“…P. tricornutum extracts, which are rich in fucoxanthin, reduced liver lipid accumulation in mice [13]. Anthocyanins or phenolic acids are nutraceutical coupounds known to exert hepatoprotective and hepatotropic effects and, associated with P. tricornutum extracts, could have greater efficicency in the prevention of fructose-induced NAFLD [77,78].…”
Long-chain polyunsaturated fatty acids, n-3 series (n-3 LC-PUFA), are known for their preventive effects against cardiovascular disease. In an unfavourable economic and environmental context of fish oil production, marine microalgae could be an alternative source of n-3 LC-PUFA and are of interest for human nutrition. The aim of this study was to evaluate the effects of P. tricornutum, a microalga rich in eicosapentaenoic acid and used as a food supplement, on the metabolic disorders associated with metabolic syndrome and obesity development. Three male Wistar rat groups (n = 6) were submitted for eight weeks to a standard diet or high-fat diet (HF) with 10% fructose in drinking water, supplemented or not with 12% of P. tricornutum (HF-Phaeo). Supplementation led to n-3 LC-PUFA enrichment of lipids in the liver, plasma and erythrocytes. Plasma transaminases showed no difference between the HF and HF-Phaeo groups. Body weight, fat mass, inflammatory markers and insulinemia decreased in HF-Phaeo rats versus the HF group. Plasma total cholesterol, triacylglycerols and leptine diminished in HF-Phaeo rats, while HDL-cholesterol increased. In conclusion, this study highlights the beneficial effects of P. tricornutum in reducing the metabolic disorders associated with metabolic syndrome.
“…P. tricornutum extracts, which are rich in fucoxanthin, reduced liver lipid accumulation in mice [13]. Anthocyanins or phenolic acids are nutraceutical coupounds known to exert hepatoprotective and hepatotropic effects and, associated with P. tricornutum extracts, could have greater efficicency in the prevention of fructose-induced NAFLD [77,78].…”
Long-chain polyunsaturated fatty acids, n-3 series (n-3 LC-PUFA), are known for their preventive effects against cardiovascular disease. In an unfavourable economic and environmental context of fish oil production, marine microalgae could be an alternative source of n-3 LC-PUFA and are of interest for human nutrition. The aim of this study was to evaluate the effects of P. tricornutum, a microalga rich in eicosapentaenoic acid and used as a food supplement, on the metabolic disorders associated with metabolic syndrome and obesity development. Three male Wistar rat groups (n = 6) were submitted for eight weeks to a standard diet or high-fat diet (HF) with 10% fructose in drinking water, supplemented or not with 12% of P. tricornutum (HF-Phaeo). Supplementation led to n-3 LC-PUFA enrichment of lipids in the liver, plasma and erythrocytes. Plasma transaminases showed no difference between the HF and HF-Phaeo groups. Body weight, fat mass, inflammatory markers and insulinemia decreased in HF-Phaeo rats versus the HF group. Plasma total cholesterol, triacylglycerols and leptine diminished in HF-Phaeo rats, while HDL-cholesterol increased. In conclusion, this study highlights the beneficial effects of P. tricornutum in reducing the metabolic disorders associated with metabolic syndrome.
“…Intoxicação medicamentosa pode levar a lesão hepática, sendo esta conhecida como DILI, do inglês Drug Induced Liver Injury. Acredita-se, que a utilização desta planta pode minimizar o DILI evitando, assim o dano hepático (1).…”
Section: Conclusãounclassified
“…Pode-se observar que as doses utilizadas nos dois estudos não alteraram a potencialidade do efeito hepatotóxico da silimarina. É sabido que alguns medicamentos utilizados para o tratamento da tuberculose causam efeitos adversos severos, principalmente para a função hepática (1). É visto que estes efeitos adversos severos contribuem para a redução da adesão ao tratamento medicamentoso.…”
Section: Conclusãounclassified
“…Outro efeito importante da silimarina é a capacidade de bloquear a ativação de NFKB (Fator Nuclear Kappa B), que reduz as citocinas inflamatórias e inibe a formação de leucotrienos, conferindo ação anti-inflamatória (1,37). Tal efeito está em concordância com os achados de Zhang e colaboradores (26) que mostraram redução de NFKB, de citocinas pró-inflamatórias e redução do acúmulo de triglicerídeos nos hepatócitos em um estudo com animais.…”
Section: Conclusãounclassified
“…bile, a metabolização dos nutrientes e a desintoxicação dos inúmeros metabólitos proveniente do metabolismo interno (1). Deste modo, os problemas hepáticos repercutem de forma negativa na saúde do indivíduo podendo causar algumas doenças hepáticas como: esteatose hepática, hepatites, cirrose, carcinoma hepatocelular.…”
As plantas medicinais têm sido utilizadas como fonte alternativa no tratamento de doenças hepáticas, cabendo destacar a Alcachofra (Cynara scolymus L.) e o Cardo mariano (Silybum marianum), que atualmente vêm apresentando evidências de efeitos hepatoprotetores. O presente artigo tem como objetivo buscar evidências científicas acerca da efetividade hepatoprotetora destas plantas. Trata-se de revisão de literatura com seleção criteriosa da produção científica das plantas medicinais mencionadas acima, os quais foram selecionados 19 artigos que preencheram os critérios estabelecidos. Para tal foram consultadas as seguintes bases de dados: Scientific Eletronic Library online (SciELO), Pubmed, Science Direct e OVID. Os resultados apontaram para escassez de estudos clínicos em relação ao efeito hepatoprotetor da Cynara scolymus frente ao dano hepático. Por outro lado, os estudos pré-clínicos e clínicos da Silybum marianum mostraram avanços em relação ao efeito anti-inflamatório. Embora a maior parte (63%) dos estudos serem experimentais, os resultados parecem promissores em relação ao efeito hepatoprotetor. Portanto, consideramos que as plantas em questão podem ser uma boa alternativa para o tratamento hepático, no entanto, existe a necessidade de mais investimento em estudos clínicos randomizado em humanos, com amostra estatisticamente significativa para melhor elucidar a utilização das mesmas frente aos danos hepáticos.
Congenital heart diseases are one of the most common multi-factorial fetal abnormalities caused by a complex of endo-and exogenous factors. It is known that mutations in xenobiotic biotransformation genes can be associated with the pathogenesis of congenital heart diseases. In the presented research, 131 children with congenital heart diseases and 101 women having children with this pathology were included in the study group. In control group, 103 healthy children and their mothers were included. Single-nucleotide polymorphisms in the xenobiotic biotransformation genes CYP1A1 (rs1048943), CYP1A2 (rs762551), GSTP1 (rs6591256, rs1871042 and rs17593068) were detected by the real-time polymerase chain reaction. Gene-gene interactions were determined using the Multifactor Dimensionality Reduction method. We obtained no difference in the frequency of CYP1A1, CYP1A2 and GSTP1 between the study and control groups. At the same time, the genetic combinations GSTP1 (rs6591256)-GSTP1 (rs1871042) and GSTP1 (rs6591256)-GSTP1 (rs1871042)-CYP1A1 (rs1048943) in women; and GSTP1 (rs1793068)-GSTP1 (rs6591256)-GSTP1 (rs1871042)-CYP1A1 (rs1048943)-CYP1A2 (rs762551) in children contribute to the pathogenesis of congenital heart diseases.
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