Nutraceutical potential of Aerva lanata (L.) Juss. ex Schult ameliorates secondary complications in streptozotocin-induced diabetic rats

Riya, Mariam Philip; Antu, Kalathookunnel Antony; Pal, Subhashis; Srivastava, Ankita; Sharma, Satish Kumar; Raghu, Kozhiparambil Gopalan

doi:10.1039/c4fo00013g

Cited by 9 publications

(6 citation statements)

References 68 publications

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“…24 The rats in the normal control group were treated with the same volume of citrate buffer. 24 The rats in the normal control group were treated with the same volume of citrate buffer.…”

Section: Diabetes Induction and Experimental Designmentioning

confidence: 99%

“…After the rats were subjected to an overnight fasting, the rats were intraperitoneally injected with 60 mg per kg bw STZ (Sigma Chemicals, St. Louis, MO, USA) dissolved in 0.1 mol L −1 of citrate buffer ( pH 4.5). 24 The rats in the normal control group were treated with the same volume of citrate buffer. Three days after STZ was injected, the fasting blood glucose (FBG) of the rats was measured from the tail tip.…”

Section: Diabetes Induction and Experimental Designmentioning

confidence: 99%

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Hypoglycemic effects of Zanthoxylum alkylamides by enhancing glucose metabolism and ameliorating pancreatic dysfunction in streptozotocin-induced diabetic rats

et al. 2015

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This study aimed to evaluate the hypoglycemic effect of Zanthoxylum alkylamides and explore the potential mechanism in streptozotocin (STZ)-induced diabetic rats. Diabetic rats were orally treated with 3, 6, and 9 mg per kg bw alkylamides daily for 28 days. As the alkylamide dose increased, the relative weights of the liver and kidney, fasting blood glucose, and fructosamine levels were significantly decreased. The alkylamides also significantly increased the body weight and improved the oral glucose tolerance of the rats. Likewise, the alkylamides significantly increased the levels of liver and muscle glycogen and plasma insulin. These substances further alleviated the histopathological changes in the pancreas of the diabetic rats. The beneficial effects of high-dose alkylamides showed a comparable activity to the anti-diabetic drug glibenclamide. Western blot and real-time PCR results revealed that the alkylamide treatment significantly decreased the expression levels of the key enzymes (phosphoenolpyruvate caboxykinase and glucose-6-phosphatase) involved in gluconeogenesis and increased the glycolysis enzyme (glucokinase) in the liver, and enhanced the expression levels of pancreatic duodenal homeobox-1, glucokinase, and glucose transporter 2 in the pancreas. In addition, it was also observed that the alkylamides, unlike glibenclamide, increased the transient receptor potential cation channel subfamily V member 1 and decreased cannabinoid receptor 1 expressions in the liver and pancreas. Therefore, alkylamides can prevent STZ-induced hyperglycemia by altering the expression levels of the genes related to glucose metabolism and by ameliorating pancreatic dysfunction.

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“…24 The rats in the normal control group were treated with the same volume of citrate buffer. 24 The rats in the normal control group were treated with the same volume of citrate buffer.…”

Section: Diabetes Induction and Experimental Designmentioning

confidence: 99%

Section: Diabetes Induction and Experimental Designmentioning

confidence: 99%

Hypoglycemic effects of Zanthoxylum alkylamides by enhancing glucose metabolism and ameliorating pancreatic dysfunction in streptozotocin-induced diabetic rats

et al. 2015

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“…Diabetes is a metabolic disorder associated with abnormalities in insulin production or secretion along with modifications in carbohydrate, fat and protein metabolism [96,97]. In accordance to, Riya et al, determined the presence of betulin, alpha amyrin and beta sitosterol in flower, leaf and roots of Aerva lanata [7,98].…”

Section: Anti-diabeticmentioning

confidence: 99%

“…In accordance to, Riya et al, determined the presence of betulin, alpha amyrin and beta sitosterol in flower, leaf and roots of Aerva lanata [7,98]. However, there are reports that betulin is useful in treatment of diabetes [99,100]. As 70% ethanolic extract (ALE) for 21 days in STZ-induced diabetic rat demonstrated that ALE was successful in refining postprandial hyperglycemia in sucrose-loaded normal and STZ diabetic rats, through its promising alpha glucosidase inhibitory potential [101,102].…”

