on Early Brain Injury After Subarachnoid Hemorrhage

Bioactive food components for managing cellular senescence in aging and disease: A critical appraisal and perspectives

Contact Info

Product

Resources

About