Nutmeg poisoning: Ten years (2008–2018) of experience from the Marseille Poison Control Center

Reynoard, Julien; Torrents, Romain; Domangé, B.; Glaizal, Mathieu; Haro, Luc de; Simon, Nicolas

doi:10.1016/j.lpm.2019.08.016

Cited by 9 publications

(3 citation statements)

References 11 publications

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“…Several cases of intoxication have been reported after a 5 g nutmeg ingestion which corresponds to 1-2 mg of myristicin per kilogram body weight [ 11 ]. Another study demonstrated intoxication of all participants (n=22) after ingestion of 10 g of nutmeg powder which is equivalent to approximately two teaspoons of powdered nutmeg or three-fourths tablespoon of grated nutmeg [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

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Nutmeg Intoxication: A Case Report

Casale,

MacDonald,

Mitra

2023

Cureus

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Nutmeg intoxication is an uncommon precipitant of hyperactive delirium with severe agitation (HDSA) with anticholinergic properties that require a high index of suspicion for diagnosis. We present a case of a young adult who presented to the emergency department (ED) with HDSA. The patient was intubated and transferred to the medical intensive care unit (MICU) due to increasing safety threats unresponsive to multimodal de-escalation. He ultimately self-extubated, reported excessive nutmeg ingestion, and was discharged home after a short period of observation. Improved detection and streamlined management pathways for nutmeg intoxication will minimize unnecessary invasive procedures and costs to the healthcare system.

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Section: Discussionmentioning

confidence: 99%

“…Benzodiazepines are particularly effective for anxiety and agitation associated with nutmeg intoxication [ 15 ]. There is also a possible benefit of activated charcoal in patients with intact airways [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Nutmeg Intoxication: A Case Report

Casale,

MacDonald,

Mitra

2023

Cureus

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“…A retrospective study on human exposure to toxic substances between 2008 and 2018 covering the French Mediterranean coast identified 31 cases of nutmeg intoxication, nine of which were excluded due to insufficient data (Reynoard et al, 2019). Clinical effects included neuropsychiatric disorders (hallucinations, blurred vision, and agitation), gastrointestinal disorders (abdominal pain and diarrhea), sore throat, dry mouth, feeling faint, and tachycardia.…”

Section: Myristica Fragrans Houtt Contraindicationsmentioning

confidence: 99%

Myristicin: From its biological effects in traditional medicine in plants to preclinical studies and use as ecological remedy in plant protection

Ramírez‐Alarcón

Martorell

Gürer

et al. 2023

eFood

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Myristicin is an allylbenzene and a major key constituent of many plant species, such as Myristica fragrans Houtt. (nutmeg), Foeniculum vulgare Mill. (fennel), and Petroselinum crispum (Mill.) Fuss (parsley). Their plant parts have been used in traditional medicine and as a flavoring seasoning for cooking but, and as biopesticides with natural compounds. Myristicin has been related with several biological effects, such as anticarcinogenic, anti‐inflammatory, antimicrobial, antioxidant, antidiabetic, analgesic, and hepatoprotective. The traditional uses include the treatment of complications related to gastrointestinal tract, respiratory system, and gynecological disorders. However, several studies have been reported contraindications associated to high dose consumption of myristicin. This review summarizes the biological activities of myristicin and myristicin‐rich plants, toxicological effects along with its bioavailability, and metabolism. In addition, their traditional uses and their role as ecological remedy in plants protection has been reviewed. Nutmeg is the myristicin‐rich plant with more pharmacological effects reported but also with most contraindication and toxically reports.

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Different therapies of Chinese herbal medicine for diarrhea-predominant irritable bowel syndrome: A network meta-analysis of double-blinded, placebo-controlled trials

Liu

Wang

et al. 2023

Journal of Ethnopharmacology

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Nutmeg poisoning: Ten years (2008–2018) of experience from the Marseille Poison Control Center

Cited by 9 publications

References 11 publications

Nutmeg Intoxication: A Case Report

Nutmeg Intoxication: A Case Report

Myristicin: From its biological effects in traditional medicine in plants to preclinical studies and use as ecological remedy in plant protection

Different therapies of Chinese herbal medicine for diarrhea-predominant irritable bowel syndrome: A network meta-analysis of double-blinded, placebo-controlled trials

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