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confidence: 96%

Betulin, a Pentacyclic Tri-Terpenoid: An Hour to Rethink the Compound

Singh¹

2017

OAJTMR

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Betulin, a pentacyclic triterpenoid member of lupane family occurs widely in numerous plants. Betulin, unlike most other constituents is easily isolated that it can be utilized for various pharmacological actions. It is interesting to know that betulin can be easily extracted from bark, stem, leaves, flower, roots etc. of the plant. This review summarizes plethora of reliable pharmacological activities like antiinflammatory, anti-ulcer, anti-diabetic, anti-bacterial, anti-microbial, anti-malarial, anti-viral, anti hyperlipidaemic, anti-cancer and anti HIV exhibited by betulin and its derivatives. For this it can be utilized in herbal as well as synthetic pharmaceutical industries because of its promising efficacy and low levels of toxicity. Although betulin possess a wide range of pharmacological activities, there is still lack of awareness of its proper utilization in the field of medicine. So, need of the hour is to refocus on naturally occurring betulin and its derivatives to avoid side effects caused by synthetic compounds utilized in treating various ailments. Therefore, the aim of the present review is to re-explore the potential of betulin, as an alternative to the compounds possessing higher side effects. Keywords: Table1:Represents the physical properties of betulin [1,30,31] Occurrence of Betulin in NatureBetulin has long been explored by research scientist because of the fact that it has anticancer properties [35,36] and its derivative Betulinic acid is favored due to its anti-HIV activity [12,6,37]. As mentioned in Figure 1: betulin has three most prominent positions where chemical modifications can be easily accomplished, namely primary hydroxyl group at position C-28, secondary hydroxyl group at position C-3, and alkene moiety at position C-20.The bio-chemical modifications at positions C-28 of the parent structure of betulin produces betulinic acid [12,27,[38][39][40][41]. The chief source of Betulin is bark of Birch trees, belonging to family Betulaceae the family of flowering plants. Mostly placed in order Fagales, it can also be placed in order Betulales. The subfamilies include Betuloideae genera Betula (birch), Alnus (alder) and Coryloideaegenera Carpinus (hornbeam), Corylus (hazel), Ostrya and Ostryopsis [42][43][44]. Betulin, a pentacyclictriterpenoid is derived from linear hydrocarbon squalene [31]. Triterpenes have three main classes oleane, ursane and lupane triterpenes. Lupane class comprises betulin, betulinic acid, lupeol [6,45]. Triterpenes are used as traditional herbal medicine and the esters of betulin and fatty acids are used in the production of cosmetics and as plasticizers for PVC [31,46] (Table 2). Pharmacological StudiesBetulin, as we all known till now possess vast pharmacological properties including choleritic, antihelmintic, powerful prophylactic, anti-HIV, antimutagene agent, antiviral, antifungal, anti-leukemia, anti-leishmanial, anti-inflammatory, immunomodulator activities. The latest research suggests some of the major pharmacological properties as discu...

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“…(AL; common name: polpala or mountain knotgrass) is a popular plant used in folk medicine. Due to its use in traditional medicine in the treatment of diabetes, arthritis, and urinary system diseases, the plant is of great interest to the pharmaceutical and nutraceutical industries [4]. A. lanata (L.) Juss.…”

Section: Introductionmentioning

confidence: 99%

LC-ESI-MS/MS Polyphenolic Profile and In Vitro Study of Cosmetic Potential of Aerva lanata (L.) Juss. Herb Extracts

et al. 2022

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The aim of the present study was to investigate the phenolic composition and the biological properties of different Aerva lanata (L). Juss. herb extracts obtained with the use of accelerated solvent extraction (ASE), i.e., a green, ecological method, for cosmetic purposes. All samples exhibited high DPPH• (9.17–119.85 mg TE/g) and ABTS•+ (9.90–107.58 mg TE/g) scavenging activity. The extracts exhibited considerable anti-lipoxygenase (EC50 between 1.14 mg/mL and 3.73 mg/mL) and anti-xanthine oxidase (EC50 between 1.28 mg/mL and 3.72 mg/mL) activities, moderate chelating activity (EC50 between 1.58 mg/mL and 5.30 mg/mL), and high antioxidant potential in the ORAC assay (0.36–3.84 mM TE/g). Changes in the polyphenol profile of the analysed samples depending on the solvent and temperature used for the extraction were determined with the liquid chromatography/electrospray mass spectrometry (LC-ESI-MS/MS) method. Twenty-one phenolic compounds, including flavonoids and phenolic acids, were detected and quantified. It was shown that tiliroside was one of the main phenolic metabolites in the A. lanata (L.) Juss. herb., which may suggest that this compound may be largely responsible for the observed anti-inflammatory activity of the extracts. In addition, the studied extracts exhibited promising skin-related (anti-tyrosinase, anti-elastase, anti-collagenase, and anti-hyaluronidase) activity. This study showed that Aerva lanata (L.) Juss. contains high amounts of phenolic compounds, including tiliroside, and has good skin-related activities. Therefore, the plant may be interesting as a novel source of bioactive agents for cosmetic industries.

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Nutraceutical potential of Aerva lanata (L.) Juss. ex Schult ameliorates secondary complications in streptozotocin-induced diabetic rats

Cited by 9 publications

References 68 publications

Hypoglycemic effects of Zanthoxylum alkylamides by enhancing glucose metabolism and ameliorating pancreatic dysfunction in streptozotocin-induced diabetic rats

Hypoglycemic effects of Zanthoxylum alkylamides by enhancing glucose metabolism and ameliorating pancreatic dysfunction in streptozotocin-induced diabetic rats

Betulin, a Pentacyclic Tri-Terpenoid: An Hour to Rethink the Compound

LC-ESI-MS/MS Polyphenolic Profile and In Vitro Study of Cosmetic Potential of Aerva lanata (L.) Juss. Herb Extracts

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