Nutraceutical Potential of Grape (Vitis vinifera L.) Seed Oil in Oxidative Stress, Inflammation, Obesity and Metabolic Alterations

Di Pietro Fernandes, Carolina; Santana, Lidiani Figueiredo; dos Santos, Jair Rosa; Fernandes, Dayane Stéphanie; Hiane, Priscila Aiko; Pott, Arnildo; Freitas, Karine de Cássia; Bogo, Danielle; do Nascimento, Valter Aragão; Filiú, Wander Fernando de Oliveira; Asato, Marcel Arakaki; Guimarães, Rita de Cássia Avellaneda

doi:10.3390/molecules28237811

Cited by 6 publications

References 71 publications

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Mouthwash Formulas for Xerostomia and Malodour

İNAL,

YAPAR,

ERDAL

et al. 2024

Preprint

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Xerostomia also known as dry mouth is often associated with bacterial malodour and oral-dental disorders. A successful treatment must provide oral hygiene and moisten the mouth. In this study, it was aimed to prepare mouthwash formulas using essential oils (1–6%), fixed oils and carboxymethyl cellulose that can meet both requirements. Citrus bergamia fruit peel oil, Cinnamomum zeylanicum leaf oil, Vitis vinifera L. and Corylus avellana L. seed oils was used as essential and fixed oils, which were analyzed by using GC-FD/MS. The organoleptic, pH, density, viscosity, antimicrobial activity, and cytotoxicity controls were conducted on the formulas. Stability studies were conducted in a stabilization cabinet at 25°C, 60%RH for 90 days, revealing that all formulations remained stable based on organoleptic assessments, pH, and density controls. Formulations containing 2% or more cinnamon oil exhibited antimicrobial activity against all investigated mouth pathogens (S. pyogenes, S. mutans, S. mitis, S. aureus, K. pneumonia, C. albicans) while formulations with 1–6% bergamot fruit peel oil displayed limited activity, proving ineffective against S. mitis. The most and the lowest cytotoxic formulations were respectively including 6% and 1% cinnamon oil (47,25% and 7,82%) while all the others were in acceptable range against gingival fibroblast cells. In conclusion, the formulation, comprising 2% cinnamon leaf oil, 2–4% hazelnut oil, and a 0.5% CMC solution, demonstrated successful physicochemical characterization with antimicrobial efficacy against all investigated mouth pathogens and exhibited acceptable safety in terms of cytotoxicity. This formulation holds promise for local treatment of xerostomia, malodor, and orodental infections.

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Mouthwash Formulas for Xerostomia and Malodour

İNAL,

YAPAR,

ERDAL

et al. 2024

Preprint

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Phytochemical and Biological Evaluation of a Newly Designed Vitis Vinifera Seed Oil Self-Nanoemulsifying System

Eid,

Issa,

safadi

et al. 2024

Preprint

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Background The objective of this research is to extract and formulate a nanoemulsion consisting of Vitis vinifera (V. vinifera) oil. Following this, the antioxidant, anti-diabetic, and anti-lipase properties of both the oil and the nanoemulsion system will be examined. Method V. vinfera seed oil extraction was followed by the preparation of its self-nanoemulsifying system. GC analysis was conducted to analyze phytochemical compounds, and physical characterization was performed for the V. vinfera oil self-nanoemulsifying system. Subsequently, antioxidant, anti-diabetic, and anti-lipase activities were investigated for the oil and its nanoemulsion. Result The biologically active components of V. vinifera oil were detected using a GC/MS device. The main components were: linoleic acid methyl ester, oleic acid methyl ester, palmitic acid methyl ester, and stearic acid methyl ester, and elaidic acid methyl ester. The optimum nanoemulsion formulation, which comprised Tween 80, Span 80, and V. vinifera seed oil and had a PDI of 0.227 ± 0.07 and a droplet size of 192.71 ± 1.8 nm. Porcine lipase inhibition of V. vinifera oil and its nanoemulsion was detected; the oil showed potent lipase inhibitory activity when compared to orlistat. The self-nanoemulsion has less inhibitory activity than the oil, with an IC50 equivalent to 13.8 ± 1.5 µg/ml. Also, V. vinifera oil inhibited a-amylase with a weak IC50 value of 257.03 ± 2.4 µg/ml. The free radical scavenging activity of the extracted V. vinifera oil was estimated using the DPPH radical method and trolox. The self-nanoemulsion has less inhibitory activity than the oil, with an IC50 value of 13.80 ± 1.5 µg/ml. Conclusion This study demonstrated the importance of black grape (V. vinfera) oil for treating and preventing obesity, diabetes, and oxidative stress, as well as how nanoemulsions improve these activities. Therefore, this natural oil is a promising product for the pharmaceutical industry.

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Polyphenol-based polymer nanoparticles for inhibiting amyloid protein aggregation: recent advances and perspectives

Fang,

Zhang,

Liu

et al. 2024

Front. Nutr.

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Polyphenols are a group of naturally occurring compounds that possess a range of biological properties capable of potentially mitigating or preventing the progression of age-related cognitive decline and Alzheimer’s disease (AD). AD is a chronic neurodegenerative disease known as one of the fast-growing diseases, especially in the elderly population. Moreover, as the primary etiology of dementia, it poses challenges for both familial and societal structures, while also imposing a significant economic strain. There is currently no pharmacological intervention that has demonstrated efficacy in treating AD. While polyphenols have exhibited potential in inhibiting the pathological hallmarks of AD, their limited bioavailability poses a significant challenge in their therapeutic application. Furthermore, in order to address the therapeutic constraints, several polymer nanoparticles are being explored as improved therapeutic delivery systems to optimize the pharmacokinetic characteristics of polyphenols. Polymer nanoparticles have demonstrated advantageous characteristics in facilitating the delivery of polyphenols across the blood–brain barrier, resulting in their efficient distribution within the brain. This review focuses on amyloid-related diseases and the role of polyphenols in them, in addition to discussing the anti-amyloid effects and applications of polyphenol-based polymer nanoparticles.

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Nutraceutical Potential of Grape (Vitis vinifera L.) Seed Oil in Oxidative Stress, Inflammation, Obesity and Metabolic Alterations

Cited by 6 publications

References 71 publications

Mouthwash Formulas for Xerostomia and Malodour

Mouthwash Formulas for Xerostomia and Malodour

Phytochemical and Biological Evaluation of a Newly Designed Vitis Vinifera Seed Oil Self-Nanoemulsifying System

Polyphenol-based polymer nanoparticles for inhibiting amyloid protein aggregation: recent advances and perspectives

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