Nutraceuticals and Natural‐Product Derivatives for Disease Prevention

Taneja, Neetu Kumra; Singh, Amritpal; Shivaprasad, D.P.; Taneja, Pankaj; Sachdev, Divya

doi:10.1002/9781119746843.ch21

Cited by 2 publications

(2 citation statements)

References 276 publications

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“…The candidate natural product mentions were manually reviewed to arrive at a reference set mapping the 73 natural products to 3460 variations (see Table S1 ). 22 …”

Section: Methodsmentioning

confidence: 99%

An evaluation of adverse drug reactions and outcomes attributed to kratom in the US Food and Drug Administration Adverse Event Reporting System from January 2004 through September 2021

Ndungu

Taneja

et al. 2023

Clinical Translational Sci

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Kratom is a widely used Asian botanical that has gained popularity in the United States due to a perception that it can treat pain, anxiety, and opioid withdrawal symptoms. The American Kratom Association estimates 10-16 million people use kratom. Kratom-associated adverse drug reactions (ADRs) continue to be reported and raise concerns about the safety profile of kratom. However, studies are lacking that describe the overall pattern of kratom-associated adverse events and quantify the association between kratom and adverse events. ADRs reported to the US Food and Drug Administration Adverse Event Reporting System from January 2004 through September 2021 were used to address these knowledge gaps. Descriptive analysis was conducted to analyze kratom-related adverse reactions. Conservative pharmacovigilance signals based on observed-to-expected ratios with shrinkage were estimated by comparing kratom to all other natural products and drugs. Based on 489 deduplicated kratom-related ADR reports, users were young (mean age 35.5 years), and more often male (67.5%) than female patients (23.5%). Cases were predominantly reported since 2018 (94.2%). Fiftytwo disproportionate reporting signals in 17 system-organ-class categories were generated. The observed/reported number of kratom-related accidental death reports was 63-fold greater than expected. There were eight strong signals related to addiction or drug withdrawal. An excess proportion of ADR reports were about kratom-related drug complaints, toxicity to various agents, and seizures.

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“…The candidate natural product mentions were manually reviewed to arrive at a reference set mapping the 73 natural products to 3460 variations (see Table S1 ). 22 …”

Section: Methodsmentioning

confidence: 99%

An evaluation of adverse drug reactions and outcomes attributed to kratom in the US Food and Drug Administration Adverse Event Reporting System from January 2004 through September 2021

Ndungu

Taneja

et al. 2023

Clinical Translational Sci

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“…In the last decade, increased attention has been paid to healthier lifestyles and nutrition, with a net trend toward the consumption of foods and supplements rich in phytochemicals that may prevent different diseases such as cancer, diabetes, neurodegeneration, and cardiovascular system disorders, among others [1]. More recently, many studies have been focused on nutraceuticals derived from natural sources, such as plants, able to prevent and treat a wide range of pathologies and whose mechanisms are still under-investigated [2]. Amongst the several medicinal plants with beneficial effects on human health, sage species health, sage species have attracted the attention of numerous researchers because of their multiple biological properties for preserving good health and treat different diseases [3,4].…”

Section: Introductionmentioning

confidence: 99%

An Update on Recent Studies Focusing on the Antioxidant Properties of Salvia Species

Iacopetta,

Ceramella,

Scumaci

et al. 2023

Antioxidants

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Nutrition has crucial effects and a significant role in disease prevention. Recently, nutraceuticals have attracted much attention in scientific research due to their pleiotropic effects and relatively non-toxic behavior. Among the biological effects displayed by plants belonging to the Lamiaceae family, such as antibacterial, anticancer, anti-inflammatory, and anticholinesterase, sage is well known for its antioxidant properties and is a rich source of numerous compounds that are biologically active, amongst them polyphenols, with more than 160 types identified. In this review we summarized some of the significant studies published in the last decade reporting the most employed extraction methods and the different assays that are useful for establishing the antioxidant properties of some sage species. Even though the scientific literature contains plenty of data regarding the antioxidant properties of many sage species, further studies are needed in order to gain a deeper understanding of the mechanism of action and the compounds responsible for their antioxidant activity. Finally, it should be taken into account that the data on the antioxidant properties of sage extracts are often difficult to compare with each other, since a series of variables in the extraction procedures, the type of assay used, and standardization may affect the final result.

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Nutraceuticals and Natural‐Product Derivatives for Disease Prevention

Cited by 2 publications

References 276 publications

An evaluation of adverse drug reactions and outcomes attributed to kratom in the US Food and Drug Administration Adverse Event Reporting System from January 2004 through September 2021

An evaluation of adverse drug reactions and outcomes attributed to kratom in the US Food and Drug Administration Adverse Event Reporting System from January 2004 through September 2021

An Update on Recent Studies Focusing on the Antioxidant Properties of Salvia Species

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